Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery †

Anesthetics and other products used during the perioperative period may influence immune function not only merely by reducing the HPA-axis stress response but also by directly modulating innate and adaptive immune responses. Most of the literature on the immune effects of anesthetics has been derived from in vitro or animal studies, due to the number of confounding variables in “real life” surgical settings. These immunosuppressive effects might not normally have clinical consequences for an immune-competent patient, but may act as important modifiers in postoperative morbidity and mortality. Furthermore, some inhibitory effects on neutrophil functions may provide a therapeutically beneficial effect under specific surgical clinical conditions, such as ischemia-reperfusion injury.

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“…This effect has also been demonstrated in other human studies using different markers of lipid peroxidation (44).…”

Section: Intravenous Anaestheticssupporting

confidence: 74%

Immunological Modifications Induced from Products Used during the Perioperative Period

Cardinale

Mastrototaro

Cappiello

et al. 2011

Int J Immunopathol Pharmacol

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“…It has also been shown that propofol can attenuate apoptosis in tumor necrosis factor-α-induced endothelial cells and enhance the bioavailability of nitric oxide (Luo et al, 2005). Coronary endothelial cell apoptosis precedes myocyte apoptosis (Sayin et al, 2002). Hence, attenuation of vascular endothelial cell apoptosis by propofol could have resulted in reduced cardiomyocytes apoptosis during myocardial ischemia and reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane

Xing

Lü

et al. 2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: We compare the cardioprotective effects of anesthetic preconditioning by propofol and/or isoflurane in rats with ischemia-reperfusion injury. Methods: Male adult Wistar rats were subjected to 60 min of anterior descending coronary artery occlusion followed by 120 min of reperfusion. Before the long ischemia, anesthetics were administered twice for 10 min followed by 5 min washout. Isoflurane was inhaled at 1 MAC (0.016) in I group, whereas propofol was inhaled intravenously at 37.5 mg/(kg⋅h) in P group. A combination of isoflurane and propofol was administered simultaneously in I+P group. Results: In control (without anesthetic preconditioning, C group), remarkable myocardial infarction and apoptosis accompanied by an increased level of cardiac troponin T were noted 120 min after ischemia-reperfusion. As compared to those of control group, I and P groups had comparable cardioprotection. In addition, I+P group shares with I and P groups the comparable cardioprotective effects in terms of myocardial infarction and cardiac troponin T elevation. Conclusion: A combination of isoflurane and propofol produced no additional cardioprotection.

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“…The result showed TBARS level was less signiicantly in propofol group than fentanyl group. (19) The second study included thirty adult patients referred for elective cardiac procedure with Cardio Pulmonary Bypass (CPB) and randomly allocated to a propofol group or a control group. Patients in the propofol group received propofol 0.1 mg/kg/minute intravenously for anesthesia maintenance, whereas those in the control group received fentanyl 10 µg/kg intravenously and inhaled enlurane 1%-1.5%.…”

Section: Effect To Respiratory Systemmentioning

confidence: 99%

Propofol Effect on Stress Response and Free Radicals in Patient during Surgery and Sedation Procedure

Rahardjo

2015

Indones Biomed J

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BACKGROUND: Propofol is an intravenous anesthetic used worldwide as an anesthesia induction and maintenance agent. Propofol also used as sedation agent in Intensive Care Unit (ICU). Despite it’s usual anesthesia properties, propofol has an unique pharmacologic characteristic, especially as antioxidant and stress response reduction. These advantages suggested propofol has positive effects when used as an anesthesia agent in surgery or sedation in ICU in conditions when high stress and free radical level are released.CONTENT:Stress response and free radical can be elevated in various conditions including surgery or during care in ICU, especially critical ill patient. Cortisol is a major stress hormone that influences metabolism, cardiovascular and central nervous system, either in acute or chronic phase. Oxidative stress was marked by free radical elevation called Radical Oxygen Species (ROS). Combination of both elements (cortisol and ROS) can worsen patient condition. Propofol with anti-stress and antioxidant properties could be used to reduce stress response and attenuate free radical level in order to improve patient condition.SUMMARY: The anti-stress and antioxidant properties of Propofol are interesting, because these benefits can be added as adjunctive therapy when propofol was used as an anesthetic agent in surgery and a sedation in ICU.KEYWORDS: propofol, stress response, antioxidant

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Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery †

Abstract: In clinical doses, propofol strongly attenuates lipid peroxidation during CABG surgery.

Cited by 75 publications

References 29 publications

Immunological Modifications Induced from Products Used during the Perioperative Period

Immunological Modifications Induced from Products Used during the Perioperative Period

Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane

Propofol Effect on Stress Response and Free Radicals in Patient during Surgery and Sedation Procedure

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