Proportion of deproteinized bovine bone and autogenous bone affects bone formation in the treatment of calvarial defects in rabbits

Pripatnanont, Prisana; Nuntanaranont, Thongchai; Vongvatcharanon, Surapong

doi:10.1016/j.ijom.2009.02.015

Cited by 38 publications

(45 citation statements)

References 8 publications

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“…Demineralized bovine bone is one of the most well established among those substitutes. It presents osteoconductivity property, biocompatibility and its structure is similar to human bone 5 . On other hand, calcium phosphate bone substitutes has been widely researched due to its mineral characteristic similar to human bone: it is bioactive, biodegradable and it presents osteoconductive properties, although not osteoinductivity 6 .…”

Section: Introductionmentioning

confidence: 98%

The biopolymer sugarcane as filling material of critical defects in rats

Abreu

Lima²,

Souza

et al. 2016

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of particulate (granule-shaped) SCB on bone repair relating it to its biocompatibility and bone neoformation. METHODS:Thirty Wistar rats were submitted to a one 7-mm-diameter defect and divided equally into three experimental groups, with two different postoperative times of evaluation, 90 and 120 days. Each calvaria defect was filled up with clot (control group), particulated autogenous bone or granulated SCB. Five animals of each group were assessed at 90 and 120 days after surgery. In these two periods, histological and histometric analysis were obtained. RESULTS:The clot group showed a bone resorption trend while the autogenous bone group a bone repair trend. However in the SCB group, the critical defect filled up only with fibrous connective tissue and presented none bone neoformation. CONCLUSION:The sugarcane biopolymer when used in critical size defects was a biocompatible material and proved to be a good material to fill bone cavities, keeping them as uniform areas filled with soft tissue and avoiding the tissue shrinkage.

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Section: Introductionmentioning

confidence: 98%

The biopolymer sugarcane as filling material of critical defects in rats

Abreu

Lima²,

Souza

et al. 2016

Acta Cir. Bras.

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“…In the face of a major bone defect, the organism becomes unable to regenerate bone and, unless other methods contribute their bone-repairing capacity, will produce scarring by fibrous tissue (2,3). A study on bone transplants concluded that autogenous bone is the best material for grafting (4)(5)(6). It is known, however, that this type of graft has a number of disadvantages, such as the use of a distant surgical donor area, postoperative discomfort, scars, longer duration e191 of surgery and the risk of infection (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Histological evaluation of bone repair using beta-Tricalcium Phosphate

Frota¹,

Va²,

Teixeira³

et al. 2011

Med Oral

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Objectives: The aim of the present study was to evaluate bone repair in defects induced in the cranium of Wistar rats using β-tricalcium phosphate. Study Design: In this research, we used 30 rats, randomly distributed in three groups of 10 animals (G1, G2 and G3), corresponding respectively to time of histological evaluation (7, 15 and 30 days). This was a paired study, a defect being induced in the parietal bone on either side of the median sagittal suture of the animals, being the left-hand side the experimental subgroup (filled by biomaterial) and the right control. The histological evaluation was performed by means of light microscopy. The collected data were submitted to the Fisher Exact test for comparison between the groups and to the McNemar test for comparison between the subgroups (P > 5%). Results: The results showed no statistically significant differences between the groups and bone regeneration was similar at the different times of evaluation. Conclusions: Therefore, we concluded that β-tricalcium phosphate has not contributed significantly to repair process of defects induced in the cranium of Wistar rats.

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“…It was revealed that the addition of deproteinized bovine bone to autogenous grafts increased the mean optical density of newly formed skeletal tissue, with a simultaneous decrease in its content in bone defects (skullcap). The opposite effects were observed when autogenous bone graft was used alone (Pripatnanont et al, 2009). Using a mixture of allogenic bone and deproteinized bovine bone (BioOss ® /Orthoblast II ® ) for the purposes of maxillary sinus lift did not have results as satisfactory as with the application of deproteinized animal bone or synthetic bone (Osteon ® ) alone.…”

Section: Discussionmentioning

confidence: 91%

“…Attempts at bone replacement with materials obtained by combining autogenous bone and deproteinized bovine bone constitute another example of the potential optimization of biological conditions for new skeletal tissue growth within a skeletal defect. The inclusion of autogenous material with osteoinductive properties in such composites results in the enhanced formation of better quality bone Pripatnanont et al, 2009;Thorwarth et al, 2006;Thuaksuban et al, 2010). In vitro cellular studies have confirmed that allogenic materials of human origin (demineralized bone matrix, deproteinized bone) may also have some osteoinductive activity.…”

Section: Introductionmentioning

confidence: 97%