Protective effect of<i>Canavalia gladiata</i>(sword bean) fruit extracts and its flavanoidal contents, against azathioprine-induced toxicity in hepatocytes of albino rats

Kumar, C. Hari; Reddy, Y. V. R.

doi:10.1080/02772248.2014.950805

Cited by 13 publications

(7 citation statements)

References 3 publications

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“…The nutritional components of dried soybeans and pods consist of general components such as protein, fat, and moisture, as well as various vitamins and minerals, and the contents are shown in Supplementary Materials Table S1 . Recently, various functional activities of SB such as anti-obesity [ 24 ], antioxidant [ 25 ], anti-inflammatory [ 26 ], hematopoietic expansion improvement [ 27 ], hepatoprotective, and anti-angiogenic effects [ 28 ] have been reported. However, scientific research using SB pods (SBP) has not been conducted except for anti-inflammation and anti-obesity, and the mechanism is not yet clearly defined.…”

Section: Introductionmentioning

confidence: 99%

Sword Bean (Canavalia gladiata) Pod Exerts Anti-Allergic and Anti-Inflammatory Effects through Modulation of Th1/Th2 Cell Differentiation

Hwang

et al. 2022

Nutrients

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Allergy is an immunoglobulin E (IgE)-mediated process, and its incidence and prevalence have increased worldwide in recent years. Therapeutic agents for allergic diseases are continuously being developed, but side effects follow when used for a long-term use. Therefore, treatments based on natural products that are safe for the body are urgently required. Sword bean (Canavalia gladiata) pod (SBP) has been traditionally used to treat inflammatory diseases, but there is still no scientific basis for its anti-allergic effect. Accordingly, this study investigates the anti-allergic effect and its mechanism of SBP in vitro and in vivo. SBP reduced the nitric oxide production and decreased mRNA and protein expression of inflammatory mediates (inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)), and inhibited the phosphorylation of nuclear factor kappa B (NF-κB), a major signaling molecule in the inflammatory response. Additionally, SBP extract treatment inhibited phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling activity to further inhibit degranulation and allergy mediator generation and control the balance of Th1/Th2 cells, which can induce an allergic reaction when disrupted. Furthermore, the SBP extract exhibited anti-allergic effects in anti-dinitrophenyl IgE-induced RBL-2H3 cells and ovalbumin-treated mice. These findings have potential clinical implications for the treatment as well as prevention of allergic diseases.

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Section: Introductionmentioning

confidence: 99%

Sword Bean (Canavalia gladiata) Pod Exerts Anti-Allergic and Anti-Inflammatory Effects through Modulation of Th1/Th2 Cell Differentiation

Hwang

et al. 2022

Nutrients

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“…It is rich in different nutrients, such as carbohydrates, proteins, vitamins and minerals (Ekanayake et al ., ). Furthermore, recent studies find that it possesses biological functions, such as anti‐inflammatory, haematopoietic improving, hepatoprotective and anti‐angiogenic activities (Jeon et al ., ; Kim et al ., ,b; Kumar & Reddy, ). Therefore, the sword bean has great nutritional and medicinal potential.…”

Section: Introductionmentioning

confidence: 99%

Sword bean (Canavalia gladiata) as a source of antioxidant phenolics

Gan

Lui

Corke

2015

Int J of Food Sci Tech

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Summary Sword beans (Canavalia gladiata) have been used as grain legumes and medicinal plants in China for thousands of years. To explore new natural antioxidant sources, the antioxidant capacity and phenolic composition in the soluble and bound fractions of three sword bean genotypes were evaluated in vitro. The red and black sword beans were found to have antioxidant capacity compared to the white sword bean, and this was attributed to their red and black bean coats, which possessed extremely high phenolic content. Gallic acid and its derivatives, such as methyl gallate, digalloyl hexoside and digallic acid, were the main phenolic compounds in the coats of red and black sword beans. Therefore, the red and black sword beans, especially their bean coats, are good sources of antioxidant phenolics and may have potential health benefits.

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“…Black and red of C. gladiata are excellent antioxidant phenolic sources (Gan et al 2016). In a rat experiment, using seed extract of C. gladiata with doses of 100 and 200 mg/kg can decrease AZP-induced hepatotoxicity (Kumar and Reddy 2014). C. ensiformis has been tested containing the neutral lipids of 2.21% of whole seeds, as well as the fatty acid, i.e., palmitic (15%), oleic (54%), linolenic (8%), and linoleic (7%) (Gaydou et al 1992).…”

Section: Seedmentioning

confidence: 99%

Local knowledge of plant-based nutrition sources from forgotten foods in Datengan Village, East Java, Indonesia

Afrianto¹,

Tamnge

Hidayatullah³

et al. 2021

Asian J Ethnobiol

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Abstract. Afrianto WF, Tamnge F, Hidayatullah T, Hasanah LN. 2021. Local knowledge of plant-based nutrition sources from forgotten foods in Datengan Village, East Java, Indonesia. Asian J Ethnobiol 4: 53-64. Plant-based food has benefits for health and the environment. Finding adequate plant-based nutrition sources can be found by exploring local knowledge. Here, forgotten foods mean two definitions that (i) those foods were consumed by the community before, but over time it is forgotten in the daily diet, and (ii) unusually consumed by the community outside, but it still is or over-consumed by the community. This study aimed to identify the plant-based nutrition sources in Datengan Village. The study was conducted in the Datengan Village, Grogol Sub-district, Kediri District, East Java Province, Indonesia. Ethnobotany approach through qualitative research (i.e., observation, semi-structured interview, and participant observation) were used to explore the plant-based nutrient sources from forgotten foods in Datengan Village. The results showed forgotten foods in Datengan Village, i.e., fermented foods, mushrooms, by-products, and plant rich-nutrition. There were 26 plant-rich-nutrition, two mushrooms, two fermented foods, and six by-product foods. This investigation is still a preliminary study. 14 handling, processing, and serving methods were used based on the interview. This plant-based nutrition source diversity can be an alternative to fulfill nutrient requirements for the community of Datengan Village and the community of outside areas.

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Protective effect ofCanavalia gladiata(sword bean) fruit extracts and its flavanoidal contents, against azathioprine-induced toxicity in hepatocytes of albino rats

Cited by 13 publications

References 3 publications

Sword Bean (Canavalia gladiata) Pod Exerts Anti-Allergic and Anti-Inflammatory Effects through Modulation of Th1/Th2 Cell Differentiation

Sword Bean (Canavalia gladiata) Pod Exerts Anti-Allergic and Anti-Inflammatory Effects through Modulation of Th1/Th2 Cell Differentiation

Sword bean (Canavalia gladiata) as a source of antioxidant phenolics

Local knowledge of plant-based nutrition sources from forgotten foods in Datengan Village, East Java, Indonesia

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