Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum

Fukuda, Mamoru; Peppas, Nicholas A.; McGinity, James W.

doi:10.1016/j.ijpharm.2005.11.042

Cited by 120 publications

(42 citation statements)

References 44 publications

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“…In another study, these researchers also investigated the influence of pH, buffer species, and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process (Fukuda et al, 2006b). Drug release from hot-melt extruded tablets containing either chitosan or xanthan gum was pH and buffer species dependent.…”

Section: Tablets and Capsulesmentioning

confidence: 99%

Pharmaceutical Applications of Hot-Melt Extrusion: Part II

Repka

Battu

Upadhye

et al. 2007

Drug Development and Industrial Pharmacy

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320

158

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The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.

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Section: Tablets and Capsulesmentioning

confidence: 99%

Pharmaceutical Applications of Hot-Melt Extrusion: Part II

Repka

Battu

Upadhye

et al. 2007

Drug Development and Industrial Pharmacy

Self Cite

320

158

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“…The mannose to galactose ratio is usually 4:1, and the galactose units are unequally distributed along the mannose backbone, depending on the nature of its origin and the methods of its extraction (Dea et al [9]). Both of these polymers have already been used in the development of modifiedrelease matrix tablets (Talukdar et al [10]; Fukuda et al [11]; Coviello et al [12]). …”

Section: Fig 1 Molecular Structure Of Xanthanmentioning

confidence: 99%

The reflection of the texture of swollen polymer matrix on the release of incorporated substance

Pavli

Kristl²,

Dolenc³

et al. 2009

E-Polymers

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Abstract:Our aim was to investigate the texture of hydrated biopolymer matrices that are now being considered in the design of pharmaceutical controlled-release dosage forms, in order to determine their influence on the release of an active compound. Prolonged release of pentoxifylline, a highly soluble drug, is needed for once-daily administration to achieve its therapeutic effect. For this purpose, pentoxifylline was incorporated in a polymer matrix made of a combination of xanthan and locust bean gum (XLBG), both of which are of biotechnological origin. Different methods were used to investigate the interplay of the XLBG gel structure characteristics in the absence and presence of 200 mM CaCl 2 on pentoxifylline release: drug-release studies, determination of swelling, erosion, and viscoelasticity of the gel, as well as its texture analysis and microscopic imaging. From the results obtained, the following conclusions can be drawn: the pentoxifylline release from XLBG matrices in water was prolonged for 24 h whereas from the control lactose formulation was completed within 30 min. The presence of Ca 2+ ions in water resulted in faster pentoxifylline release, in spite of less swelling and erosion. However, the rheology, texture analysis and scanning electron microscopy revealed that in the presence of the Ca 2+ ions the gel layer of the XLBG was more cohesive and thinner, as the attraction for water molecules was lower due to the condensation of counter-ions on the xanthan carboxylic-moieties, and consequently greater interpolymer interactions. Therefore, relatively larger amounts of free water molecules were available within the XLBG hydrogel in the presence of Ca 2+ , allowing faster drug dissolution and diffusion. Here, the presence of Ca 2+ ions had a completely opposite effect on XLBG gel structure and drug release in comparison with other more investigated matrix polymers like alginate or non-ionic cellulose ethers. A firm matrix structure that is accompanied by low swelling and erosion cannot guarantee a more prolonged drug release.

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“…Ideal controlled release dosage forms are such that provide/maintain therapeutic drug concentration throughout dosing interval [1]. To obtain maximum efficacy and minimum side effects it is necessary to deliver the drugs to target site in optimal amount and for required time period [2].…”

Section: Introductionmentioning

confidence: 99%