Prospective evaluation of psychological burden in patients with oral cancer

Kumar, Kapila; Kumar, Sumit; Mehrotra, Divya; Tiwari, Sunita; Kumar, Vijay; Khandpur, Sukhanshi; Dwivedi, Raghav C.

doi:10.1016/j.bjoms.2018.09.004

Cited by 24 publications

(18 citation statements)

References 23 publications

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“…The prevalence of depressive symptoms in the study was 65.21%, which was similar with the results in previous studies among cancer patients [9], and higher than a meta-analysis on the prevalence of depression in Chinese adults with cancer patients (54.9%) [8]. A recent research among patients with oral cancer [44] also confirmed the similar findings at different time points (at diagnosis, 1 month, and 3 months after treatment). This phenomenon is particularly obvious in patients with oral cancer due to facial deformity and dysfunction, and can be explained as the assumption that anxiety is likely to be caused by the on-thespot sense of uncertainty, while depression by losing hope for the future and meaning of life.…”

Section: Discussionsupporting

confidence: 90%

Prevalence and predictors of anxiety and depressive symptoms among patients diagnosed with oral cancer in China: a cross-sectional study

et al. 2020

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Background: Anxiety and depression are common mental health problems among patients with cancer. While many psychological variables have been proven to influence anxiety and depressive symptoms, the variables are not mutually exclusive and their integrated effects on patients with oral cancer are yet unknown. The present study aims to explore the prevalence of anxiety and depressive symptoms among patients with oral cancer, to find out key potentially predictive factors associated with anxiety and depressive symptoms. Method: A cross-sectional study was carried out for Chinese patients with oral cancer between May 2016 and October 2017 in two Grade-A Tertiary Hospitals in Shenyang, China. Two hundred thirty patients with oral cancer were interviewed with questionnaires on demographic variables, Zung Self-Rating Anxiety Scale (SAS), Center for Epidemiologic Studies Depression Scale (CES-D), Herth Hope Index (HHI), Social Impact Scale, Multidimensional Scale of Perceived Social Support (MSPSS), Revised Life Orientation Test (LOT-R), Perceived Stress Scale-10 (PSS-10), and General Perceived Self-efficacy Scale(GSE). Chi-square test, nonparametric test, t-test and logistic regression analyses were conducted where appropriate to explore predictive factors of anxiety symptoms and depressive symptoms. Results: The prevalence of anxiety symptoms and depressive symptoms in the sample population was 36.96% (85/230) and 65.21% (150/230), respectively. Social isolation dimension of stigma (β = 0.436, OR = 1.547, CI:1.211~1.975), optimism (β = − 0.276, OR = 0.759, CI:0.624~0.922), and perceived stress (β = 0.217, OR = 1.243, CI:1.092~1.414) were predictors of anxiety symptoms. Marriage (β = 1.648, OR = 5.198, CI:1.427~18.924), positive readiness and expectancy dimension of hope (β = − 0.505, OR = 0.604, CI:0.395~0.923), social isolation dimension of stigma (β = 0.314, OR = 1.368, CI:1.054~1.776) and perceived stress (β = 0.273, OR = 1.314, CI:1.134~1.524) were predictors of depressive symptoms among oral cancer patients. Conclusion: The prevalence of anxiety symptoms and depressive symptoms was high among oral cancer patients in China. The communal predictors of anxiety and depressive symptoms in patients with oral cancer were levels of perceived stress and social isolation of stigma. In addition, optimism was a predictor of anxiety symptoms and hope was a predictor of depressive symptoms.

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Section: Discussionsupporting

confidence: 90%

Prevalence and predictors of anxiety and depressive symptoms among patients diagnosed with oral cancer in China: a cross-sectional study

et al. 2020

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“…The prevalence of depressive symptoms in the study was 65.21%, which was similar with the results in previous studies among cancer patients [9], and higher than a meta-analysis on the prevalence of depression in Chinese adults with cancer patients (54.9%) [8]. A recent research among patients with oral cancer [43] also confirmed the similar findings at different time points (at diagnosis, one month, and three months after treatment). This phenomenon is particularly obvious in patients with oral cancer due to facial deformity and dysfunction, and can be explained as the assumption that anxiety is likely to be caused by the on-the-spot sense of uncertainty, while depression by losing hope for the future and meaning of life.…”

Section: Discussionsupporting

confidence: 90%

Prevalence and Predictors of Anxiety and Depressive Symptoms among Patients Diagnosed with Oral Cancer in China: A cross-sectional study

