Proposta de questionário para caracterização da prevalência de sintomas digestivos nas doenças difusas do tecido conjuntivo

Machado, Wellington Monteiro; Freire, Beatriz Funayama Alvarenga; Rocha, Oswaldo Melo da; Azambuja, Carlos; Oliveira, Maria Elisa C.

doi:10.1590/s0004-28032004000100013

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…regurgitation, heartburn, nausea, vomiting, abdominal distension and pain in the upper abdominal region. [8][9][10][11][12][13] Despite this diversity of digestive symptoms, there are currently no studies analyzing the possible anatomical alterations found in the upper gastrointestinal tract of patients with DM. In cases of juvenile DM, vascular abnormalities in gastroduodenal mucosa, as well as bioelectric activity of gastric muscles, have been described.…”

Section: ■ Resultsmentioning

confidence: 99%

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Amorim¹,

Furuya²,

Marques³

et al. 2017

Medical Express

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OBJECTIVE:To endoscopically assess the upper digestive tract of adult patients with newly diagnosed dermatomyositis; to correlate possible changes in the gastrointestinal tract with demographic, clinical and laboratory features in this population. METHOD: A cross-sectional study evaluating 65 newly diagnosed dermatomyositis cases from 2004 to 2015 was carried out. We excluded patients with clinically amyopathic dermatomyositis, overlap dermatomyositis, polymyositis, liver diseases, prior gastric surgery, upper gastrointestinal tract symptoms (except for upper dysphagia), systemic infections, alcohol consumption and smoking. RESULTS: Mean age of patients was 44.9 years, with disease duration of four months. Endoscopic findings were observed in 70.8% of patients. (1) Esophageal disease/gastric distress was documented in 18.5% of patients: erosive distal esophagitis (16.9%) and non-erosive distal esophagitis distal (1.5%); (2) gastric distress in 63.1% of cases: antral gastritis (42.3%) and pangastritis (27.8%); (3) duodenal involvement in 15.4% of patients: bulbar duodenitis (10.9%) and duodenal ulcers (7.7%). There were no neoplasic lesions. On multivariate analysis, erosive distal esophagitis was less associated with older patients. Males had a higher prevalence of erosive gastritis. Enanthematous pangastritis was less associated with lesions with "V-neck" sign lesions. CONCLUSIONS: This study provides the first estimates of the prevalence of high endoscopic findings in adult patients with newly diagnosed dermatomyositis. The results may be relevant to guide conduct in digestive disorders with upper digestive endoscopy, and point to the need for pharmacological prevention of digestive tract lesions in these patients. Further studies are needed to validate this data and evaluate patients with dyspeptic symptoms.

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Section: ■ Resultsmentioning

confidence: 99%

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Amorim¹,

Furuya²,

Marques³

et al. 2017

Medical Express

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“…Underlying vasculitis was demonstrated in 50% of them. 2,3,4,5,6 The vasculitis usually affects small vessels of the intestinal wall. The histological assessment demonstrates atrophy and degeneration of the media, fibrinoid necrosis, thrombosis and lymphocytic infiltrate in lamina propria; the immunohistochemical analysis shows deposit of immune complexes, complement and fibrinogen.…”

Section: Discussionmentioning

confidence: 99%

“…Gastrointestinal tract vasculitis is almost always accompanied by activity in other organs, such as skin, kidneys and CNS. 2,3,4,5 PI is usually asymptomatic; however, the cysts can rupture and cause pneumoperitoneum. 1,9,10 There seems to be an association between new leukopenia and thrombocytopenia or worsening of the pre-existing leukopenia with intestinal vasculitis.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,5,15 Cyclophosphamide pulse therapy, 0.75-1 g/m, is indicated in refractory cases. 2,4,13 There have been reports on the use of inhaled oxygen or hyperbaric chamber in an attempt to remove the gas from the cysts and of octreotide to improve motility and reduce bacterial overgrowth. 10 Prognosis is poorer when there is surgical indication, which can be improved when the procedure is performed early.…”

Section: Discussionmentioning

confidence: 99%

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Lúpus eritematoso sistêmico complicado por vasculite intestinal e pneumatose intestinal

Marinello¹,

Rafael²,

Paiva³

et al. 2010

Rev. Bras. Reumatol.

