Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments

Klockgether-Radke, A.; Frerichs, A.; Kettler, D.; Hellige, G.

doi:10.1097/00003643-200008000-00004

Cited by 13 publications

(5 citation statements)

References 39 publications

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“…28,29 The vascular distensibility of the muscular vessels is affected by sympathetic nerve activity. It is very likely that the influence of anesthesia, whereby the vascular smooth muscle of the muscular vessels relaxes and expands, is reflected in baPWV, as ABPI decreased uniformly despite being measured at 10 min after tracheal intubation under general anesthesia (that is, ankle SBP decreased to a greater degree than brachial SBP).…”

Section: Discussionmentioning

confidence: 99%

Influence of blood pressure on cardio-ankle vascular index (CAVI) examined based on percentage change during general anesthesia

et al. 2011

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Cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) are non-invasive methods for estimating arterial distensibility. The purpose of this study is to evaluate whether CAVI as an index of true arterial stiffness is superior to baPWV based on the percentage change in hemodynamics under general anesthesia. CAVI (segment from heart to ankle), k-CAVI (heart to knee) and baPWV (brachial to ankle) in 30 oral surgery patients were measured to compare the decreased blood pressure (BP) after 10 min of tracheal intubation during general anesthesia with the control BP (after 5 min of rest). General anesthesia was performed under endotracheal intubation through intravenous injection of propofol, fentanyl and vecuronium or rocuronium. In both the elderly (X65 years) and middle-aged (o65 years) groups, CAVI and k-CAVI did not change during general anesthesia, whereas baPWV and systolic BP (SBP) showed a statistically significant decrease. Thus, the changes in CAVI (DCAVI) and k-CAVI (Dk-CAVI) showed no significant correlations with those of SBP (DSBP), whereas the changes in baPWV (DbaPWV) were significantly correlated with DSBP. DCAVI and Dk-CAVI showed no significant differences between the two groups, whereas DbaPWV and DSBP in the elderly group was much higher than that in the middle-aged group. Measurement of CAVI was not affected by the decrease in BP during general anesthesia. In contrast, baPWV was significantly influenced by changes in BP. These findings suggest that CAVI is a useful index of true arterial stiffness and is superior to baPWV.

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Section: Discussionmentioning

confidence: 99%

Influence of blood pressure on cardio-ankle vascular index (CAVI) examined based on percentage change during general anesthesia

et al. 2011

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“…It is possible to affirm that the changes in PaCO 2 were related to gas exchange that was impaired by serotonin-induced vasoconstriction (Hashimoto et al, 2000) and bronchoconstriction (Hashimoto et al, 2000;Hirota et al, 2002). Thus, the dose of thiopental used may have attenuated the serotonin-induced pulmonary vasoconstriction (Gross e Abel 1985, Klockgether-Radke et al 2000 and bronchoconstriction (Okamura and Denorough, 1980;Gross and Abel, 1985) promoted lower PaCO 2 when compared with propofol.…”

Section: Resultsmentioning

confidence: 97%

“…Gross and Abel (1985) found that less than 3 x 10 -4 M thiopental concentration-dependently potentiated serotonin-induced contraction of the rabbit basilar artery, whereas more than 3 x 10 -4 M thiopental dose-dependently relaxed it. In a study with three vasoconstrictors (serotonin, histamine and acetylcholine), Klockgether-Radke et al (2000) concluded that this thiobarbiturate relaxes isolated coronary segments in a dose-dependent manner, and there was no evidence that these effects were dependent on endothelial factors. Thus, considering the animal preparation and times of measurement, the high concentration of this drug may have attenuated the serotonin-induced pulmonary vasoconstriction.…”

Section: Resultsmentioning

confidence: 99%

Cardiopulmonary parameters in propofol- or thiopental-anesthetized dogs induced to pulmonary hypertension by serotonin