Yuan

Pan

Wang

et al. 2020

Preprint

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Background Anxiety and depression are common mental health problems among patients with cancer. While many psychological variables have been proven to influence anxiety and depressive symptoms, the variables are not mutually exclusive and their integrated effects on patients with oral cancer are yet unknown. The present study aims to explore the prevalence of anxiety and depressive symptoms among patients with oral cancer, to find out key potentially predictive factors associated with anxiety and depressive symptoms. Method A cross-sectional study was carried out for Chinese patients with oral cancer between May 2016 and October 2017 in two Grade-A Tertiary Hospitals in Shenyang, China. 230 patients with oral cancer were interviewed with questionnaires on demographic variables, Zung Self-Rating Anxiety Scale (SAS), Center for Epidemiologic Studies Depression Scale (CES-D), Herth Hope Index (HHI), Social Impact Scale, Multidimensional Scale of Perceived Social Support (MSPSS), Revised Life Orientation Test (LOT-R), Perceived Stress Scale-10 (PSS-10), and General Perceived Self-efficacy Scale(GSE). Chi-square test, nonparametric test, t-test and logistic regression analyses were conducted where appropriate to explore predictive factors of anxiety symptoms and depressive symptoms. Result The prevalence of anxiety symptoms and depressive symptoms in the sample population was 36.96% (85/230) and 65.21% (150/230), respectively. Social isolation dimension of stigma (β=0.436, OR=1.547, CI:1.211~1.975), optimism (β=-0.276, OR=0.759, CI:0.624~0.922), and perceived stress (β=0.217, OR=1.243, CI:1.092~1.414) were predictors of anxiety symptoms. Marriage (β=1.648, OR=5.198, CI:1.427~18.924), positive readiness and expectancy dimension of hope (β=-0.505, OR=0.604, CI:0.395~0.923), social isolation dimension of stigma (β=0.314, OR=1.368, CI:1.054~1.776) and perceived stress (β=0.273, OR=1.314, CI:1.134~1.524) were predictors of depressive symptoms among oral cancer patients. Conclusion The prevalence of anxiety symptoms and depressive symptoms was high among oral cancer patients in China. The communal predictors of anxiety and depressive symptoms in patients with oral cancer were levels of perceived stress and social isolation of stigma. In addition, optimism was a predictor of anxiety symptoms and hope was a predictor of depressive symptoms.

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“…Up to 2021, only one systemic review 21 study that link oral cavity cancer as a risk factor for depression with varied severity of symptoms after cancer treatment. Among the previous studies, Jansen et al (2018) 22 and Kuma et al (2018) 23 , using validated questionnaires, found that oral cancer is associated with the risk of depression. In addition, Rana et al (2015) 24 have compared the risk of depression in the patients with oral squamous cell carcinoma and oral lichen planus.…”

Section: Introductionmentioning

confidence: 99%

Risk of depression in patients with oral cancer: a nationwide cohort study in Taiwan

Kung

Chung

et al. 2021

Sci Rep

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This study investigates an association between oral cancers and the risk of developing depression. We conducted a total of 3031 patients with newly diagnosed oral cancers and 9093 age-, sex-, and index year-matched controls (1:3) from 2000 to 2013 were selected from the National Health Insurance Research Database (NHIRD) of Taiwan. After adjusting for confounding factors, multivariate Cox proportional hazards analysis was used to compare the risk of depression over a 13-year follow-up. Of the patients with oral cancer, 69 (2.28%, or 288.57 per 105 person-years) developed depression compared to 150 (1.65%, 135.64 per 105 person-years) in the control group. The Cox proportional hazards regression analysis showed that the adjustment hazard ratio (HR) for subsequent depression in patients with oral cancer diagnosed was 2.224 (95% Confidence Interval [CI] 1.641–3.013, p < 0.001). It is noteworthy that in the sensitivity analysis is the adjusted HR in the group with depression diagnosis was 3.392 and in the oral cancer subgroup of “Tongue” was 2.539. This study shows oral cancer was associated with a significantly increased risk for developing subsequent depression and early identification and treatment of depression in oral cancer patients is crucial.

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Prospective evaluation of psychological burden in patients with oral cancer

Cited by 24 publications

References 23 publications

Prevalence and predictors of anxiety and depressive symptoms among patients diagnosed with oral cancer in China: a cross-sectional study

Prevalence and predictors of anxiety and depressive symptoms among patients diagnosed with oral cancer in China: a cross-sectional study

Prevalence and Predictors of Anxiety and Depressive Symptoms among Patients Diagnosed with Oral Cancer in China: A cross-sectional study

Risk of depression in patients with oral cancer: a nationwide cohort study in Taiwan

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