Prospective Inverse Associations of Sex Hormone Concentrations in Men With Biomarkers of Inflammation and Oxidative Stress

Häring, R.; Baumeister, Sebastian E.; Völzke, Henry; Dörr, Marcus; Köcher, Thomas; Nauck, Matthias; Wallaschofski, Henri

doi:10.2164/jandrol.111.015065

Cited by 51 publications

(42 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study revealed that AMS values were significantly positively correlated with FBG levels, fasting pressed by testosterone administration in hypogonadotropic men have been reported [28]. Haring et al demonstrated inverse associations between sex hormone concentrations and proinflammatory and oxidative stress markers [29]. In addition, Bobjer J et al reported that even subnormal testosterone levels at a young age may already associate with low-grade inflammation [30].…”

Section: Discussionsupporting

confidence: 58%

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

et al. 2017

View full text Add to dashboard Cite

DECREASED ANDROGEN LEVELS associated with aging cause various symptoms, termed late-onset hypogonadism (LOH) [1][2][3]. LOH is characterized by (i) somatovegetative symptoms and conditions, including weakness, fatigue, sleep disturbance, visceral obesity, sarcopenia and osteopenia (or osteoporosis), (ii) psychological symptoms, including disturbed sense of well-being, depressed mood, irritability and anxiety and (iii) sexual symptoms, including decreased libido and erectile dysfunction.Visceral obesity has been proposed to be caused by vice circulation. Specifically, decreased androgen lev-A higher score on the Aging Males' Symptoms scale is associated with insulin resistance in middle-aged men Abstract. An age-associated androgen decrease and its pathological conditions are defined as late-onset hypogonadism (LOH). Among the various symptoms associated with LOH, a visceral fat increase is strongly associated with relatively low levels of testosterone. However, few studies have investigated the relationship between the Aging Males' Symptoms (AMS) scores and metabolic abnormalities. Thus, we aimed to clarify this relationship by investigating the relationship between AMS scores and various markers in blood. During routine health examinations in 241 middle-aged males (52.7±7.5 years of age, mean±SD), 150 males (62.2%) displayed higher AMS values than normal. No statistical association was observed between total AMS scores and any testosterone value. All mental, physical and sexual AMS subscales were significantly positively correlated with insulin levels and HOMA-IR. Only sexual subscale scores were significantly inversely associated with free or bioavailable testosterone level. Males with insulin resistance (HOMA-IR≥2.5) demonstrated significantly higher AMS scores than those with normal insulin sensitivity (HOMA-IR<2.5). AMS values were positively correlated with fasting blood glucose, insulin and HOMA-IR values. Interestingly, univariate and multivariate analyses revealed that HOMA-IR≥2.5 was a significant predictor for detection of moderately severe AMS values (AMS≥37), whereas AMS≥37 was not a predictor of metabolic syndrome by International Diabetes Federation (IDF) criterion. In conclusion, almost 60% of healthy male subjects displayed abnormal AMS scores. AMS values were not associated with testosterone values but rather were related to insulin resistance, particularly in subjects with moderately severe AMS values. Insulin resistance-related general unwellness might be reflected by AMS values.Key words: Testosterone, Late-onset hypogonadism, Insulin resistance, Metabolic syndrome els result in visceral obesity, which then leads to the suppression of gonadotropin and subsequent testosterone deficiency [4]. We have reported that male ARKO mice develop visceral obesity because of decreased energy expenditure [5]. Metabolic syndrome (MetS) is characterized by multiple cardiovascular risk complications, including visceral obesity, hypertension, glucose tolerance and dyslipidemia. MetS incidence is rapidly incre...

show abstract

Section: Discussionsupporting

confidence: 58%

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Together, these results suggest that a certain amount of testosterone is essential for BPI expression, and high levels of testosterone may increase BPI expression in the epididymis. In fact, it has been reported that a number of proteins in the testis and epididymis involved in sperm maturation and fertilization, such as glutathione peroxidase (Klapcinska et al 2008) and g-glutamyl transferase (Haring et al 2012), are regulated by testosterone and play a role in reproductive activities. Therefore, the regulation of BPI expression by testosterone suggests that BPI may play a crucial role in fertilization.…”

Section: Discussionmentioning

confidence: 99%

Bactericidal/permeability-increasing protein in the reproductive system of male mice may be involved in the sperm–oocyte fusion

