Background:Nausea and vomiting are the most common effects after cesarean delivery with spinal anesthesia that was associated with problems such as pneumonia, delay in patient discharge, electrolyte abnormalities, and the maternal dissatisfaction.Objectives:The aim of this study was to evaluate the effects of gabapentin in preventing nausea and vomiting after spinal anesthesia in cesarean delivery.Patients and Methods:This study as a double-blind clinical trial was done on 200 candidates of cesarean with a random distribution. Patients without cardiovascular diseases and in 1 and 2 American Society of Anesthesiologists were divided into two groups. Treatment group received 600 mg capsule (gabapentin) 1 h before surgery and the control group received placebo. The severity of nausea and vomiting were evaluated according to 4 Scores every hour to 4 h after the withdrawal of mother from the recovery section.Results:In this study, there is no significant difference in demographic information between these two groups. In the 1st h, there is a significant difference between the severity of nausea and vomiting in these two groups, but there is not a significant difference between 2 and 4 h after surgery. However, the incidence of nausea between the two groups shows a significant correlation.Conclusions:A single dose of gabapentin 1 h before cesarean delivery decreases the incidence of nausea and vomiting after surgery.