Prospective Analysis of Lipid Variations in Hyperthyroid Subjects from Lahore, Pakistan

Abstract

Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness of lipid biomarkers like LDL-C, HDL-C, TC, TG, Apo-A, and Apo-B after rehabilitation of thyroid profile attaining euthyroid state was determined. A total of 179 age-matched subjects of both genders were recruited for this research. Sixty healthy controls, thirty-four subclinical, fifty overt hyperthyroid, and thirty-five follow-up subjects having 3 months of Carbimazole therapy were enrolled. Biochemical analysis was performed by chemistry analyzer, RIA, and ELISA. One-way ANOVA was applied for the statistical analysis, while significance ( P < 0.05 ) of means was compared by the Student-Newman-Keuls (SNK) test. Pronounced reduction ( P < 0.001 ) of cholesterol in overt as compared to control and subclinical was noticed, whereas marked improvement ( P < 0.001 ) was evidenced in follow-up. Prominent elevation ( P < 0.05 ) of TG in follow-up was evidenced as compared to control. Overt presented marked reduction of HDL-C as compared to subclinical and control ( P < 0.01 and P < 0.001 ), respectively. Pronounced elevation ( P < 0.001 ) of HDL-C was evidenced after treatment. Overt presented reduction of LDL-C as compared to subclinical and control ( P < 0.01 and P < 0.05 , respectively). The follow-up group demonstrated considerable ( P < 0.001 ) improvement of LDL-C after treatment and elevation ( P < 0.05 ) as compared to control. Overt presented reduction of Apo-B as compared to subclinical and control ( P < 0.05 and P < 0.001 , respectively). Improvement ( P < 0.05 ) of Apo-B was evidenced in follow-up. Reduction ( P < 0.05 ) of Apo-A in overt as compared to control and elevation ( P < 0.05 ) in follow-up as compared to overt was evidenced. Conclusively, improvement after treatment was evidenced in lipid profile.

Studying the Association Between Systolic Blood Pressure and Thyroid Stimulating Hormone in Newly Diagnosed Subclinical Hyperthyroidism Female Patients

“…From Tables 1 and 2, there was not any significant change in lipid profile parameters and systolic and diastolic blood pressure in both subclinical hyperthyroidism and control groups. Our results are in agreement with those of Heemstra et al, Iqbal et al, Maratou et al (Heemstra et al, 2006;Iqbal et al, 2021;Maratou et al, 2010). Thyroid hormones participate in lipid biosynthesis and degradation.…”

“…Thyroid hormones participate in lipid biosynthesis and degradation. But the degradation process exceeds the biosynthesis this is why serum total cholesterol and triglyceride decreased insignificantly in the subclinical hyperthyroid group (Iqbal et al, 2021). As expected, there is a state of hypermetabolism in patients with subclinical hyperthyroidism similar to those with overt hyperthyroidism (Soni and Kaushik, 2014).…”

Elevated Free Thyroxine Levels Might Alter the Effect of the Lipid Profile on Insulin Resistance in Type 2 Diabetes Mellitus

“…Previous research has shown that low TSH levels do cause an increase in TG and LDL cholesterol levels and a decrease in HDL cholesterol levels, [ 14 ] and that elevated FT4 levels do indeed increase TG and decrease HDL cholesterol levels in patients with hyperthyroidism [ 15 ]. These findings may be explained by the fact that FT4 increases intestinal glucose absorption, decreases insulin secretion, increases liver glucose production, and increases catecholamines, leading to insulin resistance [ 16 , 17 , 18 ].…”

Corrigendum to “Prospective Analysis of Lipid Variations in Hyperthyroid Subjects from Lahore, Pakistan”

“…In the article titled “Prospective Analysis of Lipid Variations in Hyperthyroid Subjects from Lahore, Pakistan” [ 1 ], the authors have identified minor errors in Figure 1 and Table 1 . The corrected Figure 1 and Table 1 are as follows:…”