Propranolol enhances in vitro interleukin 2 receptor expression on human lymphocytes

Malec, P; Nowak, Zofia

doi:10.1016/0165-2478(88)90004-1

Cited by 7 publications

(2 citation statements)

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“…[5][6][7][8] Consistently, hormonal and neurotransmitter receptors have been described in a variety of immunohematopoietic cells. 6,[9][10][11] In the past several years, our contribution in this field has been focused on the hematopoietic role of the pineal hormone melatonin and of catecholamines. Accordingly, F IGURE 1 shows a scheme of the hematopoietic microenvironment with catecholamines and melatonin highlighted.…”

Section: Introductionmentioning

confidence: 99%

Neurohormones and Catecholamines as Functional Components of the Bone Marrow Microenvironment

Maestroni

2000

Annals of the New York Academy of Sciences

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A BSTRACT : A variety of cytokines and growth factors exert a finely tuned control on the complex series of proliferative and differentiative events called hematopoiesis. Recent studies have shown that neuroendocrine and neural factors may also regulate hematopoiesis. In particular, besides its important immunoenhancing properties, the pineal neurohormone melatonin can also rescue hematopoiesis from the toxic effect of anti-cancer drugs via the action of T-helper cell novel opioid cytokines. In turn, these substances bind -opioid receptors expressed in GM-CSF-activated macrophage-like stromal cells and seem to stimulate IL-1. Adrenergic agents can also affect hematopoiesis. We demonstrated that pre-B cells express ␣ 1B -adrenoceptors ( ␣ 1B -AR) and that their activation by catecholamines results in suppressed myelopoiesis in vitro or protection in vivo against supralethal doses of carboplatin. Most recently, we found that ␣ 1B -AR gene knockout mice show a deranged hematopoietic recovery after sublethal irradiation. Regeneration of pre-B cells (the cell type expressing ␣ 1B -AR) and of erythrocytes was much faster in knockout than in wild-type mice. Most interesting, bone marrow cells can synthesize both melatonin and catecholamines. As far as melatonin is concerned, human and murine bone marrow cells contain and synthesize melatonin at a concentration that is three orders of magnitude higher than that normally found in serum. Catecholamines are also present in substantial amounts and originate both from nerve endings and bone marrow cells. These findings open interesting new perspectives and include hematology among the disciplines that would benefit from the integrative NIM approach.

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Section: Introductionmentioning

confidence: 99%

Neurohormones and Catecholamines as Functional Components of the Bone Marrow Microenvironment

Maestroni

2000

Annals of the New York Academy of Sciences

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“…At present, several neuroendocrine pathways affecting the immune homeostasis are distinguished, one of which is the hypothalamus--fasciculus longitudinalis--postganglionar sympathetic fibers--lymphoid cells axis [8]. The sympathetic component of the autonomic nervous system is widely presented in lymphoid organs [4], and catecholamines produced by nerve endings regulate proliferation and differentiation of immunocompetent cells via specific membrane receptors [7,9,11]. On the other hand, lymphoid cells produce neuroactive substances, including catecholamines [2].…”

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confidence: 99%

Daily variations of epinephrine, norepinephrine, and β-adrenoceptors in the blood and lymphoid organs of intact rats

et al. 1999

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Daily variations of catecholamine concentrations in the blood and lymphoid organs in Wistar rats were revealed. Daily fluctuations of epinephrine and norepinephrine levels in the spleen and blood were synchronous. Circadian variations of epinephrine in the thymus, lymph nodes, and plasma were synphasic. A relationship between neurotransmitter concentrations and expression of [3-adrenoceptors on thymic and splenic lymphocytes was noted. Key Words: epinephrine; norepinephrine; ~-adrenoceptors," biorhythms," lymphocytesNeuroimmune relationships is a pressing problem within the framework of regulation of the immune functions. At present, several neuroendocrine pathways affecting the immune homeostasis are distinguished, one of which is the hypothalamus--fasciculus longitudinalis--postganglionar sympathetic fibers--lymphoid cells axis [8]. The sympathetic component of the autonomic nervous system is widely presented in lymphoid organs [4], and catecholamines produced by nerve endings regulate proliferation and differentiation of immunocompetent cells via specific membrane receptors [7,9,11]. On the other hand, lymphoid cells produce neuroactive substances, including catecholamines [2]. The role of lympho-and monokines in the realization of immunoneuroendocrine relationships has been demonstrated [6].The functions of the immune and neuroendocrine systems are characterized by biological rhythms of activity [3,10]. However, reports about the temporal aspects of neuroimmune relationships are scanty. We investigated the circadian rhythms of epinephrine, nor-

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Norepinephrine, the β-Adrenergic Receptor, and Immunity

Sanders

Straub

2002

Brain, Behavior, and Immunity

249

135

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Propranolol enhances in vitro interleukin 2 receptor expression on human lymphocytes

Cited by 7 publications

References 11 publications

Neurohormones and Catecholamines as Functional Components of the Bone Marrow Microenvironment

Neurohormones and Catecholamines as Functional Components of the Bone Marrow Microenvironment

Daily variations of epinephrine, norepinephrine, and β-adrenoceptors in the blood and lymphoid organs of intact rats

Norepinephrine, the β-Adrenergic Receptor, and Immunity

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