Protective Effect of Ethanolic Extract Tempuyung Leaf (Sonchus arvensis L.) in Gentamicin-induced Acute Tubular Necrosis on Wistar Rats

Imelda, Imelda; Achadiyani, Achadiyani; Sekarwana, Nanan

doi:10.14499/indonesianjpharm29iss2pp86

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…Decreased serum urea and creatinine levels revealed an improvement in kidney function of the test animals [30][31][32]. These findings are in line with the report of Imelda et al showed that Sonchus arvensis L. 100 and 200 mg/kg b.w reduced serum urea and creatinine levels after administration of Sonchus arvensis L. extract and gentamicin for ten days, simultaneously [10,33].…”

Section: Discussionsupporting

confidence: 89%

“…Sonchus arvensis L. has been shown to have a diuretic effect in rats that have induced hyperuricemia [9]. Sonchus arvensis L. 100 mg/kg b.w have been shown to decrease serum creatinine levels in rat kidney failure induced by gentamicin [10]. It also has antioxidant activity against 2,2diphenyl-1-picrylhydrazyl (DPPH) free radicals, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ABTS, OH, and superoxide [11].…”

Section: Introductionmentioning

confidence: 99%

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Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Suliska¹,

Praviska²,

Kurniati³

et al. 2021

jrp

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Kidney failure is characterized by a decrease in the glomerular filtration rate, albuminuria, increased serum creatinine and blood urea nitrogen levels, abnormalities in kidney histology, and electrolyte disturbances. Sonchus arvensis L. contain high antioxidants such as flavonoids, glycosides, alkaloids, steroids/triterpenoids, tannins, saponins, and quinones, so it has the potential to improve kidney function. Twenty-five male Wistar albino rats were divided into five groups: negative control, positive control (induction of kidney failure), and three test groups which were administered an ethanol extract of Sonchus arvensis L. leaves of 50, 100, and 150 mg/kg b.w doses, respectively. Rats kidney failure model were using gentamycin 100 mg/kg b.w. and piroxicam, 3.6 mg/kg b.w. induction. Sonchus arvensis L. extracts were then administered for four weeks. The parameters for nephroprotective of Sonchus arvensis L. were urea and serum creatinine levels, urine volume, kidney organ histology, TBARS, and catalase activity. There was an improvement in kidney function as all Sonchus arvensis L. dosage levels were characterized by a significant decrease in serum urea levels (25-30%) and serum creatinine (16-23%), as well as significantly increased urine volume (83-167%) in the third week of therapy. At the end of treatment, there was a decrease in the TBARS levels (7-17%) and increased catalase activity (41-62%), significantly in all the treatment groups. The best effect was seen when using the 150 mg/kg b.w. the dose of Sonchus arvensis L. extract.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Suliska¹,

Praviska²,

Kurniati³

et al. 2021

jrp

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“…Furthermore, blood was collected from the experimental mice to determine the nephroprotective, hepatoprotective, and immunomodulatory activities after 7 days of treatment with ethyl acetate extract of S. arvensis L. Many studies have reported that S. arvensis L. extracts exhibited antioxidant [25], hepatoprotective [13], nephroprotective [42], and immunomodulatory [43] activities. The present study was conducted to assess the effect of an ethyl acetate extract of S. arvensis L. against P. berghei infection in mice.…”

Section: Discussionmentioning

confidence: 99%

“…P. berghei parasites will infect erythrocytes and activate cytokines of phagocytic cells and endothelial cells to produce TNF-α, IL-10, IFN-γ, and free radicals (ROI, ROS, and NO). Free Wahyuni et al BMC Complementary Medicine and Therapies (2023) 23:47 radicals are molecules with one unpaired electron in their outer orbit which makes the molecule unstable [42]. Free radicals can cause oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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In vitro and in vivo antiplasmodial activities of leaf extracts from Sonchus arvensis L.

