Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

Jeong, Kwan; Jung, Jin Seung; Kim, Jung Eun; Kang, Hoon

doi:10.3390/ijms19020556

Cited by 19 publications

(16 citation statements)

References 36 publications

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“…PGD2 was found to activate androgen receptors in the human dermal papilla cells (hDPC) via the protein kinase B (AKT) pathways leading to the release of multiple cytokines that induce follicular apoptosis 16 . Moreover, PGD2 through its effects on G protein–coupled receptor 44 (GR44) found in the outer root sheath of hair follicles and dermal papillae was found to inhibit hair growth cycles and lead to miniaturization of hair follicles 17 .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case‐controlled study

Zaky

Khodeir

Ahmed

et al. 2021

J of Cosmetic Dermatology

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Background Androgenetic alopecia (AGA) is the most common form of alopecia in men. Cetirizine, a second‐generation H1 blocker, is known for its anti‐inflammatory properties and its ability to decrease prostaglandin D2 (PGD2) production. Aim To evaluate the efficacy and tolerability of topical cetirizine in male patients with AGA. Methods Two groups of 30 patients each (healthy males aged between 22 and 55 years) with different grades of AGA classified according to the Hamilton‐Norwood classification were recruited for this study. Group A subjects applied 1 mL of 1% topical cetirizine daily, while group B subjects served as controls and were instructed to apply 1 mL of a placebo solution for 6 months. Results Dermoscopic assessment revealed significantly higher hair regrowth among the cetirizine‐treated group (P < .001). The patients’ satisfaction was significantly higher among the cetirizine‐treated group (P < .001). Conclusion The current study highlights a potential role cetirizine might have in treating AGA. It should be noted that studies are lacking in this regard and more randomized and controlled trials are warranted in order to confirm or refute such early findings.

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Section: Discussionmentioning

confidence: 99%

Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case‐controlled study

Zaky

Khodeir

Ahmed

et al. 2021

J of Cosmetic Dermatology

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“…Furthermore, hair folicles are a source of pro-angiogenic factors, such as VEGF 52 . Few studies have investigated the effects of fatty acids on skin hair growth 53,54 .…”

Section: Discussionmentioning

confidence: 99%

Oral administration of EPA-rich oil impairs collagen reorganization due to elevated production of IL-10 during skin wound healing in mice

Bürger

Kühl

Candreva

et al. 2019

Sci Rep

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Wound healing is an essential process for organism survival. Some fatty acids have been described as modulators of wound healing. However, the role of omega-3 fatty acids is unclear. In the present work, we investigate the effects of oral administration of eicosapentaenoic acid (EPA)-rich oil on wound healing in mice. After 4 weeks of EPA-rich oil supplementation (2 g/kg of body weight), mice had increased serum concentrations of EPA (20:5ω-3) (6-fold) and docosahexaenoic acid (DHA; 22:6ω-3) (33%) in relation to control mice. Omega-3 fatty acids were also incorporated into skin in the EPA fed mice. The wound healing process was delayed at the 3 rd and 7 th days after wounding in mice that received EPA-rich oil when compared to control mice but there was no effect on the total time required for wound closure. Collagen reorganization, that impacts the quality of the wound tissue, was impaired after EPA-rich oil supplementation. These effects were associated with an increase of M2 macrophages (twice in relation to control animals) and interleukin-10 (IL-10) concentrations in tissue in the initial stages of wound healing. In the absence of IL-10 (IL-10 −/− mice), wound closure and organization of collagen were normalized even when EPA was fed, supporting that the deleterious effects of EPA-rich oil supplementation were due to the excessive production of IL-10. In conclusion, oral administration of EPA-rich oil impairs the quality of wound healing without affecting the wound closure time likely due to an elevation of the anti-inflammatory cytokine IL-10.

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“…Peptides and some growth factors have also shown inhibitory effects on DPCs. In addition, certain other agents have exerted inhibition of DPCs activity in vitro .…”

Section: Hair Growth Inhibitory Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

127

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

Cited by 19 publications

References 36 publications

Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case‐controlled study

Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case‐controlled study

Oral administration of EPA-rich oil impairs collagen reorganization due to elevated production of IL-10 during skin wound healing in mice

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

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