Protective effect of Ginkgo extract on rat brain with transient middle cerebral artery occlusion

Zhang, W.R.; Hayashi, Takeshi; Kitagawa, Hisashi; Sasaki, Chihoko; Sakai, Kenichi; Warita, Hitoshi; Wang, J.M.; Shiro, Yoshihiko; Uchida, Masao; Abe, Kōji

doi:10.1080/01616412.2000.11740713

Cited by 63 publications

(34 citation statements)

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“…Ginkgo biloba may be of great value in cases of age-related mental dysfunction (Kleijnen & Knipschild, 1992;Zhang et al, 2000;Maclennan et al, 2002) including senility, dementia (Le Bars et al, 1997), and diminished memory (Keenedy et al, 2000). Numerous preclinical studies have shown the neuroprotective effects of the standard extract EGb761 and support the notion that it may be effective in the treatment and prevention of neurodegenerative disorders such as Alzheimer's disease 2 .…”

Section: Introductionmentioning

confidence: 97%

Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids

Santos

Souza

Conde-Garcia

et al. 2014

Rev. bras. plantas med.

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Electrocardiographic effects produced by Ginkgo biloba extract (EGb) and by ginkgolides A (GA) and B (GB), and bilobalide (BB) were investigated in guinea pig heart mounted in Langendorff apparatus (Tyrode, 34 ± 0.1 o C, 95% O 2 , 5% CO 2 ). Electrocardiographic parameters were evaluated in the conditions: 1) control with Tyrode and DMSO, 2) EGb (n=4), GA (n=5), GB (n=5) or BB (n=6), and 3) washout. The results showed that 0.1 and 1.0 mg/ml of EGb do not change the electrocardiographic parameters. However, 10 mg/ml of EGb increased the PR interval (PRi) at 21% (p<0.001). This increase was also observed for 50 mM GA (20%, p<0.001) and 70 mM BB (13%, p<0.001), which indicates Ca 2+ channel block. However, the 50 mM GB reduced the PRi at 11 % (p<0.001). The GA (23%, p<0.001), GB (16%, p<0.001), and BB (40%, p<0.001) reduced the QT interval (QTi), which suggests the activation of the potassium channel. However, EGb increased QTi (6%, p<0.001). The EGb (28%, p<0.05) and GB (13%, p<0.05) reduced the heart rate. Atrioventricular (AV) block was observed with EGb, GA, and BB. We can conclude that EGb and its terpenoids alter the ECG parameters inducing AV block, which indicates possible arrhythmogenic potential.Keywords: Ginkgo biloba, ginkgolide A, ginkgolide B, bilobalide, heart. RESUMO. Perfil eletrocardiográfico do coração de cobaia submetido ao extrato de Ginkgo biloba e seus terpenóides. Os efeitos eletrocardiográficos produzidos pelo extrato de Ginkgo biloba (EGb) e gingkolídeos A (GA) e B (GB), e bilobalide (BB) foram investigados em coração de cobaia montado sistema de Langendorff (Tyrode, 34 ± 0.1 o C, 95% O 2 , 5% CO 2 ). Os parâmetros do ECG foram avaliados nas condições: 1) Tyrode e DMSO, 2) EGb (n=4), GA (n=5), GB (n=5) ou BB (n=6) diluídos em DMSO e 3) washout. Os resultados demonstram que 0,1 e 1,0 mg/ mL de EGb não alteraram os parâmetros eletrocardiográficos. Entretanto, 10 mg/ml de EGb aumentaram o intervalo PR (PRi) em 21% (p<0.001). Esse aumento também foi observado com GA a 50µM (20%, p<0,001) e BB a 70 mM (13%, p<0,001) indicando bloqueio de canais de cálcio. Por outro lado, GB reduziu o PRi (11%, p<0,001). O intervalo QT (QTi) foi reduzido por GA (23%, p<0,001), GB (16%, p<0,001) e BB (40%, p < 0.001) sugerindo uma ativação de canais de potássio. Entretanto, EGb aumentou o QTi (6%, p<0.001). A frequência cardíaca foi reduzida por EGb (28%, p<0.05) e GB (13%, p<0.05). Bloqueios átrio-ventriculares (BAV) foram observados com EGb, GA e BB. Podemos concluir que EGb e os terpenos alteram parâmetros eletrocardiográficos induzindo BAV e demonstrando possível potencial arritmogênico. Palavras-chave:Ginkgo biloba, ginkgolídeo A, ginkgolídeo B, bilobalide, coração.

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Section: Introductionmentioning

confidence: 97%

Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids

Santos

Souza

Conde-Garcia

et al. 2014

Rev. bras. plantas med.

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“…GkbE has been used in the cardiac injury, infarction, brain infarction, ischemic reperfusion induced injury. 2,7 Efficacy against the ethanol induced gastric mucosal injury, 8 and chemical induced oxidative stress and liver fibrosis have been reported. tetrachloride injury was revisited.…”

Section: Introductionmentioning

confidence: 99%

CCl4 INDUCED LIVER INJURY; AQUEOUS EXTRACT OF GINKGO BILOBA (GKBE) AMELIORATES CYTOPLASMIC AND MITOCHONDRIAL ENZYMES

Naz

Irshad

Mawani

2017

TPMJ

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“…The extract and its ingredients, especially ginkgolides, also exhibit an antagonistic effect on platelet-activating factor 23) . These effects of the extract are responsible, in part, for its protective effects on tissue abnormalities including myocardial ischemia-reperfusion injury 24) and ischemic brain damage 25,26) , being beneficial to patients with cardiovascular, cerebrovascular, and neurological disorders 27,28) . A previous study showed that Ginkgo Biloba extracts inhibit serum-induced proliferation of rat vascular SMCs, and prevent intimal hyperplasia in balloon-injured abdominal aorta in rabbits fed with high-cholesterol diet 29) ; however, it is unclear whether these inhibitory effects are ascribable only to the antioxidative effects or antagonistic effects on platelet-activating factor.…”

Section: Introductionmentioning

confidence: 99%

Suppression of Oxidized LDL-Induced PDGF Receptor .BETA. Activation by Ginkgo Biloba Extract Reduces MMP-1 Production in Coronary Smooth Muscle Cells

Akiba

Yamaguchi

Kumazawa

et al. 2007

JAT

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Aim: An extract of Ginkgo Biloba L. was shown to have preventive effects on cardiovascular disorders, but the molecular mechanisms of its actions remain to be elucidated. Since matrix metalloproteinases (MMPs) are implicated in the rupture of atherosclerotic plaques and the subsequent occurrence of acute coronary syndrome, we examined the effects of a leaf extract (Ginkgolon-24) on the production of MMP-1 in human coronary smooth muscle cells stimulated with oxidized low-density lipoprotein (oxLDL) and 4-hydroxynonenal, which are factors proposed to play a pivotal role in atherogenesis. Methods: The production of MMP-1 and phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 were estimated by immunoblotting. The tyrosine-phosphorylated form of platelet-derived growth factor receptor (PDGFR-) was analyzed by immunoprecipitation of the receptor followed by immunoblotting.

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Protective effect of Ginkgo extract on rat brain with transient middle cerebral artery occlusion

Cited by 63 publications

References 0 publications

Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids

Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids

CCl4 INDUCED LIVER INJURY; AQUEOUS EXTRACT OF GINKGO BILOBA (GKBE) AMELIORATES CYTOPLASMIC AND MITOCHONDRIAL ENZYMES

Suppression of Oxidized LDL-Induced PDGF Receptor .BETA. Activation by Ginkgo Biloba Extract Reduces MMP-1 Production in Coronary Smooth Muscle Cells

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