Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS

Barragán-Zarate, Gabriela Soledad; Lagunez-Rivera, Luicita; Solano, Rodolfo; Pineda-Peña, Elizabeth Arlen; Landa-Juárez, Arizai Yolia; Chávez-Piña, Aracely Evangelina; Carranza‐Álvarez, Candy; Hernández-Benavides, Diego Manuel

doi:10.1016/j.jep.2020.112632

Cited by 20 publications

(7 citation statements)

References 49 publications

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“…Ten grams of the powdered vegetal sample was mixed with 180 mL of solvent (mixture of ethanol/ water (50%; v/v)). Extraction was carried out at a temperature of 40°C during 20 min, with a pulse duration of 5-s on and 5-s off (Barragán-Zarate et al, 2020). Prosthechea karwinskii extract was dissolved in 0.9 % of saline solution with tween 20 for later use in the gastric damage model.…”

Section: Plant Materialsmentioning

confidence: 99%

Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat

Salinas-Nolasco

Barragán-Zarate

Lagunez-Rivera

et al. 2022

Natural Product Research

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Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that Prosthechea karwinskii leaves extract induces both an in vitro antioxidative action, and in vivo gastroprotective effect in the rat. However, the molecules involved in the gastroprotective action by Prosthechea karwinskii are not known. Thus, the aim of this study was to determine whether Prosthechea karwinskii extract modifies anti-inflammatory and antioxidative biomarkers in an in vivo rat model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and Prosthechea karwinskii leaves extract. Our results suggest that the gastroprotective effect of Prosthechea karwinskii leaves extract is related to the Embelin Benzoquinone 11.5 293.1787 C17H26O4

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Section: Plant Materialsmentioning

confidence: 99%

Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat

Salinas-Nolasco

Barragán-Zarate

Lagunez-Rivera

et al. 2022

Natural Product Research

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“…The mass spectrometer was operated in negative electrospray mode at 0.4 Bar (5.8 psi), with a mass range of 50-1000 m/z, a flow rate of 0.35 mL/min, in autoMs. The ionization of the capillary voltage (Vcap) was 2700 V [38]. Internal calibration was carried out with sodium formate.…”

Section: Identification Of Compounds By Uplc-esi-ms-qtofmentioning

confidence: 99%

Laelia furfuracea Lindl.: an Endemic Mexican Orchid with Anticoagulant Activity

et al. 2021

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Abstract. Laelia furfuracea is an endemic orchid from Mexico, with antioxidant activity. The objective of this study was to evaluate the effect of hydroethanolic extract and fractions obtained from the orchid leaves on the clotting times of patients with venous thromboembolic disease (VTD) and to identify their tentative compounds. The anticoagulant activity was evaluated by determining prothrombin (PT), thrombin (TT) and, activated partial thromboplastin (APTT) times. Identification of the compounds was carried out using a chromatographic technique with an ultra-high-performance liquid chromatographic analyzer coupled with electrospray ionization with quadrupole time of flight-mass-mass spectrometry. The extract prolonged the clotting times depending on the concentration-response (5-60 mg / mL); 25 mg/mL prolonged the PT (33.2 ± 2.3 s) and TT (33.1 ± 0.3 s); and APTT (61.8 ± 3.4 s) at a concentration of 15 mg/mL. The main groups tentatively identified were xanthine, carboxylic acid, amino acid, and phenolic compounds. These compounds or the synergy between them prolong clotting times. Laelia furfuracea is an orchid with research potential in the search for new anticoagulant agents. Resumen. Laelia furfuracea es una orquídea endémica de México, la cual posee actividad antioxidante. El objetivo de este estudio fue evaluar el efecto del extracto hidroetanólico y fracciones obtenidas de hojas de la orquídea sobre los tiempos de coagulación de pacientes con enfermedad tromboembólica venosa (ETV) e identificar sus posibles compuestos. La actividad anticoagulante se evaluó determinando los tiempos de protrombina (TP), trombina (TT) y tromboplastina parcial activada (TTPA). La identificación de los compuestos se realizó usando una técnica cromatográfica con un analizador cromatográfico líquido de Ultra Alta Resolución con Ionización por electroespray acoplado a espectrometría de masas con Cuadrupolo y Tiempo de Vuelo. El extracto prolongó los tiempos de coagulación dependiente de la concentración-respuesta (5-60 mg/mL); 25 mg/mL prolongó el TP (33.2±2.3 s) y TT (33.1±0.3 s); y TTPA (61.8±3.4 s) a una concentración de 15 mg/mL. Los principales grupos de posibles compuestos identificados fueron xantina, ácido carboxílico, aminoácido y compuestos fenólicos. Estos compuestos o la sinergia entre ellos prolongan los tiempos de coagulación. Laelia furfuracea es una orquídea con potencial en investigación para la búsqueda de nuevos agentes anticoagulantes.

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“…Inflammation is a critical pathophysiological process in many chronic diseases. The anti-inflammatory activities of numerous natural medicines have been demonstrated (Li et al, 2019;Barragan-Zarate et al, 2020). Studies have documented the anti-inflammatory functions of EL in various models, such as acute lung injury (ALI) and xylene-induced mouse models.…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Traditional Applications, Phytochemistry, and Pharmacological Activities of Eupatorium lindleyanum DC.: A Comprehensive Review

Wang

Lai

et al. 2020

Front. Pharmacol.

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Eupatorium lindleyanum DC. (EL) has a long history of traditional use in China to cure coughs, chronic bronchitis, lobar pneumonia, and hypertension. Because of this extensive use of EL in traditional medicine, this present review gives a systematic overview of the conventional applications, phytochemistry, and pharmacological effects of the herb. Literature was systematically searched using the scientific databases ScienceDirect, SciFinder, CNKI, Wiley, Baidu Scholar, SpringerLink, PubMed, Web of Science, and other professional websites. Information was also gathered from books on traditional Chinese herbal medicine, the Chinese Pharmacopoeia and Chinese Materia Medica. To date, many preparations of EL have been widely used clinically to treat various diseases of the respiratory system. More than 100 compounds have been isolated from the herb, including triterpenes, sesquiterpenes, sesquiterpene lactones, flavonoids, acyclic diterpenoids, sterols, and so on. Among them, terpenoids are considered to be the most important bioactive substances in EL. The pharmacological functions of EL, including anti-asthmatic, anti-tussive, anti-inflammatory, anti-hyperlipidemic, anti-hypertensive, anti-virus, and anti-tumor activities, have been widely investigated. However, most of the studies are preclinical research. Further studies are required to examine the underlying mechanisms of action. Traditionally, EL is used for treating many diseases, especially respiratory diseases. Unfortunately, up to now, modern studies have not yet well elucidated the conventional usage of EL. Most importantly, its biological activities and the corresponding constituents are still unclear. Moreover, studies on the pharmacokinetics and toxicity of EL are few, so data on the clinical safety of EL are lacking. Taken together, research work on EL is quite preliminary. More in-depth studies of phytochemistry, pharmacological activities, pharmacokinetics, and toxicity of the herb are needed. This review aims to provide valuable information on EL to guide future investigations and applications.

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Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS

Cited by 20 publications

References 49 publications

Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat

Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat

Laelia furfuracea Lindl.: an Endemic Mexican Orchid with Anticoagulant Activity

Traditional Applications, Phytochemistry, and Pharmacological Activities of Eupatorium lindleyanum DC.: A Comprehensive Review

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