Protective effect of a 50% hydroalcoholic fruit extract ofEmblica officinalis against anti-tuberculosis drugs induced liver toxicity

Abstract

The present report showed the hepatoprotective property of a 50% hydroalcoholic extract of the fruits of Emblica officinalis (fruit) (EO-50) against antituberculosis (anti-TB) drugs-induced hepatic injury. The biochemical manifestations of hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies were done on suspension cultures of rat hepatocytes while sub-acute studies were carried out in rats. The hepatoprotective activity of EO-50 was found to be due to its membrane stabilizing, antioxidative and CYP 2E1 inhibitory effects.

Protective Effect of Bee Propolis Against Anti-Tuberculosis Drugs (Rifampicin and Isoniazid)-Induced Hematological Toxicity in Sprague Dawley Rats

“…Propolis has imperative pharmacological properties which can be used for a wide range of purposes as anti-inflammatory, antioxidant, and antibacterial agents [1]. Various plant derived drugs (such as Pongamia pinnata, Emblica officinalis, and Rubia cordifolia) were reported to be the best alternative drug for the anti-tuberculosis (TB) drug-induced toxicity [2,3].…”

Influence ofEmblica officinalisaqueous extract on growth and antioxidant defense system of human hepatoma cell line (HepG2)

“…In the current model, E. officinalis significantly diminished the levels of LHP as evident by lower levels of LHP. Earlier few workers have consistently shown that E. officinalis reduced pro-oxidant-induced lipid peroxidation (LPO) in various tissues (Anilakumar et al, 2007;Sultana et al, 2005;Tasduq et al, 2005). Previous studies reported no change in basal LPO among rats administered aqueous E. officinalis extract in hepatic tissues (Anilakumar et al, 2007), tannin-enriched E. officinalis fractions in heart and brain of rats (Bhattacharya et al, 2000).…”

“…Few studies in rodent models have demonstrated efficacy of E. officinalis in reversal of hepatotoxicity induced by dimethyl hydrazine (Anilakumar et al, 2007); ethanol (Pramyothin et al, 2006); antituberculosis drugs (Tasduq et al, 2005), and CCl 4 (Sultana et al, 2005). Although the underlying basis of such efficacy of E. officinalis is largely attributed to its antioxidant effect, mechanistic approaches to understand the efficacy of aqueous extract in cell models are rather limited.…”

Negundoside, an irridiod glycoside from leaves of Vitex negundo , protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride

“…In vitro effect of NG on superoxide anion radical generation was studied as described previously [35] . Two reaction systems used were: (a) enzymic ; (b) nonenzymic.…”