The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy

Demirbilek, Semra; Ganidagli, Suleyman; Aksoy, Nurten; Becerik, Cevdet; Baysal, Zeynep

doi:10.1016/j.jclinane.2003.10.002

Cited by 20 publications

(14 citation statements)

References 17 publications

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“…Keeping records of the range of glucose in the blood in proportion to the baseline values, its level increased in all 3 groups, but the greatest deviations were recorded in the fentanyl group, as was also found by Demirbilek et al (9).…”

Section: Discussionsupporting

confidence: 77%

Stress indicators during general anesthesia with opioid analgesics in children

Drašković¹,

Stanic²,

Uram-Benka³

et al. 2014

Turk J Med Sci

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Background/aim: To determine which of the applied opioid analgesics brings the most powerful blockade of the stress response with the fewest side effects in children. Materials and methods:This was a prospective, observational clinical study. The study included 150 boys, aged 2-5 years, ASA I, who underwent herniectomy or orchidopexy in day case surgery. The introduction and maintenance of anesthesia was intravenous (propofol, rocuronium, and opioids); airway was maintained by laryngeal mask and ventilation by mixture of oxygen/air. Subjects were divided into 3 groups depending on the applied opioid analgesics (fentanyl, alfentanil, remifentanil). Results:The fentanyl group had the highest blood glucose values (AS = 5.14; SD = 0.47) and the highest increase in cortisone level at the moment of incision and at awakening (AS = 536.09; SD = 198.56). The lowest increase in cortisone was recorded in the remifentanil group. A significant decrease in leptin was registered at awakening in the fentanyl group and at the moment of incision in the remifentanil group (P = 0.939). Conclusion:Remifentanil is the opioid analgesic with the highest suppressing effect on the stress response to surgical intervention in children.

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Section: Discussionsupporting

confidence: 77%

Stress indicators during general anesthesia with opioid analgesics in children

Drašković¹,

Stanic²,

Uram-Benka³

et al. 2014

Turk J Med Sci

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“…On the other hand, TIVA is usually performed with propofol, a short-acting intravenous anesthetic, in combination with opioids [1,3,5,7,8]. In recent years, both regimes have often been used for the anesthetic management of ambulatory and other surgeries [1,3,5,6,8]. There have been some reports comparing these regimes with regard to quality of anesthesia, recovery, postoperative nausea and vomiting, and cost [1,3,5].…”

Section: Introductionmentioning

confidence: 99%

Different effects on circulatory control during volatile induction and maintenance of anesthesia and total intravenous anesthesia: autonomic nervous activity and arterial cardiac baroreflex function evaluated by blood pressure and heart rate variability analysis

Ogawa

Iwasaki

Shibata

et al. 2006

Journal of Clinical Anesthesia

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“…In addition to providing analgesia, amnesia, and immobility, anesthetics also appear to play a pivotal role in immune function and inflammation. Recent studies have shown that anesthetic agents modify the neuroendocrine stress response to various operative procedures by decreasing adrenocorticotropic hormone, cortisol, adrenaline, noradrenaline, and growth hormone levels (1,18). Anesthetics have also been found to maintain the balance between Th1 and Th2 immune responses (27), which is altered in critically ill patients (33,37).…”

mentioning

confidence: 99%

General Anesthesia Delays the Inflammatory Response and Increases Survival for Mice with Endotoxic Shock

Fuentes

Talamini

Fulton

et al. 2006

Clin Vaccine Immunol

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Anesthesia is an indispensable component of any operative procedure. In this study, we demonstrate that continuous isoflurane anesthesia for 1 h after a lethal dose (20 mg/kg of body weight) of Escherichia coli lipopolysaccharide (LPS) results in a significant increase in survival of C57BL/6J (B6) mice in comparison with survival of nonanesthetized mice. Protection by anesthesia correlates with a delay in plasma LPS circulation, resulting in a delayed inflammatory response, particularly DNA binding activity of NF-B and serum levels of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10. Disparate classes of anesthetic agents produce the same effects on the inflammatory response, which is also independent of the inbred mouse strain used. These results suggest that anesthesia has an important impact on the outcome from endotoxemia. Moreover, the immunomodulatory effects of anesthetics should be considered when interpreting data from experimental animal models.

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The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy

Cited by 20 publications

References 17 publications

Stress indicators during general anesthesia with opioid analgesics in children

Stress indicators during general anesthesia with opioid analgesics in children

Different effects on circulatory control during volatile induction and maintenance of anesthesia and total intravenous anesthesia: autonomic nervous activity and arterial cardiac baroreflex function evaluated by blood pressure and heart rate variability analysis

General Anesthesia Delays the Inflammatory Response and Increases Survival for Mice with Endotoxic Shock

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