Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease

Pannu, Naveet; Bhatnagar, Archana

doi:10.1007/s10787-020-00717-3

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…[17,43] Also, the ability of resveratrol to reduce oxidative stress is observed in murine models of lupus-like disease. [44] These protective effects may be attributed to antioxidant ability, where resveratrol, as a polyphenol compound, is capable of scavenging free radicals through its benzene-bound hydroxyl groups and enhancement of antioxidant enzyme activities in different organs. [17,45] Therefore, we can assume that resveratrol can protect against diclofenac-induced hepatorenal damage via an antioxidant effect.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis

Elbaz

Ahmed

Abdelmonem

2022

J Biochem & Molecular Tox

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Despite the extensive therapeutic uses of diclofenac, it may cause several adverse effects, including hepatorenal injury. The antioxidant and anti-inflammatory properties of resveratrol, a polyphenolic compound, make the agent effective in ameliorating a variety of drug-induced injuries. This study investigated the potential beneficial effects of resveratrol on diclofenac-induced hepatorenal toxicity and explored the role of miR-144 and its relationship to oxidative stress and inflammation triggered by diclofenac. Rats were divided into four groups: control; diclofenac group received diclofenac (10 mg/kg/day, intraperitoneal [ip]) for 7 days; prevention group received resveratrol concomitantly with diclofenac for 7 days; and the treatment group received diclofenac for 7 days followed by resveratrol (20 mg/kg/day, per oral) for another 7 days. Diclofenac administration induced a significant increase in serum hepatorenal biomarkers and histopathological aberrations. In addition, diclofenac upregulated miR-144 while reducing nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and glutathione (GSH) content.Moreover, diclofenac induced tissue inflammation and apoptosis as evidenced by increased protein expression of nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), and caspase-3. Intriguingly, resveratrol prevention or treatment significantly mitigated the toxic effects of diclofenac as manifested by normalization of the hepatorenal functions and amelioration of the histopathological changes.Resveratrol also triggered miR-144 downregulation with Nrf2 upregulation.Consequently, resveratrol showed hepatorenal antioxidant, anti-inflammatory, and antiapoptotic activities as manifested by improvement in the antioxidant markers along with a decline in NF-κB, TNF-α, and caspase-3 expressions. In conclusion, this study demonstrates a potential therapeutic role of resveratrol in mitigating diclofenac-induced hepatorenal insult, possibly via modulating miR-144/Nrf2/ GSH axis.

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Section: Discussionmentioning

confidence: 99%

Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis

Elbaz

Ahmed

Abdelmonem

2022

J Biochem & Molecular Tox

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“…Pannu and Bhatnagar further examined whether prophylactic treatment with resveratrol and piperine can prevent lupus-like manifestations in the BALB/c mice ( Pannu and Bhatnagar, 2020b ).…”

Section: Results and Context Of Included Studiesmentioning

confidence: 99%

“…They found that prophylactic resveratrol and prophylactic piperine were equally efficient in mitigating oxidative stress (enzyme activity of catalase, superoxide dismutase, glutathione peroxidase, and level of reduced glutathione, lipid peroxidation, and reactive oxygen species) ( Pannu and Bhatnagar, 2020b ). These compounds reduced levels of IL-6 and TNF-α, and piperine administered alone significantly reduced urine creatinine level and proteinuria ( Pannu and Bhatnagar, 2020b ). Additionally, piperine prophylactic treatment enhanced liver and lung histopathology and decreased pulmonary immune complexes ( Pannu and Bhatnagar, 2020b ).…”

Section: Results and Context Of Included Studiesmentioning

confidence: 99%

“…These compounds reduced levels of IL-6 and TNF-α, and piperine administered alone significantly reduced urine creatinine level and proteinuria ( Pannu and Bhatnagar, 2020b ). Additionally, piperine prophylactic treatment enhanced liver and lung histopathology and decreased pulmonary immune complexes ( Pannu and Bhatnagar, 2020b ). The study reports that resveratrol decreased the susceptibility of developing a lupus-like disease in the mice, and its effect was not enhanced by piperine ( Pannu and Bhatnagar, 2020b ).…”

Section: Results and Context Of Included Studiesmentioning

confidence: 99%

“…Additionally, piperine prophylactic treatment enhanced liver and lung histopathology and decreased pulmonary immune complexes ( Pannu and Bhatnagar, 2020b ). The study reports that resveratrol decreased the susceptibility of developing a lupus-like disease in the mice, and its effect was not enhanced by piperine ( Pannu and Bhatnagar, 2020b ). These findings have potential applications in the treatment of CLE as the effect of Resveratrol mimics the inhibition of proinflammatory cytokines such as TNF-α and IFN-α seen in the antimalarials that are currently used in treating SLE and CLE ( Alves et al, 2017 ).…”

Section: Results and Context Of Included Studiesmentioning

confidence: 99%

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Medicinal Plant Extracts and Natural Compounds for the Treatment of Cutaneous Lupus Erythematosus: A Systematic Review

et al. 2022

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Cutaneous lupus erythematosus (CLE) is a group of autoimmune connective tissue disorders that significantly impact quality of life. Current treatment approaches typically use antimalarial medications, though patients may become recalcitrant. Other treatment options include general immunosuppressants, highlighting the need for more and more targeted treatment options. The purpose of this systematic review was to identify potential compounds that could be repurposed for CLE from natural products since many rheumatologic drugs are derived from natural products, including antimalarials. This study was registered with PROSPERO, the international prospective register of systematic reviews (registration number CRD42021251048). We comprehensively searched Ovid Medline, Cochrane Library, and Scopus databases from inception to April 27th, 2021. These terms included cutaneous lupus erythematosus; general plant, fungus, bacteria terminology; selected plants and plant-derived products; selected antimalarials; and JAK inhibitors. Our search yielded 13,970 studies, of which 1,362 were duplicates. We screened 12,608 abstracts, found 12,043 to be irrelevant, and assessed 565 full-text studies for eligibility. Of these, 506 were excluded, and 59 studies were included in the data extraction. The ROBINS-I risk of bias assessment tool was used to assess studies that met our inclusion criteria. According to our findings, several natural compounds do reduce inflammation in lupus and other autoimmune skin diseases in studies using in vitro methods, mouse models, and clinical observational studies, along with a few randomized clinical trials. Our study has cataloged evidence in support of potential natural compounds and plant extracts that could serve as novel sources of active ingredients for the treatment of CLE. It is imperative that further studies in mice and humans are conducted to validate these findings.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251048.

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SIRT1 slows the progression of lupus nephritis by regulating the NLRP3 inflammasome through ROS/TRPM2/Ca2+ channel

Tian,

Huang,

Chen

et al. 2023

Clin Exp Med

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Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease

Cited by 5 publications

References 23 publications

Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis

Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis

Medicinal Plant Extracts and Natural Compounds for the Treatment of Cutaneous Lupus Erythematosus: A Systematic Review

SIRT1 slows the progression of lupus nephritis by regulating the NLRP3 inflammasome through ROS/TRPM2/Ca2+ channel

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