Protective effect of Ecklonia cava enzymatic extracts on hydrogen peroxide-induced cell damage

Kim, Kil-Nam; Heo, Soo‐Jin; Song, Choon Bok; Lee, Jehee; Heo, Moon‐Soo; Yeo, In-Kyu; Kang, Kyoung Ah; Hyun, Jin Won; Jeon, You‐Jin

doi:10.1016/j.procbio.2006.06.028

Cited by 83 publications

(34 citation statements)

References 56 publications

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“…An EC extract has recently been used in the United States as a commercial dietary supplement because of its antioxidative activity. It has been reported that EC had bioactive properties that were antioxidative, 27) immuneenhancing, 28) and inhibitory of histamine release 26) and human immunodeficiency virus 1 reverse transcriptase. 29) Previous studies have reported the major constituents of the bioactive properties of EC to be phlorotannins which are found only in brown seaweeds.…”

Section: Discussionmentioning

confidence: 99%

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction fromEcklonia cavaEdible Brown Seaweed

Cho

Han

Kim

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction fromEcklonia cavaEdible Brown Seaweed

Cho

Han

Kim

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…Additionally, E. cava was reported to harbor compounds with various biological activities, including carotenoids, fucoidan, and phlorotannins (Kang et al, 2012). E. cava extracts exhibit various biological functions, including antioxidant, antibacterial, protease inhibitory, immunomodulatory, antiasthmatic, and tyrosinase inhibitory activity (Kim et al, 2006;Kang et al, 2012). However, the antibacterial activity of E. cava against L. monocytogenes has not been reported to date.…”

Section: Disk Diffusion Assaymentioning

confidence: 99%

Synergistic Antibacterial Activity of Ecklonia cava (Phaeophyceae: Laminariales) against Listeria monocytogenes (Bacillales: Listeriaceae)

Nshimiyumukiza¹,

Kang²,

Kim³

et al. 2015

Fisheries and aquatic sciences

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In an effort to discover alternative antimicrobials against Listeria monocytogenes, several marine algae were screened. The methanolic extract of Ecklonia cava exhibited the highest antibacterial activity against L. monocytogenes, with the ethyl acetate (EtOAc) soluble fraction of E. cava methanolic extract having a MIC value of 256 µg/mL and a MBC value of 512 µg/mL. The MIC values of streptomycin in combination with the EtOAc fraction were markedly reduced up to 64-fold, suggesting that the antibacterial activity of the antibiotic was restored when combined with the EtOAc fraction. The interaction between streptomycin and the EtOAc fraction was assessed by fractional inhibitory concentration (FIC) indices. The combination of streptomycin and the EtOAc fraction against L. monocytogenes resulted in ∑FIC min range of 0.141 to 0.266 and ∑FIC max of 0.531 for all strains. The median ∑FIC against L. monocytogenes strains ranged from 0.172 to 0.344. Thus, synergistic ranges of FIC <1 were observed for all combinations of streptomycin and the EtOAc fraction against L. monocytogenes strains. Indeed, the median ∑FIC of streptomycin-EtOAc fraction ranged from 0.172 to 0.344, suggesting a marked synergy.

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“…Our results indicate that 80% EtOH extracts from ECPB fermented for 1 day have efficient antioxidant properties. In addition, previous experiments have shown the H 2 O 2 scavenging ability of enzymatic extracts of E. cava (Kim et al 2006).…”

Section: Discussionmentioning

confidence: 88%

“…Ecklonia cava is a brown alga (Laminariaceae) that is found abundantly in the sub-tidal regions of Jeju Island, South Korea and Japan (Kim et al 2006; with 30,000 t y −1 commercial production. This seaweed is popular in Korea and Japan as a food ingredient and supplement of animal feed (Lee et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…It is well established that brown algae contain polyphenolic compounds with strong antioxidant activity (Heo et al 2009). Furthermore, it has been reported that E. cava has numerous biological activities including antioxidant (Kim et al 2006;Li et al 2009), anticoagulative (Athukorala et al 2006), antiinflammatory (Kim and Bae 2010), and anticancer activity (Kong et al 2009). These beneficial effects have been attributed to its variety of chemical ingredients, including polyphenols.…”

Section: Introductionmentioning

confidence: 99%

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Value-added fermentation of Ecklonia cava processing by-product and its antioxidant effect

et al. 2011

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The interest in the extraction of polyphenolic compounds from plant materials is focused on upgrading of the large amount of by-products coming from food or cosmetics industries from which the press residues have particularly high contents of phenolics. In this study, for value-added use of the brown seaweed Ecklonia cava processing by-product (ECPB), which can be obtained after polyphenolic extraction of E. cava, it was fermented by the yeast Candida utilis and its antioxidant activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, and alkyl radical scavenging using electron spin resonance spectrometer. ECPB was fermented for 1~4 days prior to being extracted with 80% ethanol, and significant differences were observed in extraction yields, total phenolic contents (TPC), and radical scavenging activities with the fermentation time. Extract from the ECPB fermented for 1 day exhibited the highest TPC and also found to be the strongest antioxidant. The 1-day fermented ECPB strongly enhanced cell viability against H 2 O 2 -induced oxidative damage in Vero cell line. This sample also exhibited good protective properties against H 2 O 2 -induced cell apoptosis as was demonstrated by a decreased quantity of sub-G1 hypodiploid cells and decreased apoptotic body formation in the flow cytometry analysis. This study demonstrated that the fermentation elevated functionally important polyphenolic contents of ECPB and resultant antioxidant activities were enhanced. Therefore, the fermentation could offer a tool to further increase the bioactive potential of ECPB.

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Protective effect of Ecklonia cava enzymatic extracts on hydrogen peroxide-induced cell damage

Cited by 83 publications

References 56 publications

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction fromEcklonia cavaEdible Brown Seaweed

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction fromEcklonia cavaEdible Brown Seaweed

Synergistic Antibacterial Activity of Ecklonia cava (Phaeophyceae: Laminariales) against Listeria monocytogenes (Bacillales: Listeriaceae)

Value-added fermentation of Ecklonia cava processing by-product and its antioxidant effect

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