Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia

Yang, Fang; Suo, Yourui; Chen, Dongli; Li, Tong

doi:10.5582/bst.2016.01056

Cited by 26 publications

(13 citation statements)

References 39 publications

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“…To address more specifically the role of polyphenols, many studies have used purified polyphenol extracts in animal models of human diseases. For example, Yang et al [62] supplemented polyphenol extracts of the sea buckthorn berry to rats fed a high fat diet (HFD) and found that the extract reduced TNFα and IL-6 levels, while increasing the activity of antioxidant enzymes, compared to HFD alone [62]. These findings indicate that polyphenols can reduce inflammation and increase the antioxidant capacity, both of which may provide protection against atherosclerosis.…”

Section: Polyphenols In Human Healthmentioning

confidence: 99%

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

2018

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Aging is a major risk factor in the development of chronic diseases affecting various tissues including the cardiovascular system, muscle and bones. Age-related diseases are a consequence of the accumulation of cellular damage and reduced activity of protective stress response pathways leading to low-grade systemic inflammation and oxidative stress. Both inflammation and oxidative stress are major contributors to cellular senescence, a process in which cells stop proliferating and become dysfunctional by secreting inflammatory molecules, reactive oxygen species (ROS) and extracellular matrix components that cause inflammation and senescence in the surrounding tissue. This process is known as the senescence associated secretory phenotype (SASP). Thus, accumulation of senescent cells over time promotes the development of age-related diseases, in part through the SASP. Polyphenols, rich in fruits and vegetables, possess antioxidant and anti-inflammatory activities associated with protective effects against major chronic diseases, such as cardiovascular disease (CVD). In this review, we discuss molecular mechanisms by which polyphenols improve anti-oxidant capacity, mitochondrial function and autophagy, while reducing oxidative stress, inflammation and cellular senescence in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). We also discuss the therapeutic potential of polyphenols in reducing the effects of the SASP and the incidence of CVD.

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Section: Polyphenols In Human Healthmentioning

confidence: 99%

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

2018

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“…have significant cardioprotective effects and have been shown to play a beneficial role in improving myocardial infarction induced by I/R via anti-oxidative and anti-apoptotic activities [88,89,90]. In addition, bilberry, black raspberry, and sea buckthorn berries improved serum lipid profiles and promoted a hypocholesterolemic effect, which protected against hypercholesterolemia and prevented atherosclerosis [91,92,93]. Additionally, jujube ( Zizyphus jujub a) and blackberry ( Rubus allegheniensis Port.)…”

Section: Experimental Studiesmentioning

confidence: 99%

Fruits for Prevention and Treatment of Cardiovascular Diseases

et al. 2017

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Cardiovascular diseases (CVDs) are leading global health problems. Accumulating epidemiological studies have indicated that consuming fruits was inversely related to the risk of CVDs. Moreover, substantial experimental studies have supported the protective role of fruits against CVDs, and several fruits (grape, blueberry, pomegranate, apple, hawthorn, and avocado) have been widely studied and have shown potent cardiovascular protective action. Fruits can prevent CVDs or facilitate the restoration of morphology and functions of heart and vessels after injury. The involved mechanisms included protecting vascular endothelial function, regulating lipids metabolism, modulating blood pressure, inhibiting platelets function, alleviating ischemia/reperfusion injury, suppressing thrombosis, reducing oxidative stress, and attenuating inflammation. The present review summarizes recent discoveries about the effects of fruits on CVDs and discusses potential mechanisms of actions based on evidence from epidemiological, experimental, and clinical studies.

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“…[ 104 ] Animal studies have also found that rats with hyperlipidemia when supplemented with sea buckthorn berries enhanced expression of eNOS mRNA and protein and enhanced activity of endogenous antioxidant enzymes, which suppressed inflammatory markers TNF‐α and IL‐6. [ 105 ] Although Aronia berry extract had no effect on the NF‐κB pathway, it did suppress the signal transducer and activator of transcription 3(STAT3)/ interferon regulatory transcription factor‐1 (IRF1) pathway through an inhibition of the phosphorylation of STAT3. As a result, the expression of inflammatory cytokines such as IL‐1β and IL‐6 decreased, and the expression of VCAM‐1 (which is regulated by IRF1) was also suppressed by Aronia berry extract.…”

Section: Combating Endothelial Inflammationmentioning

confidence: 99%

Potential Benefits of Berry Anthocyanins on Vascular Function

Festa

Boit

Hussain

et al. 2021

Molecular Nutrition Food Res

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Cardiovascular disease (CVD), such as hypertension and atherosclerosis, is the leading cause of global death. Endothelial dysfunction (ED) is a strong predictor for most CVD making it a therapeutic target for both drug and nutrition interventions. It has been previously shown that polyphenols from wine and grape extracts possess vasodilator activities, due to the increased expression and phosphorylation of the endothelial nitric oxide synthase (eNOS), and consequent vasodilator nitric oxide (NO) production. This is vital in the prevention of ED, as NO production contributes to the maintenance of endothelial homeostasis. Moreover, polyphenols have the ability to inhibit reactive oxygen species (ROS), which can cause oxidative stress, as well as suppress the upregulation of inflammatory markers within the endothelium. However, while the majority of the research has focused on red wine, this has overshadowed the potential of other nutritional components for targeting ED, such as the use of berries. Berries are high in anthocyanin flavonoids a subtype of polyphenols with studies suggesting improved vascular function as a result of inducing NO production and reducing oxidative stress and inflammation. This review focuses on the protective effects of berries within the vasculature.

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Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia

Cited by 26 publications

References 39 publications

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

Fruits for Prevention and Treatment of Cardiovascular Diseases

Potential Benefits of Berry Anthocyanins on Vascular Function

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