Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

Arjmand, Babak; Sarvari, Masoumeh; Alavi-Moghadam, Sepideh; Payab, Moloud; Goodarzi, Parisa; Gilany, Kambiz; Mehrdad, Neda; Larijani, Bagher

doi:10.3389/fendo.2020.00430

Cited by 63 publications

(36 citation statements)

References 140 publications

(164 reference statements)

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“…Many cases involve bone diseases and conditions, such as osteoarthritis, osteogenesis imperfecta, rheumatoid arthritis, and osteoporosis. Research efforts will be made in the future to clarify the clinical application of MSCs in osteoporosis [ 185 ].…”

Section: Therapeutic Approach and Novel Strategiesmentioning

confidence: 99%

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Noh

Yang

Jung

2020

IJMS

184

121

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Osteoporosis is the most common chronic metabolic bone disease. It has been estimated that more than 10 million people in the United States and 200 million men and women worldwide have osteoporosis. Given that the aging population is rapidly increasing in many countries, osteoporosis could become a global challenge with an impact on the quality of life of the affected individuals. Osteoporosis can be defined as a condition characterized by low bone density and increased risk of fractures due to the deterioration of the bone architecture. Thus, the major goal of treatment is to reduce the risk for fractures. There are several treatment options, mostly medications that can control disease progression in risk groups, such as postmenopausal women and elderly men. Recent studies on the basic molecular mechanisms and clinical implications of osteoporosis have identified novel therapeutic targets. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for osteoporosis management in the future. Here, we review the etiology of osteoporosis and the molecular mechanism of bone remodeling, present current pharmacological options, and discuss emerging therapies targeting novel mechanisms, investigational treatments, and new promising therapeutic approaches.

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Section: Therapeutic Approach and Novel Strategiesmentioning

confidence: 99%

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Noh

Yang

Jung

2020

IJMS

184

121

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“…It was also recently reported that BM-MSC-derived exosomal miRNA-150-3p promotes osteoblast proliferation and differentiation in osteoporosis [ 201 ]. For all of this, stem cell-based therapy and their secretome-derived products are considered as a new approach to regenerate the bone tissue [ 202 ].…”

Section: New Horizons For Clinical Applications Of Mscmentioning

confidence: 99%

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Fernández-Francos

Eiró

Costa

et al. 2021

IJMS

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Around 40% of the population will suffer at some point in their life a disease involving tissue loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with current therapies. An alternative for these processes is represented by stem cells and, especially, mesenchymal stem cells (MSC). Numerous preclinical studies have shown MSC to have therapeutic effects in different clinical conditions, probably due to their mesodermal origin. Thereby, MSC appear to play a central role in the control of a galaxy of intercellular signals of anti-inflammatory, regenerative, angiogenic, anti-fibrotic, anti-oxidative stress effects of anti-apoptotic, anti-tumor, or anti-microbial type. This concept forces us to return to the origin of natural physiological processes as a starting point to understand the evolution of MSC therapy in the field of regenerative medicine. These biological effects, demonstrated in countless preclinical studies, justify their first clinical applications, and draw a horizon of new therapeutic strategies. However, several limitations of MSC as cell therapy are recognized, such as safety issues, handling difficulties for therapeutic purposes, and high economic cost. For these reasons, there is an ongoing tendency to consider the use of MSC-derived secretome products as a therapeutic tool, since they reproduce the effects of their parent cells. However, it will be necessary to resolve key aspects, such as the choice of the ideal type of MSC according to their origin for each therapeutic indication and the implementation of new standardized production strategies. Therefore, stem cell science based on an intelligently designed production of MSC and or their derivative products will be able to advance towards an innovative and more personalized medical biotechnology.

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“…Simply put, cell therapy can offer "curative" rather than palliative treatment, restoring the structure and function of bone tissue. MSCs are the best candidates on account of their anti-inflammatory and immunologic characteristics, and of their widespread bioethical acceptance [57].…”

Section: Periodontium and Pdl Cells The Periodontium Is Made Up Of Fomentioning

confidence: 99%

Gene and Cell Therapy in Dental Tissue Regeneration

Pablo¹,

Serrano²,

García-Arranz³

et al. 2022

Human Tooth and Developmental Dental Defects - Compositional and Genetic Implications

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Advanced therapies hold substantial promise for the treatment of periodontal conditions. Gene therapy has the potential to transfer “therapeutic” genes, which express proteins such as bone morphogenetic proteins, osteoprotegerin, and tissue nonspecific alkaline phosphatase, which is deficient in patients with hypophosphatasia, a condition that affects mineralization of teeth and bone. Transferred genes may also express platelet-derived growth factor, which modulates the growth of periodontal tissue and the alveolar bone. As regards cell therapy, several clinical trials have shown that mesenchymal stem cells, when used with different kinds of scaffolds to enable the required three-dimensional environment, possess a bone regeneration potential that is particularly useful in such disorders as osteoporosis and osteonecrosis, or for regenerating alveolar bone (osseointegration) prior to placing a dental implant. However, much work is still required before these new therapies become true alternatives in routine clinical dental practice. Medical advances require investments, which are usually influenced by the priorities of both politicians and society at large. This will contribute to promoting innovation, efficient treatments, medium- and long-term savings, and a higher quality of life.

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Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

Cited by 63 publications

References 140 publications

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Gene and Cell Therapy in Dental Tissue Regeneration

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