Propofol/Sufentanil Anesthesia Suppresses the Metabolic and Endocrine Response During, Not After, Lower Abdominal Surgery

The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy

“…Although none of the patients suffered from pain at 120 minutes after recovery from anesthesia, plasma cortisol and glucose levels were still high in both groups. These results were in an agreement with those of Schricker et al 17 who reported that nociceptive pathways are partially responsible for the activation of the stress response.…”

The effect of ulinastatin on hyperglycemia in patients undergoing hepatectomy

“…Therefore, theoretically, any intervention that regulates the neuroendocrine stress response and release of cytokines perioperatively can also modulate the consequent dysglycemia and mitigate perioperative hyperglycemia. Similar effects of propofol or opioids have been reported [7].…”

Remifentanil for cesarean section under general anesthesia: effects on maternal stress hormone secretion and neonatal well-being: a randomized trial

“…Opioids are known to reduce the hypothalamic-adrenal response to surgery, 26 and to depress sympathetic activity in a dose-dependent manner. 27,28 Although norepinephrine secretion has been shown to be reduced by opioid administration, 29 in our study the increase in norepinephrine was not attenuated by remifentanil infusion, as previously described.…”