“…Personalized 3D printing technology is also a relatively new technology (Kumar Gupta et al, 2022), therefore, there are still certain obstacles in the supervision of printing products. Relevant laws and regulations need to be established and improved to ensure the sustainable development of 3D printing technology (Prabhakaran et al, 2022). These limitations may also become a research hotspot in the future of 3D printing bioink in the field of bone tissue engineering.…”
Section: Research Hotspots and Prospectsmentioning
Background: Applying 3D printed bioink to bone tissue engineering is an emerging technology for restoring bone tissue defects. This study aims to evaluate the application of 3D printing bioink in bone tissue engineering from 2010 to 2022 through bibliometric analysis, and to predict the hotspots and developing trends in this field.Methods: We retrieved publications from Web of Science from 2010 to 2022 on 8 January 2023. We examined the retrieved data using the bibliometrix package in R software, and VOSviewer and CiteSpace were used for visualizing the trends and hotspots of research on 3D printing bioink in bone tissue engineering.Results: We identified 682 articles and review articles in this field from 2010 to 2022. The journal Biomaterials ranked first in the number of articles published in this field. In 2016, an article published by Hölzl, K in the Biofabrication journal ranked first in number of citations. China ranked first in number of articles published and in single country publications (SCP), while America surpassed China to rank first in multiple country publications (MCP). In addition, a collaboration network analysis showed tight collaborations among China, America, South Korea, Netherlands, and other countries, with the top 10 major research affiliations mostly from these countries. The top 10 high-frequency words in this field are consistent with the field’s research hotspots. The evolution trend of the discipline indicates that most citations come from Physics/Materials/Chemistry journals. Factorial analysis plays an intuitive role in determining research hotspots in this sphere. Keyword burst detection shows that chitosan and endothelial cells are emerging research hotspots in this field.Conclusion: This bibliometric study maps out a fundamental knowledge structure including countries, affiliations, authors, journals and keywords in this field of research from 2010 to 2022. This study fills a gap in the field of bibliometrics and provides a comprehensive perspective with broad prospects for this burgeoning research area.
“…Personalized 3D printing technology is also a relatively new technology (Kumar Gupta et al, 2022), therefore, there are still certain obstacles in the supervision of printing products. Relevant laws and regulations need to be established and improved to ensure the sustainable development of 3D printing technology (Prabhakaran et al, 2022). These limitations may also become a research hotspot in the future of 3D printing bioink in the field of bone tissue engineering.…”
Section: Research Hotspots and Prospectsmentioning
Background: Applying 3D printed bioink to bone tissue engineering is an emerging technology for restoring bone tissue defects. This study aims to evaluate the application of 3D printing bioink in bone tissue engineering from 2010 to 2022 through bibliometric analysis, and to predict the hotspots and developing trends in this field.Methods: We retrieved publications from Web of Science from 2010 to 2022 on 8 January 2023. We examined the retrieved data using the bibliometrix package in R software, and VOSviewer and CiteSpace were used for visualizing the trends and hotspots of research on 3D printing bioink in bone tissue engineering.Results: We identified 682 articles and review articles in this field from 2010 to 2022. The journal Biomaterials ranked first in the number of articles published in this field. In 2016, an article published by Hölzl, K in the Biofabrication journal ranked first in number of citations. China ranked first in number of articles published and in single country publications (SCP), while America surpassed China to rank first in multiple country publications (MCP). In addition, a collaboration network analysis showed tight collaborations among China, America, South Korea, Netherlands, and other countries, with the top 10 major research affiliations mostly from these countries. The top 10 high-frequency words in this field are consistent with the field’s research hotspots. The evolution trend of the discipline indicates that most citations come from Physics/Materials/Chemistry journals. Factorial analysis plays an intuitive role in determining research hotspots in this sphere. Keyword burst detection shows that chitosan and endothelial cells are emerging research hotspots in this field.Conclusion: This bibliometric study maps out a fundamental knowledge structure including countries, affiliations, authors, journals and keywords in this field of research from 2010 to 2022. This study fills a gap in the field of bibliometrics and provides a comprehensive perspective with broad prospects for this burgeoning research area.
“…Aqueous HA solutions have a low viscous modulus, which means they cannot retain their shape or provide adequate yield stress during printing. Therefore, HA is typically mixed with other polymers to produce bioinks for droplet printing [ 125 ]. Fig.…”
Section: Ha-based Bioinks For 3d Printingmentioning
confidence: 99%
“…The resolution of LAB matches the size of individual cells, making it a promising tool for simulating the heterogeneity and structural characteristics of skin. It is therefore used in autograft facial surgery by printing simulated skin for plastic surgery [ 125 ]. LAB workstations can be set up in sterile operating rooms to provide personalized and “tailor-made” treatment [ 141 ].…”
Section: Ha-based Bioinks For 3d Printingmentioning
Hyaluronic acid (HA) is widely distributed in human connective tissue, and its unique biological and physicochemical properties and ability to facilitate biological structure repair make it a promising candidate for three-dimensional (3D) bioprinting in the field of tissue regeneration and biomedical engineering. Moreover, HA is an ideal raw material for bioinks in tissue engineering because of its histocompatibility, non-immunogenicity, biodegradability, anti-inflammatory properties, anti-angiogenic properties, and modifiability. Tissue engineering is a multidisciplinary field focusing on in vitro reconstructions of mammalian tissues, such as cartilage tissue engineering, neural tissue engineering, skin tissue engineering, and other areas that require further clinical applications. In this review, we first describe the modification methods, cross-linking methods, and bioprinting strategies for HA and its derivatives as bioinks and then critically discuss the strengths, shortcomings, and feasibility of each method. Subsequently, we reviewed the practical clinical applications and outcomes of HA bioink in 3D bioprinting. Finally, we describe the challenges and opportunities in the development of HA bioink to provide further research references and insights.
Graphical Abstract
“…Three-dimensional bioprinting in the modern sense mainly refers to the utilization of cells/cell clusters, bioactive factors and biomaterials as raw materials, which are printed layer by layer by 3D printing to construct bionic tissues or organ transplants with threedimensional structures and biological functions. [2][3][4] However, the irregular shape of many defect sites, the difficulty of perfectly matching the printed gra to the shape of the defect, and the potential for the gra to fail to adjust to the extremely complex and delicate internal environment of the human body aer implantation are obstacles to the progress of in vitro bioprinting techniques. [5][6][7] On the basis of inkjet bioprinting, Campbell 8 initially proposed the idea of "in situ bioprinting," which has since gained much attention in the areas of clinical medicine, regenerative medicine, and tissue engineering.…”
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