Prostate Cancer: Comparison of Dynamic Contrast-Enhanced MRI Techniques for Localization of Peripheral Zone Tumor

Abstract

For the experienced reader, sensitivity for peripheral zone tumor was increased by use of either a semiquantitative or quantitative model compared with a qualitative model and decreased by requiring washout. We failed to identify a difference in performance between semiquantitative and quantitative models.

Prostat Kanseri Tani ve Yonetiminde Dinamik Kontrastli MRG

“…Rosenkrantz ve ark. [15], kalitatif analiz yerine semikantitatif veya kantitatif bir yaklaşımın kullanılması ile periferal zonda tümör lokalizasyonunda duyarlılığın arttığını göstermişlerdir [12].…”

MRT der Prostata: Empfehlungen zur Vorbereitung und Durchführung

“…DCE-MRI should always be interpreted in combination with DWI and T2w imaging which is facilitated by the use of the same slice thicknesses. DCE-MRI significantly increases the accuracy of tumor detection and lesion evaluation and DCE-MRI increases the sensitivity for tumor detection particularly in the peripheral zone [29,30]. A high temporal resolution (at least 9 seconds) is a requirement for being able to measure the rapid enhancement of contrast agent in the prostate [31].…”

Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation

“…However, a high bvalue acquisition reduces the signal from normal prostatic tissue, increasing the sensitivity to abnormal cellular environments [65]. One method of gaining the advantage of contrast of a high b-value while still having the high SNR and fine resolution of a lower b-value acquisition is to extrapolate and compute the theoretical image output for higher b-values [66]. These images show higher SNR than traditional DWI collected with the equivalent high b-values and can be utilized on older 1.5T scanners where gradient hardware may not allow acquisition with high b-values [67].…”

“…There are several agents approved by the United States Food and Drug Administration, including gadopentetate dimeglumine (Magnevist), gadobutrol (Gadovist), or gadodiamide (Omniscan) [96]. Aiming for a reasonable spatiotemporal resolution, a five-minute DCE acquisition yields dynamic imaging with a temporal resolution in the range of 3-10 s, a spatial resolution in the range of 0.7 9 0.7 mm to 1.9 9 1.9 mm with a slice thickness of 3-4 mm [27,66,91,92,95,[97][98][99][100][101]. Compressed sensing techniques have been implemented into DCE sequences to improve spatiotemporal resolution or increase the coverage.…”