Prophylactic and Therapeutic Effects of Curcumin on Treatment-Induced Oral Mucositis in Patients with Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials

Zhang, Linyu; Tang, Gang; Wei, Zhengqiang

doi:10.1080/01635581.2020.1776884

Cited by 21 publications

(19 citation statements)

References 27 publications

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“…Relevant evidence exhibited that Cur can effectively prevent and treat oral diseases, such as oral mucositis (OM) (GRADE level: low) and chronic periodontitis (GRADE level: moderate) (Dharman et al, 2021; Guo et al, 2021; Souza et al, 2021; Terby et al, 2021; Yuan, 2019; Zhang, Tang, & Wei, 2021). However, the results of several studies failed to show a positive effect of oral disease (GRADE level: low) (Al‐Maweri et al, 2021; Oliveira et al, 2021; Zhang, Huang, et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…The surgery is any type of surgery, including laparoscopic surgery, gynecological surgery and mixed surgery. Moreover, Cur consumption has beneficial associations with neurodegenerative diseases, depression, gastrointestinal diseases, and oral diseases (Chandan et al, 2020;Wang, Zhang, et al, 2021;Zhang, Tang, & Wei, 2021). (Kao & Huang, 2021).…”

Section: The Conclusion Of the Beneficial Relationship Betweenmentioning

confidence: 99%

“…As one of the key ingredients, Cur has been reported to have anti‐inflammatory, anti‐oxidant, anti‐cancer, and anti‐bacterial activities and other pharmacological functions (Hosseini‐Zare, Sarhadi, Zarei, Thilagavathi, & Selvam, 2021). Recent epidemiological studies on the health effects of Zingiberaceae plants/Cur supplementation have been expanded to include metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), pain relief, nausea and vomiting, gastrointestinal diseases, neuroprotection, and other outcomes (Asbaghi et al, 2020; Ashtary‐Larky et al, 2021; Baziar & Parohan, 2020; Chandan et al, 2020; Tabrizi et al, 2018; Wang et al, 2021; Wang, Zhang, Huang, & Liu, 2021; Zhang, Tang, & Wei, 2021; Zhu, Dai, Huang, & Li, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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This umbrella review is to recapitulate and grade the available evidence of associations between consumption of Zingiberaceae plants/curcumin (Cur) and multiple health‐related outcomes. This study included 161 meta‐analyses of randomized controlled trials in 76 articles with 67 unique health outcomes. Data on heterogeneity and publication bias are considered to assess the quality of evidence. Based on the different impact of Zingiberaceae plants/Cur on human health, the advantages outweigh the disadvantages. Zingiberaceae plants/Cur can mainly improve metabolic syndrome, non‐alcoholic fatty liver disease, cardiovascular disease, and some chronic inflammatory diseases, likewise, obviously relief the pain of osteoarthritis and related diseases. Ginger supplements have been shown to improve vomiting during pregnancy and to relieve nausea and vomiting caused by chemotherapy and surgery. The surgery is any type of surgery, including laparoscopic surgery, gynecological surgery and mixed surgery. Beneficial associations were found with Cur intervention in gastrointestinal, neurological and oral diseases. Zingiberaceae plants/Cur are generally safe and favorable for multiple health outcomes in humans. High‐quality research is further needed to prove the observed associations.

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Section: Resultsmentioning

confidence: 99%

Section: The Conclusion Of the Beneficial Relationship Betweenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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“…Based on the aforementioned effects, curcumin may play a role as an antineoplastic compound, inhibiting tumor cell proliferation and suppressing chemically induced carcinogenesis or tumor growth in HNSCC animal models [ 127 , 128 ]. Furthermore, and as with the rest of the previously reviewed compounds, a recent meta-analysis shows the beneficial effects of curcumin both in the prevention and in the treatment of radiotherapy-induced mucositis [ 130 ]. Moreover, a possible topical application for the prevention of oral carcinoma has been theorized on the basis that it would inhibit the inflammatory factors chemokine ligand 1 (CXCL1) and tumor necrosis factor alpha (TNF-α) [ 131 ].…”

Section: Other Antioxidants With Potential Epigenetic Effect On Squamous Cell Carcinoma Of the Head And Neckmentioning

confidence: 99%

Usefulness of Melatonin and Other Compounds as Antioxidants and Epidrugs in the Treatment of Head and Neck Cancer

Guerra¹,

Devesa²

2021

Antioxidants

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Along with genetic mutations, aberrant epigenetic alterations are the initiators of head and neck cancer carcinogenesis. Currently, several drugs are being developed to correct these epigenetic alterations, known as epidrugs. Some compounds with an antioxidant effect have been shown to be effective in preventing these malignant lesions and in minimizing the complications derived from cytotoxic treatment. Furthermore, in vitro and in vivo studies show a promising role in the treatment of head and neck squamous cell carcinoma (HNSCC). This is the case of supplements with DNA methylation inhibitory function (DNMTi), such as epigallocatechin gallate, sulforaphane, and folic acid; histone deacetylase inhibitors (HDACi), such as sodium butyrate and melatonin or histone acetyltransferase inhibitors (HATi), such as curcumin. The objective of this review is to describe the role of some antioxidants and their epigenetic mechanism of action, with special emphasis on melatonin and butyric acid given their organic production, in the prevention and treatment of HNSCC.

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“…claimed that curcumin could be safe and preventive about treatment-induced OM in patients with HNCs. It can also reduce OM-induced weight loss (L. Zhang, Tang, & Wei, 2020). Moreover, in a network meta-analysis of 28 RCTs, the effects of nine oral care solutions on preventing OM in cancer patients undergoing radiotherapy and chemotherapy were evaluated.…”

Section: Curcuminmentioning

confidence: 99%

The effects of herbal medicines on cancer therapy‐induced oral mucositis: A literature review

Safarzadeh

Shirban

Bagherniya

et al. 2021

Phytotherapy Research

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Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free radicals can act as a trigger for an inflammatory milieu that causes OM. Based on the debilitating nature of OM, finding a safe and inexpensive agent with anti-inflammatory, anti-microbial, and antioxidative properties can be valuable for this situation.Considering the harmful effects of some chemical agents, herbal medicine has been suggested as a potential alternative owing to unique properties such as safety, availability and low cost. Many studies have illustrated several pharmacological properties of herbal medicines in recent years, such as anti-inflammatory, anti-microbial, and antioxidative activities, which are essential factors in the palliation of cancer therapyinduced OM. This review aimed to evaluate herbal medicines' effects on cancer therapy-induced OM. According to this comprehensive review, it is concluded that medicinal plants and phytochemicals can be used as practical agents in the palliation of cancer therapy-induced OM without any serious side effects.

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Prophylactic and Therapeutic Effects of Curcumin on Treatment-Induced Oral Mucositis in Patients with Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials

Cited by 21 publications

References 27 publications

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Usefulness of Melatonin and Other Compounds as Antioxidants and Epidrugs in the Treatment of Head and Neck Cancer

The effects of herbal medicines on cancer therapy‐induced oral mucositis: A literature review

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