Lopes¹,

Nunes²,

Paula³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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Cardiopulmonary parameters in propofol-or thiopental-anesthetized dogs induced to pulmonary hypertension by serotonin ABSTRACTThe cardiopulmonary changes in propofol-or thiopental-anesthetized dogs induced to pulmonary hypertension (PH) were evaluated. Twenty adult animals were randomly assigned to two groups: propofol group (PG) and thiopental group (TG). In PG, propofol was used for induction (80.03mg.kg -1 ) and anesthesia maintenance (0.8mg.kg -1 .minute -1 ), while, in TG, thiopental was used (22±2.92mg.kg -1 ; 0.5mg.kg -1 .minute -1 , respectively). Mechanical ventilation using time cycle was started. PH was induced by administration of serotonin (5HT) (10µg.kg -1 and 1mg.kg -1 .hour -1 ) through a thermodilution catheter positioned in the pulmonary artery. The measurements were performed before administration of 5HT (T0), after 30 minutes (T30), then at 15-minute intervals (T45, T60, T75 and T90). No differences between groups were registered for systolic (sPAP) and mean pulmonary arterial pressure (mPAP), mean arterial pressure (MAP), total peripheral resistance index (TPRI) and pulmonary vascular resistance index (PVRI). In PG, sPAP and mPAP increased from T30. While in TG, sPAP and mPAP increased from T75. In PG, heart rate (HR) increased from T30, in which PG was higher than TG. The TPRI values decreased from T30 in PG, and in TG, at T45, T60 and T90. In PG, at T0, PVRI was lower than at other times. In PG, arterial partial pressures of oxygen (PaO 2 ) decreased from T60 and alveolar-arterial oxygen gradient (PA-aO 2 ) increased at T60. In TG, at T0 PaO 2 was higher than at T30, T45, T60 and T90, while PA-aO 2 at T0 was lower than at T90. From T30 to T90, TG showed higher PaO 2 means and lower arterial partial pressures of carbon dioxide (PaCO 2 ) values when compared to PG. In PG, from T30, PaCO 2 increased, while in TG this parameter was stable. In conclusion, thiopental anesthesia attenuated the cardiopulmonary changes resulting from serotonin-induced PH, probably by attenuation of vasoconstriction and bronchoconstriction.

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“…Numerous studies have identified that propofol has vasodilatory properties in vivo [ 28 ] and in vitro [ 6 , 29 , 30 ]. Moreover, in sensory neurons and heterologous expression systems, propofol has been demonstrated to activate and modify TRPA1 ion channel sensitivity to agonist activation [ 13 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…It may involve direct modulation of vascular tone in an endothelium-dependent or endothelium-independent manner depending on the species (rat, pig, and human) and vascular bed (thoracic and coronary) from which the arterioles were obtained [ 18 ]. Specifically, endothelial denuding [ 30 , 32 ] and e-NOS inhibition [ 6 ] resulted in sustained dilation by propofol, whereas Klockgether et al [ 5 ] demonstrated a role for BK channels in the response.…”

Section: Discussionmentioning

confidence: 99%

TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels

Melo

Oliveira-Paula

Ferezin

et al. 2022

CIMB

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Anesthesia with propofol is frequently associated with hypotension. The TRPA1 gene contributes to the vasodilator effect of propofol. Hypotension is crucial for anesthesiologists because it is deleterious in the perioperative period. We tested whether the TRPA1 gene polymorphisms or haplotypes interfere with the hypotensive responses to propofol. PCR-determined genotypes and haplotype frequencies were estimated. Nitrite, nitrates, and NOx levels were measured. Propofol induced a more expressive lowering of the blood pressure (BP) without changing nitrite or nitrate levels in patients carrying CG+GG genotypes for the rs16937976 TRPA1 polymorphism and AG+AA genotypes for the rs13218757 TRPA1 polymorphism. The CGA haplotype presented the most remarkable drop in BP. Heart rate values were not impacted. The present exploratory analysis suggests that TRPA1 genotypes and haplotypes influence the hypotensive responses to propofol. The mechanisms involved are probably other than those related to NO bioavailability. With better genetic knowledge, planning anesthesia with fewer side effects may be possible.

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Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments

Cited by 13 publications

References 39 publications

Influence of blood pressure on cardio-ankle vascular index (CAVI) examined based on percentage change during general anesthesia

Influence of blood pressure on cardio-ankle vascular index (CAVI) examined based on percentage change during general anesthesia

Cardiopulmonary parameters in propofol- or thiopental-anesthetized dogs induced to pulmonary hypertension by serotonin

TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels

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