Li¹,

Liu²,

Xia³

et al. 2013

Reproduction

View full text Add to dashboard Cite

Bactericidal/permeability-increasing protein (BPI) is a 455-residue (w55 kDa) protein found mainly in the primary (azurophilic) granules of human neutrophils. BPI is an endogenous antibiotic protein that belongs to the family of mammalian lipopolysaccharide (LPS)-binding and lipid transport proteins. Its major function is to kill Gram-negative bacteria, thereby protecting the host from infection. In addition, BPI can inhibit angiogenesis, suppress LPS-mediated platelet activation, increase DNA synthesis, and activate ERK/Akt signaling. In this study, we found that Bpi was expressed in the testis and epididymis but not in the seminal vesicles, prostate, and solidification glands. BPI expression in the epididymis increased upon upregulation of testosterone, caused by injection of GNRH. In orchidectomized mice, BPI expression was significantly reduced, but its expression was restored to 30% of control levels in orchidectomized mice that received supplementary testosterone. The number of sperm fused per egg significantly decreased after incubation with anti-BPI antiserum. These results suggest that BPI may take part in the process of sperm-oocyte fusion and play a unique and significant role in reproduction.

show abstract

“…It is known that activity of GGT depends on menopause in women [9]. Furthermore, testosterone, human sex hormone-binding globulin and dehydroepiandrosterone are inversely associated with the change in GGT [10]. Pei et al [11] found that GGT is the most suitable parameter among liver function tests for the prediction of metabolic syndrome but only in men.…”

Section: Omówieniementioning

confidence: 99%

“…Potwierdzono, że aktywność GGT u kobiet ma związek z menopauzą [9]. Z kolei testosteron, ludzkie białko wiążące hormony płciowe oraz dehydroepiandrosteron wykazują odwrotną zależność ze zmianami aktywności GGT [10]. Pei i wsp.…”

Section: Omówienieunclassified

Parameters of liver function in patients with psoriasis vulgaris

Oszukowska¹,

Kręgiel²,

Kaczmarek³

et al. 2017

View full text Add to dashboard Cite

Introduction. Patients with psoriasis develop nonalcoholic fatty liver disease more often than healthy subjects. Objective. To estimate the level of basic parameters of liver function, compare these values between groups of patients with psoriasis and healthy individuals, and refer these values to selected risk factors of developing atherosclerosis. Material and methods. A case-control study in the dermatology department included 66 patients with psoriasis and 30 healthy volunteers. The two groups were comparable as regards age, sex and body mass index as well as abdominal circumference. In all subjects we estimated the parameters of liver function and selected the risk factors of atherosclerosis. Results. γ-Glutamyltransferase activity in patients with psoriasis was significantly higher than in the reference group individuals (p = 0.002) and it applies to men only (p = 0.0003). In women γ-glutamyltransferase activity was higher in patients with positive family history of psoriasis (p = 0.03). γ-Glutamyltransferase activity was also higher in smoking patients (p = 0.02). Activity and concentration of other liver function markers (alanine aminotransferase, aspartate aminotransferase, and bilirubin) did not differ significantly between healthy individuals and patients with psoriasis. There were no differences between patients with severe, moderate and mild psoriasis. A negative correlation between bilirubin concentration and age of patients (p = 0.02) and bilirubin and C-reactive protein concentration (p = 0.03) was observed. Activity of alanine aminotransferase correlated positively with abdominal circumference (p = 0.001), uric acid concentration (p = 0.004) and body mass index (p = 0.001). Activity of aspartate aminotransferase correlated positively with abdominal circumference (p = 0.001), uric acid concentration (p = 0.03) and body mass index (p = 0.001). Additionally, the increase in alanine aminotransferase activity was proportional to the increase in cholesterol (p = 0.01) and apolipoprotein B concentrations (p = 0.03). γ-Glutamyltransferase activity correlated positively with the concentration of uric acid (p = 0.008), cholesterol (p = 0.04), triglycerides (p = 0.04), and apolipoprotein B (p = 0.03). Conclusions. In patients with psoriasis increased activity of alanine aminotransferase and aspartate aminotransferase parameters probably result from liver diseases since they accompany dyslipidemia and obesity whereas the increase of γ-glutamyltransferase activity is probably associated mainly with psoriasis.

show abstract

Prospective Inverse Associations of Sex Hormone Concentrations in Men With Biomarkers of Inflammation and Oxidative Stress

Cited by 51 publications

References 51 publications

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

Bactericidal/permeability-increasing protein in the reproductive system of male mice may be involved in the sperm–oocyte fusion

Parameters of liver function in patients with psoriasis vulgaris

Contact Info

Product

Resources

About

Prospective Inverse Associations of Sex Hormone Concentrations in Men With Biomarkers of Inflammation and Oxidative Stress

Cited by 51 publications

References 51 publications

A higher score on the Aging Males&rsquo; Symptoms scale is associated with insulin resistance in middle-aged men

A higher score on the Aging Males&rsquo; Symptoms scale is associated with insulin resistance in middle-aged men

Bactericidal/permeability-increasing protein in the reproductive system of male mice may be involved in the sperm–oocyte fusion

Parameters of liver function in patients with psoriasis vulgaris

Contact Info

Product

Resources

About

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men