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Gastrointestinal manifestations in systemic lupus erythematosus (SLE) are not uncommon. Non specific symptoms are often observed, such as abdominal pain, nausea, vomiting and diarrhea. On the other hand, pneumatosis cystoides intestinalis, which is characterized by multiple gas-filled cysts located throughout the intestinal wall, is a rare condition in SLE. We describe a case of a 20-year-old man who was admitted with fever, weight loss, headache and arthralgia and had a diagnosis of systemic lupus erythematosus. During his hospital stay, he developed abdominal symptoms that suggested intestinal vasculitis. The computed tomography of the abdomen showed the double halo sign, or target sign and pneumatosis cystoides intestinalis. The patient presented complete recovery after conservative treatment, with intestinal rest and total parenteral nutrition.

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“…As alterações provocadas no trato gastrintestinal, embora dependam do tipo de doença difusa do tecido conjuntivo, podem conduzir à desnutrição, uma vez que interferem na ingestão e absorção dos nutrientes (MACHADO et al, 2004). Dentre essas alterações, pode-se citar: anormalidades da cavidade oral, como limitação na abertura da boca (por alteração da articulação temporomandibular), dor ao mastigar e dificuldade de deglutição, seja por complicações da própria doença reumática ou como conseqüência da Síndrome de Sjogren; disfunção esofagiana com disfagia ou odinofagia, má absorção e enteropatia perdedora de proteínas (GALPERIN; GERMAN; GERSHEIN, 2003).…”

Section: Introductionunclassified

Indicadores antropométricos e risco para doenças cardiovasculares em mulheres com doenças reumáticas

Koehnlein

Bennemann

2009

Semin. Cienc. Biol. Saude

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ResumoO objetivo deste trabalho foi avaliar o estado nutricional e o risco para doenças cardiovasculares de mulheres com doenças reumáticas em uma associação de apoio ao reumático de Maringá-PR. O estado nutricional foi determinado por meio do Índice de Massa Corporal (IMC) e o risco para doenças cardiovasculares a partir da razão cintura-quadril (RCQ) e da circunferência da cintura isolada (CC). Foram avaliadas 43 mulheres, sendo 11 adultas e 32 idosas. A maioria (60,46%) das mulheres avaliadas apresentou excesso de peso, 32,56% apresentaram peso adequado e 6,98% (3 idosas) apresentaram baixo peso. O risco para doenças cardiovasculares foi observado em 48,84% das mulheres, de acordo com a avaliação pela RCQ. Já a avaliação da CC isolada demonstrou que 83,72% das mulheres apresentavam risco. Conclui-se que a prevalência de excesso de peso e de risco para doenças cardiovasculares é preocupante nesta população, não apenas em decorrência das complicações associadas, mas pelo agravamento ainda maior na qualidade de vida desses indivíduos. Palavras-chave: Doenças reumáticas. Índice de massa corporal. Razão cintura-quadril.Circunferência da cintura. Risco para doenças cardiovasculares. AbstractThe purpose of this work was to evaluate the nutritional status and the risk for cardiovascular diseases in women with rheumatic diseases from an association for patients with rheumatic diseases in Maringá -PR. The nutritional status was determined by means of the Body Mass Index (BMI) and the risk for cardiovascular diseases based on the waist-to-hip ratio (WHR) and the isolated waist circumference (WC). Forty-three women were evaluated, being 11 adults and 32 elderly. Most of the evaluated women (60.46%) showed to be overweight, 32.56% had appropriate body weight and 6.98% had low weight. The risk for cardiovascular diseases was observed in 48.84% of the women, according to the waist-tohip evaluation. The isolated WC showed that 83.72% of the women had risk of cardiovascular diseases. It is concluded that the prevalence of overweight and risk for cardiovascular diseases is worrying for this population, not only because of the associated complications, but also for the worsening in the life quality of these individuals.

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Proposta de questionário para caracterização da prevalência de sintomas digestivos nas doenças difusas do tecido conjuntivo

Cited by 5 publications

References 27 publications

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Lúpus eritematoso sistêmico complicado por vasculite intestinal e pneumatose intestinal

Indicadores antropométricos e risco para doenças cardiovasculares em mulheres com doenças reumáticas

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