Prophylactic use of antibiotics as per SIGN 104 guidelines versus routine antibiotic prophylaxis for prevention of surgical site infection in clean and clean contaminated ENT surgical procedures: a comparative study

Bharath, MM Srinivas; Galagali, J. R.; Mishra, Awadhesh Kumar; Mallick, Ajay; Nikhilesh, E.

doi:10.18203/issn.2454-5929.ijohns20195698

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…2 However, it has been noted that prolonged antibiotic prophylaxis does not decrease surgical infection and is associated with higher levels of bacterial resistance. 3 Although, we have effective guidelines proposed for prophylaxis and treatment of SSIs, a constant threat by emerging MDR organisms is alarming. Evidence showed that MRSA and MR-CNS strains isolated from surgical wounds showed multi-drug resistance towards ampicillin, cotrimoxazole, erythromycin, clindamycin, ciprofloxacin, cefotaxime and ceftazidime.…”

Section: Introductionmentioning

confidence: 99%

Antibiotics in Prevention and Treatment of Multi-Drug Resistant (MDR) Organisms causing Surgical Site Infection (SSI)

Lakshmi

Gowda

Anuradha

2020

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Antibiotics play a vital role in prevention and treatment of various infections. But inappropriate antibiotic choice could lead to emergence of multi-drug resistance (MDR) among microorganisms. Since, the antibiotic susceptibility pattern of organisms could vary from place to place; forming a local prophylaxis and treatment protocol could hugely reduce this global burden. The primary objectives of the study were to observe the frequency of multi-drug resistant organisms causing Surgical Site Infections (SSIs) and to study the pattern of antibiotic usage for the prophylaxis and treatment of SSIs. A descriptive study was carried out in general surgical wards of KR hospital, Mysore for a period of 18 months (2015-2016). The relevant data was collected from the case sheets of patients who were diagnosed with SSI. Pus samples were collected, and culture-sensitivity was done. Collected data were analyzed using relevant statistical tests. A total of 263 study subjects including both males and females were enrolled in the study. Cefotaxime was the most common antibiotic used for pre-surgical prophylaxis (n=221). Out of 263 pus samples 92% were culture positive. The most common organisms causing SSI were E-coli-ESBL (n=73) and MRSA (n=44). About 95% of organisms showed multi-drug resistance. Imipenem, Gentamicin, Piperacillin-Tazobactum and Linezolid were the most common antibiotics used in the treatment of SSIs. The result of the study is alarming. Overall, there is great rise in the prevalence of MDR organisms causing SSIs. The hospital antibiotic policy should be revised in such a way to decrease the emergence of MDR microbes.

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Section: Introductionmentioning

confidence: 99%

Antibiotics in Prevention and Treatment of Multi-Drug Resistant (MDR) Organisms causing Surgical Site Infection (SSI)

Lakshmi

Gowda

Anuradha

2020

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Analysis of the use of antibiotics profile and factors of surgical site infections study on digestive and oncology surgeries

Narulita

Suharjono

Kuntaman

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives The incision method operation with a high risk of infection in a clean and clean-contaminated operation requires the use of prophylactic antibiotics to minimize the risk of infection. This study was designed to analyze the effectiveness of prophylactic antibiotics in patients with digestive and oncology surgeries. Methods The statistical method used was chi-square to determine the risk factors for infection at surgical site infections (SSI) in patients with digestive and oncology surgeries. This study had received ethical approval from the Ethics Committee of Dr. H. Slamet Martodirdjo Hospital, Pamekasan. Results There were 67 patients consisted of 48 digestive surgeries (71.6%) and 19 oncology surgeries (28.4%). The criteria of observation on day 30 showed that as 1 (1.5%) SSI patient experienced purulence, inflammation, and erythema around the surgical wound so an analysis of p>0.05 was carried out so that there was no association with the incidence of SSI during hospitalization, but other factors originating from the patient, such as a lack of personal hygiene at home and lack of nutritious food intake was measured in temperature, pulse, respiration, and white blood cells examination before surgery and 24 h after surgery, all within normal ranges. The qualitative analysis of prophylactic antibiotics using the Gyssen method showed that 31 (46.3%) rationales needed an improvement process. Conclusions The widely used prophylactic antibiotics, namely cefazolin and cefuroxime are recommended antibiotics used in incision surgery and rationale used.

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Prophylactic use of antibiotics as per SIGN 104 guidelines versus routine antibiotic prophylaxis for prevention of surgical site infection in clean and clean contaminated ENT surgical procedures: a comparative study

Cited by 2 publications

References 19 publications

Antibiotics in Prevention and Treatment of Multi-Drug Resistant (MDR) Organisms causing Surgical Site Infection (SSI)

Antibiotics in Prevention and Treatment of Multi-Drug Resistant (MDR) Organisms causing Surgical Site Infection (SSI)

Analysis of the use of antibiotics profile and factors of surgical site infections study on digestive and oncology surgeries

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