Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism

Verkauskas, Gilvydas; Malcius, Dalius; Eidukaitė, Audronė; Vilimas, Juozas; Dasevičius, Darius; Bilius, Vytautas; Hadžiselimović, Faruk

doi:10.1016/j.jpurol.2016.05.007

Cited by 32 publications

(40 citation statements)

References 26 publications

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“…4 B). In this study, inhibin B was not associated with Ad/T, which is in accordance with a study of Verkauskas et al [2016], who included cryptorchid boys at the age of 7-65 months. However, our previous research in cryptorchid boys aged 0.5-13 years [Cortes et al, 2016] revealed a significant correlation between Ad/T and inhibin B.…”

Section: Discussionsupporting

confidence: 90%

Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

Hildorf¹,

Dong²,

Thorup³

et al. 2019

Sex Dev

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Postnatal maturation of Sertoli cells is crucial for male fertility. The aim of this study was to assess the association between the Sertoli cell number per tubule cross-section (SC/T), the serum level of the Sertoli cell-produced inhibin B, and the A-dark spermatogonia number per tubule (Ad/T) in cryptorchid boys. Forty infant cryptorchid boys aged 4-35 months (median: 13 months) were included in the study. During orchiopexy, blood samples for serum inhibin B, luteinizing hormone (LH), and follicle stimulating hormone (FSH) and testicular biopsies were obtained. Histological sections were evaluated by quantitative immunohistochemical and immunofluorescence analysis including VASA and SOX9 (Sertoli cell marker) in order to measure the tubular germ cell number (G/T), Ad/T, and SC/T. The SC/T correlated negatively with age (p < 0.0002) and positively with G/T, Ad/T, inhibin B, FSH, and LH (all p < 0.01). Inhibin B correlated with LH (p < 0.0001), but not with FSH (p = 0.2077). The SC/T:G/T ratio positively correlated with age (p < 0.0001). Boys with Ad spermatogonia at surgery had a higher number of Sertoli cells compared to boys without Ad spermatogonia. In conclusion, a correlation between Sertoli cell number and inhibin B was proven, indicating that inhibin B possibly reflects the function of Sertoli cells in infant cryptorchid boys.

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Section: Discussionsupporting

confidence: 90%

Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

Hildorf¹,

Dong²,

Thorup³

et al. 2019

Sex Dev

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“…Studies and investigations since the 1920s have shown that the descensus of the testicles is essential for the production of viable and mature spermatozoa (Raman & Schlegel, ). Despite surgical correction in early childhood, bilateral cryptorchidism may result in azoospermia, because bilaterality is a risk factor for a negative prognosis (Verkauskas et al, ). Early orchidopexy is the preferred treatment option for this fertility risk factor (Chiba et al, ).…”

Section: Discussionmentioning

confidence: 99%

Are predictive factors in sperm retrieval and pregnancy rates present in nonobstructive azoospermia patients by microdissection testicular sperm extraction on testicle with a history of orchidopexy operation?

Ozan

Karakeçi

Kaplancan³

et al. 2019

Andrologia

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The aim in this study is to evaluate predictive factors on sperm retrieval and pregnancy rates by microdissection testicular sperm extraction in non obstructive azoospermia patients with a history of orchidopexy operation. A total of 148 patients were included, and their medical files were evaluated. Data related to possible predictive factors on sperm retrieval and pregnancy rates such as age at orchidopexy operation, unilateral or bilateral presence of undescended testis before orchidopexy, testis volumes and hormone levels were statistically analysed. It revealed that the mean ages in patients with unilateral and bilateral orchidopexy operations were 35.37 (±4.84) and 33.94 (±5.91) respectively. Mean testis volume in the unilateral orchidopexy group was 7.59 (±3.12) ml on the right testis and 7.37 (±2.86) ml on the left testis. Mean FSH levels were detected as 22.71 (±11.86) mIU/ml in the unilateral group and 28.19 (±12.40) mIU/ml in the bilateral group. In our study, we have shown that the age at which patients undergo orchidopexy and the unilateral or bilateral presence of cryptorchidism has no correlation with sperm retrieval and pregnancy rates.

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“…Kuijper et al [26] studied testicular volumes in 344 children between 0-6 years old using US and showed differences in mean testicular volume according to minipuberty in the first year of life. They also found that mean testicular volume increased from 0.27 cc to 0.44 cc in the first five months of life, followed by a decrease, and ultimately stabilizing at 0.31 cc.…”

Section: Discussionmentioning

confidence: 99%

Testicular volume and elasticity changes in young children with undescended testes

et al. 2017

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Aims: To evaluate the differences and changes of testicular volume and elasticity in normal (NL) testes and undescended testes (UDTs) of children using shear wave elastography (SWE).Materials and methods: Testicular ultrasound images from children younger than 60 months old were retrospectively reviewed. Testicular volumes and elasticities were compared between the UDT group and NL group. In patients with unilateral UDT (uUDT), we also compared the values between uUDT and contralateral grossly normal (CGN) testis groups.Results: There were 25 UDTs including 4 bilateral in the UDT groupand 54 normal testes in the NL group. While testicular volume was significantly smaller in UDT (vs. NL) and uUDT (vs. CGN) groups, the elasticity was not different. Testicular volume was positively correlated with age in both NL (r=0.474) and CGN (r=0.729) groups (p<0.001), while there was no correlation in the UDT group. Testicular stiffness showed negative correlation with age in the NL group (r=-0.390, p=0.004) and positive correlation in the UDT group (r=0.426, p=0.034).Conclusions: Instead of increasing volume and decreasing stiffness of normal testes during development of the early 60 months, UDTsexhibited smaller volume and increasing stiffness. The CGN testes of uUDT patients showed increasing volume without stiffness change.

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Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism

Cited by 32 publications

References 26 publications

Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

Are predictive factors in sperm retrieval and pregnancy rates present in nonobstructive azoospermia patients by microdissection testicular sperm extraction on testicle with a history of orchidopexy operation?

Testicular volume and elasticity changes in young children with undescended testes

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