Protecting effect of gabapentin for nausea and vomiting in the surgery of cesarean after spinal anesthesia

Memari, Fereshteh; Jadidi, Rahmatollah; Noroozi, Afsaneh; Mohammadbeigi, Abolfazl; Falahati, Jamal

doi:10.4103/0259-1162.157469

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…Inclusion criteria were including ASA I-II, 15 age of 20-35 years, patient consent, no history of cardiovascular disease (cardiac arrhythmia, ischemia and heart failure), no SSRI prescriptions, no opioid prescriptions, lack of preeclampsia and eclampsia, and no history of migraine and diabetes. 16 17 18 In addition, the exclusion criteria were including lack of patient participation, sensitivity to ondansetron and local anesthetics, contraindication for spinal anesthesia, repeated dural puncture, failed spinal anesthesia which requires adjuvants, and pre-pregnancy body mass index (BMI) less than 30. Verbal and written informed consent was obtained from all patients and the study protocol was approved by Ethical Committee of Arak University of Medical Sciences (approved number IR.ARAKMU.REC.1394.274), registered in the Iranian Registry of Clinical Trials with registration number ID: IRCT2016090629732N1.…”

Section: S Ubjects and M Ethodsmentioning

confidence: 99%

Ondansetron 8 mg and 4 mg with normal saline against post-operative headache and nausea/vomiting after spinal anesthesia: a randomized double-blind trial

et al. 2018

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The study aims to evaluate the efficacy of ondansetron in preventing post-spinal headache, considering the high prevalence of the headache in pregnant women and the common use of the adjuvants for prophylaxis against post-operative nausea and vomiting (PONV). This double-blind clinical trial included the 195 patients who were referred to Taleghani Hospital (in Arak, Iran) for cesarean section (C/S) under spinal anesthesia, and then the subjects were assigned to three equally sized groups using block randomization. Participants in the first, second, and control groups received 8 mg, 4 mg of ondansetron, and normal saline, respectively, 5 minutes before surgery. A final volume of 5 cc was prepared by adding normal saline. Participants were examined for headache one week after surgery, and then data analysis was performed using SPSS 20. The incidence of post-spinal headache was significantly higher in the placebo group than in the ondansetron 8-mg and 4-mg groups at 24 hours after surgery (P < 0.010). But, no significant difference was observed between two ondansetron groups (P ≤ 0.05). The overall incidence of the headache was generally lower in ondansetron 8-mg (26.66% vs. 33.68.05%) and 31.66% in ondansetron 4-mg (P < 0.001). Moreover, the PONV incidence was significantly higher in the placebo group than in the other two groups at 24 hours (P < 0.001). The hemodynamic variables were same in three groups. The ondansetron 8-mg dose can be effective to prevent headache after spinal anesthesia for C/S. Moreover, the ondansetron 8-mg and ondansetron 4-mg have same effect in control of PONV after spinal anesthesia for C/S.

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Section: S Ubjects and M Ethodsmentioning

confidence: 99%

Ondansetron 8 mg and 4 mg with normal saline against post-operative headache and nausea/vomiting after spinal anesthesia: a randomized double-blind trial

et al. 2018

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“…Therefore, the spinal block is reported as a common anesthetic method for patients undergoing lower limb orthopedic surgery, such as dynamic hip screw (DHS) operations. 1 2 Postoperative pain control is a substantial problem in spinal anesthesia, because of using only local anesthetics with a relatively short duration of action. Hence, early analgesic interventions are required postoperatively.…”

Section: Introductionmentioning

confidence: 99%

Change in saturation oxygen and hemodynamic responses by adding intrathecal dexmedetomidine vs. sufentanil to bupivacaine in patients undergoing dynamic hip screw operation: a randomized clinical trial

et al. 2020

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Sufentanil (SUF) and dexmedetomidine (DEX) are used as bupivacaine in the spinal technique that providing stable hemodynamic conditions with least side effects. This study aimed to compare the change in saturation oxygen and hemodynamic responses after intrathecal DEX and SUF as adjuvants to bupivacaine in patients undergoing dynamic hip screw. This clinical trial was conducted with 80 patients referring to Valiasr Hospital, Arak, Iran, who were randomly assigned to two groups ( n = 40): DEX group (8 mg bupivacaine with 5 μg DEX) and SUF group (8 mg bupivacaine with 2.5 μg SUF). The pain severity was lower in DEX group at different hours and the systolic pressure and diastolic blood pressure were lower in DEX group than in SUF group after surgery. Saturation oxygen was generally lower and more stable in DEX group but there was no significant difference between two groups. The incidence of sensory and motor block was lower in DEX group than in SUF group, but the duration of assessment of sensory block was lower in SUF group than in DEX group. DEX relieves pain up to 24 hours postoperatively. Nevertheless, Care should be taken to avoid the DEX induced shivering in patients. The study was approved by Ethical Committee of Arak University of Medical Sciences by IR.ARAKMU.REC.1395.32 code on April 25, 2016 and was registered in Iranian Registry of Clinical Trials by code number: IRCT2017050220258N45 on August 4, 2017.

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“…Gabapentin binds to the alpha-2/delta auxiliary subunits of LTCCs, and exerts inhibitory actions on trafficking and activation kinetics of LTCCs [153]. Gabapentin can be used as an anti-nausea and antiemetic agent in postoperative nausea and vomiting [154,155] and in CINV [156,157]. (5) LTCC antagonists (nifedipine and amlodipine) are broad-spectrum antiemetics when delivered systemically against diverse specific and nonselective emetogens.…”

Section: Introductionmentioning

confidence: 99%

Calcium and Signal Transduction

2018

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He has 26 years of teaching and over 30 years of research experience in cardiovascular and autonomic pharmacology and physiology. His current research interests lie in the area of age related alterations in mechanisms that modulate cerebral blood flow in normal aging and with cognitive disorders such as Alzheimer's disease. He has over 50 publications including book chapters and has received research funding from the American Heart Association (AHA), Association for Aging Research (AFAR) and National Institutes of Health (NIH). He is reviewer for various peer reviewed journals, including American Journals of Physiology (AJP) and Associated Societies for Pharmacology and Experimental Therapeutics (ASPET). He currently serves as the Vice Chair of Phar-

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Protecting effect of gabapentin for nausea and vomiting in the surgery of cesarean after spinal anesthesia

Cited by 8 publications

References 9 publications

Ondansetron 8 mg and 4 mg with normal saline against post-operative headache and nausea/vomiting after spinal anesthesia: a randomized double-blind trial

Ondansetron 8 mg and 4 mg with normal saline against post-operative headache and nausea/vomiting after spinal anesthesia: a randomized double-blind trial

Change in saturation oxygen and hemodynamic responses by adding intrathecal dexmedetomidine vs. sufentanil to bupivacaine in patients undergoing dynamic hip screw operation: a randomized clinical trial

Calcium and Signal Transduction

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