Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

İlbey, Yusuf Özlem; Özbek, Emin; Çekmen, Mustafa; Şimşek, Abdülmuttalip; Ötünçtemur, Alper; Somay, Adnan

doi:10.1093/humrep/dep058

Cited by 169 publications

(179 citation statements)

References 58 publications

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“…The protective effect of curcumin on induced tissue damage due to free radicals has been observed previously in a number of experimental models. [14][15][16][17] Previous studies have demonstrated that curcumin also exhibits an antioxidant property as well as anti-inflammatory, immunomodulatory, anticancer, and antiangiogenic properties via its pleiotropic effects on genes and cell-signaling pathways at multiple levels. [18] A recent experimental SCI study showed that curcumin blocked apoptosis and neuron loss, restrained astrocyte activation, and significantly improved neurologic deficit.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant effects of curcumin in spinal cord injury in rats

Kavakli

Koca²,

Alıcı³

2011

Ulus Travma Acil Cerrahi Derg

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AMAÇBu deneysel çalışma, sıçanlarda spinal kord yaralanmasın-da curcuminin antioksidan etki yoluyla faydasını araştır-mak için yapıldı. GEREÇ VE YÖNTEMYirmi dört adet Wistar albino sıçan 3 gruba randomize edildi. Spinal kord yaralanması ağırlık düşürme modeliyle gerçekleştirildi. Grup 1'e laminektomi ardından spinal kord yaralanması uygulandı ve herhangi bir tedavi verilmedi. Grup 2'ye laminektomi ardından spinal kord yaralanması uygulandı ve curcumin verildi (200 mg/kg/gün ağızdan). Grup 3'e laminektomi ardından spinal kord yaralanması uygulandı ve metilprednizolon verildi (30 mg/kg periton içine), 24 saat sonra tüm sıçanlardan kan örnekleri alındı, sonra serum süperoksit dismutaz (SOD) ve malondialdehit (MDA) düzeyleri belirlendi ve elde edilen sonuçlar karşılaştırıldı. BULGULARCurcumin grubunda SOD düzeyi kontrol ve metilprednizolon grubundan daha yüksekti (p<0,001 ve p<0,012). Curcumin grubunda MDA düzeyi kontrol grubundan daha düşüktü (p<0,042). Benzer şekilde metilprednizolon grubunda MDA düzeyi kontrol grubundan daha düşüktü (p<0,001). SONUÇBu çalışmanın sonuçları curcuminin etkin biçimde oksidatif hasara karşı spinal kord dokularını koruduğunu gös-terir.Anahtar Sözcükler: Antioksidan; curcumin; malondialdehit; spinal kord yaralanması; süperoksit dismutaz.

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Section: Resultsmentioning

confidence: 99%

Antioxidant effects of curcumin in spinal cord injury in rats

Kavakli

Koca²,

Alıcı³

2011

Ulus Travma Acil Cerrahi Derg

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“…The biochemical results of these workers have shown the generation of free radicals in each case as they demonstrated that cisplatin treatment was characterized by a significant increase in tissue malon-dialdehyde level compared to normal control (Ilbey et al, 2009). This study investigated the associated response of neural and other parameters in response to cisplatin toxicity.…”

Section: Discussionmentioning

confidence: 99%

Tomato pomace powder ameliorated cisplatin-induced microanatomical alterations in brain of Wistar rats

Owoeye¹,

Onwuka²

2015

Int. J. Bio. Chem. Sci

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Cisplatin chemotherapy is associated with neurotoxicity. Oxidative stress has been associated with its pathogenesis. Tomato (Lycopersicon esculentum) pomace powder (TPP) may be a preventive agent by virtue of its known antioxidant property. The possible protective role of TPP against cisplatin-induced alteration of the microanatomy of rat brain was investigated. Thirty rats were divided equally into five groups: control, propylene glycol, TPP, cisplatin (10 mg/kg i.p.); TPP 50 mg/kg plus cisplatin (10 mg/kg i.p.). All administrations were oral by gastric gavage given for 24 days except cisplatin which was given intraperitoneally on days 10 and 17. Rats were euthanized on the 25 th day of treatment. Blood parameters checked, neurobehavioural tests done and brain tissue were examined with regards to micro-anatomical parameters. Cisplatin caused a significant (p<0.05) reduction in lymphocytes. Neurobehavioural results showed that cisplatin caused a reduction in line crossing, rearing and forelimb grip. Cisplatin caused histological alterations in the cerebellum, dentate gyrus and Cornu Ammonis3 (CA3). Co-treatment of cisplatin with TTP ameliorated these haematological, neurobehavioural and histological alterations. In conclusion, Lycopersicon esculentum (as tomato pomace powder) demonstrated neuroprotection against cisplatin-induced alteration of microanatomy of rat cerebellum, dentate gyrus and Cornu Ammonis3 of rat brain.

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“…Th e eff ects of the curcumin on inducible nitric oxide synthase (iNOS) expression, nuclear factor-kappa B (NF-kB) activation, and MAPK in the pathogenesis of testicular damage induced by cisplatin (CIS) have been investigated (Ilbey et al 2009). Curcumin (200 mg/kg, p.o.)…”

Section: Th E Eff Ect Of C Longa and Curcumin On Male Reproductive Smentioning

confidence: 99%

“…Curcumin (200 mg/kg, p.o.) increased plasma testosterone levels, GSH levels, and glutathione peroxidase (GSH-Px) activity and decreased MDA and NO levels in the testicular tissue compared with the CIS-induced toxicity group (Ilbey et al 2009).…”

Section: Th E Eff Ect Of C Longa and Curcumin On Male Reproductive Smentioning

confidence: 99%

The effects of Curcuma longa and curcumin on reproductive systems

Mohebbati

Anaeigoudari

Khazdair

2017

Endocrine Regulations

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Objective. Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-infl ammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an eff ort on a detailed literature survey concentrated on the protective eff ects of C. longa and curcumin on the reproductive organs activity.Methods. Th e databases such as, PubMed, Web of Science, Google Scholar, Scopus, and IranMedex, were considered. Th e search terms were "testis" or "ovary" and "Curcuma longa", "curcumin", "antioxidant eff ect", "anti-infl ammatory eff ect" and "anti-cancer eff ect".Results. C. longa and curcumin inhibited the production of the tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) and increased the caspases (3, 8 and 9) activities in HL-60 prostate cancer. Furthermore, C. longa and curcumin suppressed the vascular endothelial growth factor (VEGF), phosphorylated signal transducers and activators of the transcription 3 (STAT) and matrix metalloproteinase-9 (MMP-9) in ovarian cancer cell line.Conclusion. C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. C. longa and curcumin have a protective eff ect on the reproductive organs activity such as, anti-infl ammatory, anti-apoptotic, and antioxidant eff ects in normal cells but showed pro-apoptotic eff ects in the malignant cells. Th erefore, diff erent eff ects of C. longa and curcumin are dependent on the doses and the type of cells used in various models studied.

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Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

Abstract: MAPK and NF-kB activation have a significant role in CIS-induced testicular toxicity. CMN has a strong potential for use as a therapeutic adjuvant in CIS gonadotoxicity.

Cited by 169 publications

References 58 publications

Antioxidant effects of curcumin in spinal cord injury in rats

Antioxidant effects of curcumin in spinal cord injury in rats

Tomato pomace powder ameliorated cisplatin-induced microanatomical alterations in brain of Wistar rats

The effects of Curcuma longa and curcumin on reproductive systems

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