Protective effect of Emilia sonchifolia on azaserine-induced pancreatic dysplasia

Sophia, Dominic; Ragavendran, Paramasivam; Raj, Chinthamony Arul; Gopalakrishnan, Vishrawas

doi:10.1016/j.jacme.2014.02.003

Cited by 4 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ALP values of rats in azaserine + paclitaxel group showed significant (p<0.05) increase when compared to control and azaserine groups. This was in conformation with the findings of Sophia et al (2014) who reported that the elevation could potentially be attributed to the release of these enzymes from the cytoplasm into the blood circulation after rupture of the plasma membrane and cellular damage of the liver. Also,liver played an important role in the modulation of the process of carcinogenesis, as it was the primary site for the biotransformation of xenobiotics including carcinogens.…”

Section: Discussionsupporting

confidence: 91%

“…Significant alterations in the ALT, AST and ALP levels were observed when male wistar rats were treated with azaserine (Sophia et al, 2014;Prajapati et al, 2015Prajapati et al, , 2016. Mardani et al (2014) reported no significant changes in the serum biochemical parameters upon administration of M. charantia fruit extracts along with the diet up to a level of 2 per cent of the diet.…”

Section: Annals Ofmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Rajamohan¹,

Sridhar²,

Hemalatha³

et al. 2018

View full text Add to dashboard Cite

The present investigation was carried out to study the effect of Momordica charantia L. (Bitter gourd) on serum biochemical parameters in male wistar rats induced with pancreatic atypical acinar cell tumor. Ninety six male wistar rats were randomized into four groups [control group, (i), azaserine group (ii), azaserine + paclitaxel (iii) and azaserine + Momordica charantia (MC) (iv) group] each comprising of 24 rats. Male wistar rats of group (ii, iii and iv) were administered with azaserine @ 30 mg per kg BW intraperitoneally (i.p.) on 21 st day of age. Paclitaxel was administered to the azaserine + paclitaxel group (iii) @ 33 mg/kg BW intraperitoneally for 6 weeks after 8 weeks post initiation of tumor and aqueous extract of Momordica charantia @ 0.34 ml/rat was administered as oral gavage for 6 weeks after 8 weeks post initiation of tumor to azaserine + Momordica charantia group (iii). The blood was collected for estimation of serum biochemical parameters at the end of 24 th week. Significant alterations in ALT, ALP, triglyceride, cholesterol, lipase and amylase levels were observed among the groups ii, iii and iv. The alterations were compared with the control and azaserine + paclitaxel group which revealed the high level of protective effect of aqueous extract of Momordica charantia, on the serum biochemical alterations.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Annals Ofmentioning

confidence: 99%

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Rajamohan¹,

Sridhar²,

Hemalatha³

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Sophia et al 46 reported the effect of n-hexane extract of E. sonchifolia on azaserine (O-diazoacetyl-L-serine)induced pancreatic dysplasia in rats. Results of the study revealed a significant decrease of pancreatic and hepatic enzymatic antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), glutathione peroxidase (GPx) and non-enzymatic antioxidants like vitamin C, glutathione (GSH) content, and a significant increase in pancreatic serum amylase and lipase, and levels of hepatic marker enzymes viz.…”

Section: Anticancer Activitymentioning

confidence: 99%

Traditional Uses, Phytochemical and Pharmacological Aspects of Emilia Sonchifolia (L.) Dc

Dash¹,

Abdullah²,

Yahaya.³

2015

Int. J. Res. Ayurveda Pharm.

View full text Add to dashboard Cite

Emilia sonchifolia (L.) DC (Family: Asteraceae), commonly known as 'lilac tasselflower' is an important edible medicinal plant found to be used as one of the popular ingredients of traditional vegetable salads in Malaysia, Bangladesh and India. In addition to its use as a vegetable, the plant is documented in ethnomedicine to possess several medicinal benefits in treating night blindness, epilepsy, fever and inflammatory diseases, malaria, asthma, liver diseases, eye inflammation, influenza, burns and breast abscesses. The pharmacological studies have shown that the plant possesses numerous notable biological activities such as antimicrobial, analgesic, antiinflammatory, antioxidant, anticancer, antidiabetic, hepatoprotective, antianxiety, anticataract and anticonvulsant activities. A few phytoconstituents have been isolated from the plant. The plant is rich with flavonoids. Presence of pyrrolizidine alkaloids have been reported in the plant. Pyrrolizidine alkaloids are considered to be hepatotoxic and therefore, the use of the plant either as a food or in ethnomedicine need to be restricted. With the availability of primary investigations, further investigations are recommended to study the toxicity of the plant in detail before rationalizing its use as a health food.

show abstract

Survival of silk worm, Bombyx mori in azaserine induced oxidative stress

Mandyam.D.

Subramanyam

2020

Comparative Biochemistry and Physiology Part C: Toxicology &

View full text Add to dashboard Cite

Protective effect of Emilia sonchifolia on azaserine-induced pancreatic dysplasia

Cited by 4 publications

References 25 publications

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Traditional Uses, Phytochemical and Pharmacological Aspects of Emilia Sonchifolia (L.) Dc

Survival of silk worm, Bombyx mori in azaserine induced oxidative stress

Contact Info

Product

Resources

About