Protective Effect of a Fucose-Rich Fucoidan Isolated from Saccharina japonica against Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish

Su, Wanchun; Wang, Lei; Fu, Xiaoting; Ni, Liying; Duan, Delin; Xu, Jiachao; Gao, Xin

doi:10.3390/md18060316

Cited by 32 publications

(11 citation statements)

References 46 publications

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“…These results demonstrated that fucoidan could effectively protect HaCaT cells against UVB-induced cell death and possibly achieved this by scavenging intracellular ROS. Su et al have evaluated the photoprotective effect of fucoidan (LJSF4) isolated from Saccharina japonica in HaCaT cells [ 40 ]. The results indicated LJSF4 contains 56.55% carbohydrate and 30.72% sulfate contents, and it increased the viability of UVB-irradiated HaCaT cells by 16.13% at the concentration of 100 μg/mL [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…Su et al have evaluated the photoprotective effect of fucoidan (LJSF4) isolated from Saccharina japonica in HaCaT cells [ 40 ]. The results indicated LJSF4 contains 56.55% carbohydrate and 30.72% sulfate contents, and it increased the viability of UVB-irradiated HaCaT cells by 16.13% at the concentration of 100 μg/mL [ 40 ]. Compared with the present results, LJSF4 possesses a slightly stronger activity than the fucoidan isolated from H. fusiforme , possibly owing to its higher sulfate content.…”

Section: Resultsmentioning

confidence: 99%

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Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Wang

Kim

et al. 2020

Marine Drugs

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Previous studies suggested that fucoidan with a molecular weight of 102.67 kDa, isolated from Hizikia fusiforme, possesses strong antioxidant activity. To explore the cosmeceutical potential of fucoidan, its anti-photoaging and anti-melanogenesis effects were evaluated in the present study. The anti-photoaging effect was investigated in ultraviolet (UV) B-irradiated human keratinocytes (HaCaT cells), where fucoidan effectively reduced the intracellular reactive oxygen species level and improved the viability of the UVB-irradiated cells without any cytotoxic effects. Moreover, fucoidan significantly decreased UVB-induced apoptosis in HaCaT cells by regulating the protein expression of Bax, Bcl-xL, PARP, and Caspase-3 in HaCaT cells in a concentration-dependent manner. The anti-melanogenesis effect of fucoidan was evaluated in B16F10 melanoma cells that had been stimulated with alpha-melanocyte-stimulating hormone (α-MSH), and fucoidan treatment remarkably inhibited melanin synthesis in α-MSH-stimulated B16F10 cells. Further studies indicated that fucoidan significantly suppressed the expression of tyrosinase and tyrosinase-related protein-1 and -2 (TRP-1 and-2) in B16F10 cells by down-regulating microphthalmia-associated transcription factor (MITF) through regulation of the ERK–MAPK (extracellular signal regulated kinase-mitogen activated protein kinase) pathway. Taken together, these results suggest that fucoidan isolated from H. fusiforme possesses strong anti-photoaging and anti-melanogenesis activities and can be used as an ingredient in the pharmaceutical and cosmeceutical industries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Wang

Kim

et al. 2020

Marine Drugs

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“…Fucoidans are a family of sulfated polyfucose polysaccharides extracted from brown seaweeds. These substances possess various pharmacological properties that exert antitumor, immunomodulatory, antioxidant, and anti-inflammatory effects (18,19). Previous studies have demonstrated that fucoidans also have antiphotoaging effects against UV irradiation and can be used as an ingredient in pharmaceuticals (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging

Jing¹,

Guo²,

Zhong³

et al. 2021

Ann Transl Med

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Background: Exposure to ultraviolet (UV) radiation (UVB and UVA) is the most well-known extrinsic factor that induces skin aging. Fucoidan has been shown to possess antiphotoaging effects against UV irradiation and can be used as an ingredient in the pharmaceutical industry. The present study evaluated the photoprotective effect of fucoidan purified from Undaria pinnatifida (UPF) on UV-induced skin photoaging and explored its potential molecular mechanism.Methods: To evaluate the effect of UPF on UV-induced skin aging, HaCaT cells and HFF-1 cells were pretreated with or without UPF and then exposed to UVB and UVA radiation, respectively, and the levels of cellular senescence, reactive oxygen species (ROS) production and mitochondrial dysfunction were evaluated. The mitochondrial ROS (mROS) was stained through MitoSOX, and the confocal microscope was used to capture the images. For further exploration of AMPK/SIRT-1/PGC-1α signaling, western blot was employed. Results:The results demonstrated that pretreatment of HaCaT and HFF-1 cells with UPF ameliorated cellular senescence, ROS and mROS overproduction, and mitochondrial dysfunction caused by UV exposure. This research also revealed that UPF could activate the AMPK/SIRT-1/PGC-1α signaling pathway to promote mitochondrial biogenesis.Conclusions: UPF can ameliorate UV-induced skin photoaging through inhibition of ROS production via the alleviation of mitochondrial dysfunction by regulating the SIRT-1/PGC-1α signaling pathway.

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“…The photoprotective activity of fucoidan has been studied using UVB irradiated HaCaT and human foreskin fibroblast (HS 68) cells, zebrafish, and in vivo models [ 19 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. The earliest study on the photoprotective activity of fucoidan was carried out by Kim et al in 2008.…”

Section: Seaweed Compounds As Potential Sources Of Anti-photoagingmentioning

confidence: 99%

Anti-Photoaging and Potential Skin Health Benefits of Seaweeds

2021

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The skin health benefits of seaweeds have been known since time immemorial. They are known as potential renewable sources of bioactive metabolites that have unique structural and functional features compared to their terrestrial counterparts. In addition, to the consciousness of green, eco-friendly, and natural skincare and cosmetics products, their extracts and bioactive compounds such as fucoidan, laminarin, carrageenan, fucoxanthin, and mycosporine like amino acids (MAAs) have proven useful in the skincare and cosmetic industries. These bioactive compounds have shown potential anti-photoaging properties. Furthermore, some of these bioactive compounds have been clinically tested and currently available in the market. In this contribution, the recent studies on anti-photoaging properties of extracts and bioactive compounds derived from seaweeds were described and discussed.

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Protective Effect of a Fucose-Rich Fucoidan Isolated from Saccharina japonica against Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish

Cited by 32 publications

References 46 publications

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging

Anti-Photoaging and Potential Skin Health Benefits of Seaweeds

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