Protective activity of tetracycline analogs against the cytopathic effect of the human immunodeficiency viruses in CEM cells

Lemaître, M.; Guétard, Denise; Hénin, Y.; Montagnier, Luc; Zerial, Aurelio

doi:10.1016/0923-2516(90)90052-k

Cited by 102 publications

(38 citation statements)

References 13 publications

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“…Moreover, the organism has been found in autopsy specimens from non-AIDS patients who died of a flulike illness (711). T cells from HIV-infected individuals have been shown to respond actively to mycoplasma antigens (658), and their potential role as superantigens has also been proposed (see Section XVII C).…”

Section: A Infection By Other Virusesmentioning

confidence: 99%

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Pathogenesis of Human Immunodeficiency Virus Infection

Levy¹

1989

Annals of the New York Academy of Sciences

222

290

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Section: A Infection By Other Virusesmentioning

confidence: 99%

“…Some studies have focused on cell culture events in which noncytopathic or relatively less cytopathic HIV strains were found to be more cytopathic when infecting PBMC in the presence of a variety of different mycoplasmas (658,713). Whereas the mycoplasmas reduced syncytium formation in culture, cell death was increased.…”

Section: A Infection By Other Virusesmentioning

confidence: 99%

Pathogenesis of Human Immunodeficiency Virus Infection

Levy¹

1989

Annals of the New York Academy of Sciences

222

290

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“…Besides M. fermentans, also Mycoplasma genitalium, Mycoplasma pirum and Mycoplasma penetrans have been isolated from HIV-infected individuals [7,8], A pos sible role of mycoplasmas as co-factor was suggested after in vitro studies with HIV-producing cell lines. In these studies it was demonstrated that mycoplasmas were able to fuse with T lymphocytes [9,10], that mycoplasmas en hanced the cytotoxic effects of HIV in cultures of T lym phocytes [11][12][13], and that elimination of mycoplasmas from HIV-producing cells prevented cell killing without affecting virus replication [14]. Whether mycoplasma infections simply represent oppor tunistic infections or whether they enhance the pathogeni city of HIV and play a role in the progression to AIDS is still unclear.…”

Section: Introductionmentioning

confidence: 99%

No evidence of mycoplasmas in peripheral blood mononuclear cell fraction of HIV-infected patients

et al. 1994

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Summary: In this study, the prevalence of mycoplasmas in peripheral blood mononuclear cells (PBMC) from HIV-infected individuals was investigated using a mycoplasma genusspecific PCR assay. No mycoplasmas were detected in the PBMC samples from any of the 25 HIV-infected individuals (CDC 2, n = 8; CDC 3, n = 2; CDC 4, n = 15) or ten HIV-sero negative controls. As an internal control, HIV specific sequences were detected in the sam ples from all HIV-seropositives. These negative results do not support a suggested role of mycoplasmas as co-factor in the progression of HIV infection towards AIDS.

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“…These observations suggest the possibility that M. fermentans has a role in the pathogenesis of rheumatoid arthritis. Recently, interest in M. fermentans has increased because it is frequently isolated from, or detected in, various tissues and blood of AIDS patients (1,4,12,16) and has been implicated in the disruption of the immune system. M. fermentans also has high affinity for HTLV-I-infected T-cells (26).…”

mentioning

confidence: 99%

Monoclonal Antibody against Mycoplasma fermentans‐Specific Aminoglycoglycerolipid

Matsuda¹,

Ichinose

et al. 2000

Microbiology and Immunology

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Previously, we reported that Mycoplasma fermentans has specific antigens (phosphocholinecontaining glycoglycerolipids: GGPL-I and GGPL-III) and discussed the possibility of their pathogenic role. In this paper, we report the characterization of a monoclonal antibody (MF-III-1) specific to GGPL-III (phosphocholine-containing aminoglycoglycerolipid) using methods of electron microscopy, immunofluorescence cell surface staining, laser scanning microscopy, immunoelectron microscopy, and thin-layer chromatography immunostaining. The MF-III-1 antibody specifically recognized M. fermentans attached to the surface of HTLV-I-infected human helper T-cells, and it did not cross-react with other lipids nor with human T-cell antigens. Since MF-III-1 distinguishes GGPL-III from GGPL-I, the binding site may include a serinol (2-amino-1,3-propanediol) residue of GGPL-III. MF-III-1 is useful for the in vitro study of M. fermentans, and may also be useful as a tool for the study of the involvement of M. fermentans in human diseases.

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Protective activity of tetracycline analogs against the cytopathic effect of the human immunodeficiency viruses in CEM cells

Cited by 102 publications

References 13 publications

Pathogenesis of Human Immunodeficiency Virus Infection

Pathogenesis of Human Immunodeficiency Virus Infection

No evidence of mycoplasmas in peripheral blood mononuclear cell fraction of HIV-infected patients

Monoclonal Antibody against Mycoplasma fermentans‐Specific Aminoglycoglycerolipid

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