Protection of Liver Microsomal Membranes from Lipid Peroxidation by Garlic Extract

Horie, Toshiharu; Murayama, Tohru; Mishima, Toyohiro; Itoh, Fumiaki; Minamide, Yoshiyuki; Fuwa, Tohru; Awazu, Shoji

doi:10.1055/s-2006-962081

Cited by 70 publications

(25 citation statements)

References 6 publications

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“…A large number of pharmacological studies have shown that AGE exerts anti-fatigue, 11) anti-stress, 11) and anti-oxidation [8][9][10] effects. Ushijima et al have been reported that antifatigue effect of AGE is assessed by prolongation of running time under severe condition (30 m/min) using a treadmill in mice, suggesting that AGE prevents an acute physical fatigue.…”

Section: Discussionmentioning

confidence: 99%

“…5,6) Aged garlic extract (AGE), which is extracted for more than 10 months, is less irritating and toxic. 5,7) A large number of pharmacological studies have demonstrated that AGE possesses anti-oxidative, [8][9][10] anti-stress, 11) immunomodulating, 12) cardiovascular 13,14) and hepatoprotective 15,16) properties. Moreover, AGE has been shown to be superior to raw garlic in terms of its anti-oxidation properties, and amelioration of physiological and psychological stress.…”

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confidence: 99%

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Aged Garlic Extract Ameliorates Physical Fatigue

Morihara

Ushijima

Kashimoto

et al. 2006

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Aged Garlic Extract Ameliorates Physical Fatigue

Morihara

Ushijima

Kashimoto

et al. 2006

Biological & Pharmaceutical Bulletin

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“…Garlic has been extensively studied and has been shown to have a number of medicinal properties, including immunomodulatory, hepatoprotective, antimutagenic, anticarcinogenic, and antioxidant effects. [3][4][5][6] Various garlic preparations and components have also been shown to have antioxidant activity, including the ability to lower reactive oxygen species in vivo. [7][8][9] We recently reported that using a model of DOX-induced heart damage in rats, pretreatment with aged garlic extract (AGE), a strong antioxidant, offered protection against DOXinduced myocardial cell damage.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Cardioprotective Effect of Aged Garlic Extract Against Doxorubicin-Induced Cardiotoxicity

et al. 2011

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Aged garlic has been extensively studied and has been shown to have a number of medicinal properties, including immunomodulatory, hepatoprotective, antimutagenic, anticarcinogenic, and antioxidant effects. The objective of this study was to investigate the mechanisms of the cardioprotective effect of aged garlic extract (AGE), a widely used herbal medicine with potent antioxidant activity, against doxorubicin-induced cardiotoxicity. Moreover, the study investigated if the cardioprotective effect of AGE might be at the expense of the antitumor effect of the anticancer drug doxorubicin (DOX). Primary cultured neonatal rat cardiac myocytes were treated with DOX, AGE, and their combination for 24 hours. DOX increased p53 and caspase 3 activity-induced apoptotic cell death, whereas AGE pretreatment suppressed the action of DOX. AGE pretreatment did not interfere with the cytotoxic activity of DOX, but it increased the DOX uptake into tumor cells and increased the long term survivors of tumor-bearing mice from 30% to 70%. In conclusion, DOX impairs viability of cardiac myocytes, at least partially by activating the p53-mediated apoptotic signaling. AGE can effectively and extensively counteract this action of DOX and may potentially protect the heart from severe toxicity of DOX. At the same time, AGE did not interfere with antitumor activity of DOX.

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“…This reaction generates very reactive oxygen compounds, which in humans are responsible for causing or accelerating chronic disease states such as cardiovascular, neoplastic inflammatory and amyloidosis and aging. The antioxidant effects of garlic extracts and their components have been demonstrated and quantified by a variety of assays (Horie et al, 1989;Yamasaki et al, 1994). Ide et al (1996) reported that garlic and its major organosulphur constituents have a scavenging effect on hydrogen peroxide and inhibit the chain oxidation induced by a hydrophilic radical initiator.…”

Section: Introductionmentioning

confidence: 99%

Prevention of fumonisin‐induced maternal and developmental toxicity in rats by certain plant extracts

Abdel-Wahhab

Hassan

Amer

et al. 2004

J of Applied Toxicology

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In earlier work we have reported that garlic and cabbage extracts can protect laboratory animals from the toxic effects of different mycotoxins. Previous research demonstrated that fumonisin (FB) induced developmental effects in mice, rats and hamsters. The objectives of the present study were to utilize the pregnant rat as an in vivo model to compare the potential of garlic and cabbage seed extracts to prevent the developmental toxicity of FB and the effects of these extracts on sphingolipid metabolism in dam and foetus livers. Six treatment groups included a control group, a group fed on an FB-containing diet (150 mg kg(-1) feed) and groups treated orally with garlic or cabbage extracts (5 mg kg(-1) body wt.) with or without FB during gestation days 6-15. Evaluations of toxicity were performed on day 20. These include: maternal (mortality, body weight, feed intake and litter weight), developmental (embryonic resorption, foetal body weight, foetal soft-tissue anomalies and foetal skeletal examinations) and maternal and foetal sphingolipid metabolism. Fumonisin alone resulted in significant decreases in feed intake, body weight gain, litter weight, number of live foetuses and foetal body weight, whereas it increased significantly the number of resorbed foetuses and the number of skeletal malformations (30.4% for skull and 26.08% for sternebrae) and also increased the sphinganine/sphingosine (Sa/So) ratio in dam but not fetus livers. Garlic alone or plus FB was comparable to the control regarding all the tested parameters. On the other hand, cabbage seed extract alone or plus FB resulted in 10% maternal mortality and a decrease in maternal body weight and litter weight. It resulted in 4.65% skull malformations in foetuses but it was comparable to the control with regard to the other tested parameters. It could be concluded that both garlic and cabbage seed extracts have protective effects in pregnant rats. Moreover, garlic extract was found to have a greater protective effect than cabbage seed extract.

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Protection of Liver Microsomal Membranes from Lipid Peroxidation by Garlic Extract

Cited by 70 publications

References 6 publications

Aged Garlic Extract Ameliorates Physical Fatigue

Aged Garlic Extract Ameliorates Physical Fatigue

Mechanisms of Cardioprotective Effect of Aged Garlic Extract Against Doxorubicin-Induced Cardiotoxicity

Prevention of fumonisin‐induced maternal and developmental toxicity in rats by certain plant extracts

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