Wahyuni

Wacharasindhu

Bankeeree

et al. 2023

BMC Complement Med Ther

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Background Malaria continues to be a global problem due to the limited efficacy of current drugs and the natural products are a potential source for discovering new antimalarial agents. Therefore, the aims of this study were to investigate phytochemical properties, cytotoxic effect, antioxidant, and antiplasmodial activities of Sonchus arvensis L. leaf extracts both in vitro and in vivo. Methods The extracts from S. arvensis L. leaf were prepared by successive maceration with n-hexane, ethyl acetate, and ethanol, and then subjected to quantitative phytochemical analysis using standard methods. The antimalarial activities of crude extracts were tested in vitro against Plasmodium falciparum 3D7 strain while the Peter's 4-day suppressive test model with P. berghei-infected mice was used to evaluate the in vivo antiplasmodial, hepatoprotective, nephroprotective, and immunomodulatory activities. The cytotoxic tests were also carried out using human hepatic cell lines in [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Result The n-hexane, ethyl acetate, and ethanolic extracts of S. arvensis L. leaf exhibited good in vitro antiplasmodial activity with IC50 values 5.119 ± 3.27, 2.916 ± 2.34, and 8.026 ± 1.23 μg/mL, respectively. Each of the extracts also exhibited high antioxidant with low cytotoxic effects. Furthermore, the ethyl acetate extract showed in vivo antiplasmodial activity with ED50 = 46.31 ± 9.36 mg/kg body weight, as well as hepatoprotective, nephroprotective, and immunomodulatory activities in mice infected with P. berghei. Conclusion This study highlights the antiplasmodial activities of S. arvensis L. leaf ethyl acetate extract against P. falciparum and P. berghei as well as the antioxidant, nephroprotective, hepatoprotective, and immunomodulatory activities with low toxicity. These results indicate the potential of Sonchus arvensis L. to be developed into a new antimalarial drug candidate. However, the compounds and transmission-blocking strategies for malaria control of S. arvensis L. extracts are essential for further study.

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Anredera cordifolia (Ten.) Steenis and Sonchus arvensis L. Inhibit Gentamicin-induced Nephrotoxicity

Suliska

Kurniati

Sukandar

2021

Journal of Reports in Pharmaceutical Sciences

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Introduction: Anredera cordifolia (Ten.) v Steenis and Sonchus arvensis L. have been used traditionally to treat many diseases such as inflammation, hypercholesterolemia, and kidney stones. This study investigated the renoprotective effect of the best combination of A. cordifolia (Ten.) Steenis and S. arvensis L. against gentamicin-induced nephrotoxicity in rats reduced the urinary N-acetyl beta-D-glucosaminidase (NAGase) specific marker. Materials and Methods: This study used male Wistar rats, weighing 200–300 g. The experiment consisted of a negative control group, a positive control group, A. cordifolia 100 mg/kg (body weight) b.w. group (AE), S. arvensis 100 mg/kg b.w. group (SE), A. cordifolia 50 mg/kg b.w. + S. arvensis 50 mg/kg b.w. (AE50 + SE50), A. cordifolia 100 mg/kg b.w. + S. arvensis 100 mg/kg b.w. (AE100 + SE100), A. cordifolia 75 mg/kg b.w. + S. arvensis 25 mg/kg b.w. (AE75 + SE25), and A. cordifolia 25 mg/kg b.w. + S. arvensis 75 mg/kg b.w. (AE25 + SE75). All groups were given the extract according to the group for 14 days orally. On day 15, all groups except the negative control group induced renal failure by administering gentamicin 100 mg/kg b.w. for 8 days along with the extract. On day 22, the evaluation was carried out by measuring urea, creatinine, and NAGase. Results: All treatment groups showed significantly decreased levels of creatinine and urea in serum and urinary NAGase when compared with the positive control group (P < 0.05). The AE75 + SE25 group showed the smallest elevated levels of creatinine (14, 36%) and urea (17.4%) in serum and urinary NAGase (29.4%) when compared with the positive control group (P < 0.05). Conclusion: The combination of A. cordifolia 75 mg/kg b.w. and S. arvensis 25 mg/kg b.w. extract showed a better nephroprotective effect in decreasing the NAGase as the early biomarker in kidney failure.

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Protective Effect of Ethanolic Extract Tempuyung Leaf (Sonchus arvensis L.) in Gentamicin-induced Acute Tubular Necrosis on Wistar Rats

Cited by 5 publications

References 6 publications

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

In vitro and in vivo antiplasmodial activities of leaf extracts from Sonchus arvensis L.

Anredera cordifolia (Ten.) Steenis and Sonchus arvensis L. Inhibit Gentamicin-induced Nephrotoxicity

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