Prospects of application of drugs based on guaric acid in treatment of patients with osteoarthritis and comorbid course of steatohepatitis and excessive body weight

Abstract

One of the factors of osteoarthritis is obesity, which is now considered to be one of the major health problems around the world. Patients with osteoarthritis have a high comorbidity index. Medicamental therapy of patients with osteoarthritis and comorbid course of steatohepatitis is associated with additional risks such as hepatotoxic effects of drugs that patients take. Purpose: to review scientific articles which cover information on effectiveness of using drugs based on guaric acid to reduce excess body weight. Conclusion. Increased accumulation of visceral adipose tissue is one of the main pathogenetic factors contributing to development of osteoarthritis, steatosis and steatohepatitis. Therefore, drugs aimed at reducing excess body weight should take a leading place in the complex therapy of patients. Such drugs can contribute to reducing early disability of population, optimizing the quality of life indicators, and total life expectancy.