Prostate cancer and human papillomavirus infection: a recent literature review

Mahmoudi, Samira; Jafari-Sales, Abolfazl; Nasiri, Rozita; Baghi, Hossein Bannazadeh

doi:10.1097/mrm.0000000000000261

Cited by 4 publications

(3 citation statements)

References 96 publications

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“…In this study, one patient in the younger subgroup was infected by HPV, but six patients in the elder subgroup were HPV infected. Elderly patients may have a weaker immune system, making them more susceptible to HPV, and further heightened the risk for PCa [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

A non-socially-sensitive predictive model of prostate cancer for Asian males with benign prostatic hyperplasia: A multi-site cross-sectional case-control study

Chang,

Moi,

Chan

et al. 2023

PLoS ONE

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Background Benign prostatic hyperplasia (BPH) is common in aging Asian males and is associated with an excess risk of developing prostate cancer (PCa). However, discussions about socially-sensitive experiences such as sexual activity, which can significantly predict PCa risk, may be considered stigmatized in Asian culture. This study aimed to develop a predictive model for PCa risk in Asian males with BPH using non-socially-sensitive information. Methods A cross-sectional case-control study, with PCa patients as the cases and remaining as the controls, was conducted on a cohort of Taiwanese males with BPH from four medical institutions. Patients who met the inclusion criteria were enrolled, excluding those aged over 86 years or who had received human papillomavirus (HPV) vaccination. Non-socially-sensitive variables such as obesity, occupational exposure, HPV infection, and PCa family history score (FH score) were included in a fully adjusted logistic regression model, and depicted using a nomogram. Results Among 236 BPH patients, 45.3% had PCa. Obesity, occupational exposure, HPV infection, and family history of PCa were significantly associated with PCa risk. The FH score (OR = 1.89, 95% CI = 1.03–3.47, P = 0.041) had the highest impact, followed by HPV infection (OR = 1.47, 95% CI = 1.03–2.11, P = 0.034), occupational exposure (OR = 1.32, 95% CI = 1.15–1.51, P <0.001), and obesity (OR = 1.22, 95% CI = 1.07–1.41, P = 0.005). The nomogram accurately depicted the predictive risk, and the model demonstrated robust performance compared to individual factors. In addition, the subgroup analysis results showed elderly age group could obtain more favorable predictive performance in our proposed model (AUC = 0.712). Conclusion This non-socially-sensitive predictive model for PCa risk in Taiwanese males with BPH integrates multiple factors that could provide acceptable PCa risk-predictive performance, especially for elderly BPH patients over 70 years, aiding clinical decision-making and early cancer detection.

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Section: Discussionmentioning

confidence: 99%

A non-socially-sensitive predictive model of prostate cancer for Asian males with benign prostatic hyperplasia: A multi-site cross-sectional case-control study

Chang,

Moi,

Chan

et al. 2023

PLoS ONE

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“…It has been shown that the prostate might be a target for HPV infections because of its anatomical location [7]. Even though HPV gene sequences were found in most usual, benign, and malignant prostate tissues [8,9], HPV infection possibly modulates the behavior of PCa cells via affecting apoptosis mechanisms, anoikis, anti-tumor immunity suppression, and resistance mechanisms, which results in metastasis [10]. However, the potential role of HR-HPV infection in PCa development has not yet been established [11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Oncogene Proteins of Human Papillomaviruses on Apoptosis Pathways in Prostate Cancer

Baladehi¹,

Memar²,

Jafari-Sales³

et al. 2022

Oncologie

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The ability of host cells to activate apoptosis is perhaps the most potent weapon for helping cells eliminate viruses. Human papillomaviruses (HPV) activate several pathways, enabling the infected cells to avoid extrinsic and intrinsic apoptosis pathways. The incapacity of prostatic epithelial cells to induce apoptosis leads to the invasive development of prostate cancer. For the pathogenesis of prostate cancer, several risk factors have been reported; for example, some viruses and infectious diseases have been proposed as causative agents for their relation to prostate diseases. According to several studies, high-risk human papillomaviruses cause malignancy by interfering with the apoptotic and inflammatory pathways; these viruses, such as HPV16 and HPV18, block apoptotic pathways and result in prostate cancer. This review is dedicated to presenting a summary of oncogenes (E5, E6, and E7) HR-HPVs' functions on signaling pathways, inflammation in prostate tumorigenesis, and emphasizing the link between these oncogenes with apoptosis and prostate cancer.

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“…HPVs can be classified into low-risk (6,18,31,33,34,35,39,45,51,52,56,58,59, 66, 68, and 70) and high-risk (6, 11, 42, 43, and 44) HPV types based on their association with cervical cancer [12]. HPV gene sequences are in most prostate tissues, including normal, benign, and malignant specimens [3,5,13,15]. In high-risk HPV types, E5, E6, and E7 proteins overlap with tumor-suppressor proteins in cells.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran

Baladehi

Bazmani²,

Oskouee³

et al. 2022

J Inflamm Dis

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Background: Prostate cancer (PCa), as the fifth leading cause of death, is the second most common cancer diagnosis in men worldwide. Human papillomavirus (HPV) can potentially contribute to PCa development and chronic inflammation. HPV infection leads to malignant and benign lesions in the genital areas of men and women. The data on the role of HPV in PCa development is contradictory. Objective: This study aims to investigate the frequency of HPV in PCa samples in hospitals in Tabriz City, Iran. Methods: This study was conducted in a cross-sectional descriptive manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the polymerase chain reaction (PCR) method. Findings: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, no connection exists between HPV and PCa. The Mean±SD age of HPV positive samples was 61.33±11.50 years. Conclusion: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.

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Prostate cancer and human papillomavirus infection: a recent literature review

Cited by 4 publications

References 96 publications

A non-socially-sensitive predictive model of prostate cancer for Asian males with benign prostatic hyperplasia: A multi-site cross-sectional case-control study

A non-socially-sensitive predictive model of prostate cancer for Asian males with benign prostatic hyperplasia: A multi-site cross-sectional case-control study

The Effect of Oncogene Proteins of Human Papillomaviruses on Apoptosis Pathways in Prostate Cancer

Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran

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