Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction

Abstract

Inf may partially prevent mtx-induced hepatic damage in rats. However, the combined usage of mtx and inf increases arginase and CPS-1 enzyme activities and at the same time blocks TNF-α. This combination especially in cancer patients may lead to cancer cell invasion and metastasis.

The use of 99mTc-phytate for assessment the protective effect of vitamin E against hepatotoxicity induced by methotrexat in rat

“…Both techniques proved that the reticuloendothelial cells were damaged by ionizing radiation, which might result in malfunction of the Kupffer cells and or a decrease in their number [28]. Histological findings of MTX-induced hepatotoxicity are including macrovesicular steatosis, hepatocellular necrosis and inflammation, edema, fibrosis, morphological abnormalities and development of cirrhosis [29][30][31]. Chemotherapeutic agents caused drug induced acute hepatitis and hepatomegaly, decreased liver enhancement and widening of periportal space due to edema which are nonspecific imaging findings of acute hepatitis [32].…”

Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

“…3,4 Methotrexate is used to treat many different types of cancer (colorectal, breast, and pancreatic cancers) and inflammatory diseases (rheumatoid arthritis − RA, psoriatic arthritis, systemic lupus erythematosus, and dermatomyositis). [1][2][3][4][5] Nevertheless, its use is associated with side effects such as fibrosis affecting the liver, lung, and other organs. 1,2,5 Acute intense MTX side effects are dose-dependent.…”

“…[1][2][3][4][5] Nevertheless, its use is associated with side effects such as fibrosis affecting the liver, lung, and other organs. 1,2,5 Acute intense MTX side effects are dose-dependent. Bone marrow suppression, gastrointestinal upsets or ulcers, and liver fibrosis are well-known acute or common side effects of MTX therapy.…”

“…It has been proposed in recent studies that MTX has a cytotoxic effect in reducing intracellular tetrahydrofolate, but the mechanism of MTX-induced toxicity is not well known. 1,2,[4][5][6][7][8][9][10][11] Methotrexate has been used in the treatment of pancreatic cancer, but there has been no research into its side effects on the pancreas, an organ which is relatively sensitive to various toxic substances and drugs. High-dose substances, causing oxidative stress, have been reported to have a toxic effect on the pancreas.…”

Infliximab Modulates Cisplatin-Induced Hepatotoxicity in Rats

“…Ib ameliorates carbon tetrachloride-induced liver injury by decreasing the production of transforming growth factor beta and interleukin 1 beta (IL-1β) and by regulating purine metabolism (8). Ib also decreases liver injury by decreasing the production of IL-1β and TNF-α that typically results from methotrexate-induced hepatotoxicity, and by decreasing the formation of peroxynitrite radicals by preventing the formation of excess nitric oxide (7).…”