2019
DOI: 10.1016/j.phymed.2019.152865
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Protective effect of 7,3′,4′-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo

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Cited by 30 publications
(25 citation statements)
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“…Therefore, whether APAP overdose-induced inflammation promotes the progression of liver damage or acts as a cellular defense against toxicity remains controversial. Nonetheless, most studies identified anti-inflammation as a therapeutic strategy to protect against 14 Oxidative Medicine and Cellular Longevity APAP overdose-induced liver damage [37][38][39][40]. In this study, we found that IMP could significantly inhibit the increase in proinflammatory cytokines including TNF-α, IL-1β, and IL-6 in the liver of APAP-WT mice in an FXR-dependent manner.…”
mentioning
confidence: 58%
“…Therefore, whether APAP overdose-induced inflammation promotes the progression of liver damage or acts as a cellular defense against toxicity remains controversial. Nonetheless, most studies identified anti-inflammation as a therapeutic strategy to protect against 14 Oxidative Medicine and Cellular Longevity APAP overdose-induced liver damage [37][38][39][40]. In this study, we found that IMP could significantly inhibit the increase in proinflammatory cytokines including TNF-α, IL-1β, and IL-6 in the liver of APAP-WT mice in an FXR-dependent manner.…”
mentioning
confidence: 58%
“…ROS in cells was measured using an H2DCFDA probe as described previously (Zhao et al, 2019). To measure ROS levels in the liver, cold liver homogenate was centrifuged (10,000 g, 15 min, 4°C); supernatants were incubated with 10 μM H 2 DCFDA in the dark for 1 h and subsequently transferred to a black-walled clear-bottomed 96-well plate.…”
Section: Measurement Of Reactive Oxygen Species In the Liver And Cellsmentioning
confidence: 99%
“…Apigenin (API) or versulin (4′,5,7-trihydroxyflavone) is a natural flavonoid derived from Matricaria chamomilla with high antioxidant capacity. Previous studies have revealed that flavonoids can protect against different types of hepatopathy through anti-inflammatory and antioxidant mechanisms, especially hepatopathy that is associated with AP-induced liver damage (Jing et al, 2018;Shi et al, 2018;Zhao et al, 2019). In addition, previous studies have demonstrated that API can protect against various liver injuries caused by alcohol (Wang et al, 2017), lipopolysaccharides (Zhou et al, 2017), and ischemia/reperfusion (Tsaroucha et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…4',5,7-trihydroxyflavone (Apigenin, API, Versulin) is a wellknown flavonoid isolated from Matricaria chamomilla. In our previous research, we found that flavonoids can protect against various liver diseases, especially acetaminophen-induced liver damage, via anti-oxidation and anti-inflammatory mechanisms (Jing et al, 2018;Shi et al, 2018;Zhao et al, 2019). API can protect against various liver injuries caused by alcohol (Wang et al, 2017), lipopolysaccharide (Zhou et al, 2017), ischemia/ reperfusion (Tsaroucha et al, 2016), and CCl 4 (Simeonova et al, 2014).…”
Section: Introductionmentioning
confidence: 98%