Protective Effect of Lignophenol Derivative from Beech (<i>Fagus crenata</i> Blume) on Copper‐ and Zinc‐Mediated Cell Death in PC12 Cells

Sato, Shin; Fujita, Shuzo; Funaoka, Masamitsu; Komori, Miyako; Kurasaki, Masaaki

doi:10.1111/j.1742-7843.2006.pto_535.x

Cited by 14 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, lignocresol, a derivative from bamboo, demonstrated anti-apoptotic effects against hydrogen peroxide in human neuroblastoma cells in which caspase-3 activation was inhibited (Akao et al, 2004). 2-Methxoy-p-cresol is generally believed to be the anti-apoptotic constituent of pyrolyzates, and lignophenol is a p-cresol derivative that exhibits high phenolic function and antioxidant properties in vitro (Sato et al, 2006). It has been assumed that pyrolyzates may reduce neuronal damage by blocking Ca 2+ influx via NMDA receptors, or inhibiting apoptotic factors such as hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 98%

Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation

Hong

Jung

Lee

et al. 2010

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation

Hong

Jung

Lee

et al. 2010

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Similar results were obtained by many other researchers. Sato et al (2006) found that LPs had an anti-apoptotic effect on pheochromocytoma (PC12) cells treated with an excessive amount of Cu and Zn, which were highly associated with ROS generation and oxidative cell injury.…”

Section: Lignin-based Polymers/lignophenolsmentioning

confidence: 99%

“…Lignophenols (LPs) are lignin-derived macromolecules produced experimentally from raw biomass by phase-separation systems, in which cellulose and hemicellulose of lignocellulosic are converted into hydrolyzed carbohydrates while lignin is converted into LPs (Sato et al, 2006;Lochab et al, 2014). Under hydrothermal conditions, these lignin-based polymers can be further converted into monophenols (e.g., phenol, catechol, syringol, and cresol) (Lochab et al, 2014).…”

Section: Lignin-based Polymers/lignophenolsmentioning

confidence: 99%

A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects

et al. 2022

View full text Add to dashboard Cite

Lignin is identified as a promising candidate in renewable energy and bioproduct manufacturing due to its high abundance, polymeric structure, and biochemical properties of monomers. Thus, emerging opportunities exist in generating high-value small molecules from lignin through depolymerization. This review aims at providing an overview of the major technologies of lignin depolymerization. The feasibility of large-scale implementation of these technologies, including thermal, biological, and chemical depolymerizations, are discussed in relation to potential industrial applications. Lignin as a renewable alternative to petroleum-based chemicals has been well documented. This review attempts to emphasize potential applications of lignin-derived monomers and their derivatives as bioactives in food, natural health product, and pharmaceutical sectors. The critical review of the prospects and challenges of lignin-derived bioproducts reveals that the advancement of research and development is required to explore the applications of depolymerization of lignins to their full potential.

show abstract

“…Recently, an LPs from bamboo has been reported to prevent hydrogen peroxide‐induced cell death in vitro [5]. We have also reported the protective effect of LPs from Beech ( Fagus crenata Blume) on copper‐ and zinc‐mediated cell death in rat pheochromocytoma (PC12) cells [6]. However, to the best of our knowledge, no previous study has examined the physiological effects of LPs on lipid metabolism.…”

mentioning

confidence: 99%

Lignophenols Decrease Oleate‐Induced Apolipoprotein‐B Secretion in HepG2 Cells

Norikura

Mukai

Fujita

et al. 2010

Basic Clin Pharma Tox

Self Cite

View full text Add to dashboard Cite

Lignin is one of the components in the plant cell wall, after cellulose, making up 20-30% of the global plant biomass. Lignophenols (LPs) are derivatives of lignin with high phenolic function and antioxidant properties. However, their medicinal property is not well characterised. Apolipoprotein-B (apo-B) is an essential component in very low-density lipoprotein, and high levels of serum apolipoprotein-B (apo-B) are a major factor for coronary heart disease. In this study, we examined the effect of lignophenols on apo-B secretion in HepG2 cells. HepG2 cells were treated with varying concentrations of LPs and 0.8 mM sodium oleate. LPs decreased oleate-induced apo-B secretion in a dose-dependent manner. LPs also decreased oleate-induced microsomal triglyceride transfer protein (MTTP) mRNA expression and cellular total cholesterol, suggesting that lipid bioavailability and lipidation of lipoprotein are likely involved in the decreased secretion of apo-B. Furthermore, LPs decreased oleate-induced mature sterol regulatory element binding protein 2 (SREBP-2), a transcription factor that activates cholesterol biosynthesis. This is the first study to show that LPs can decrease oleate-induced apo-B secretion in HepG2 cells. The modulations of MTTP mRNA expression, cellular total cholesterol metabolism and mature SREBP-2 expression may be important factors in the regulation of apo-B secretion by LPs.Coronary heart disease is a leading cause of death. High prevalence and death rate have spurred the search for novel strategies to prevent coronary heart disease. Apolipoprotein-B (apo-B) is an essential component in very low-density lipoprotein, and its blood level is positively correlated with the incidence of coronary heart disease and atherosclerosis [1]. To meet the public demand for primary prevention of coronary heart disease, medicinal substances that control the rate of apo-B secretion are of great interest.Lignin constitutes 20-30% of woody plant cell walls. Following cellulose, lignin is the second most abundant biopolymer on earth [2]. An original reaction system, a phase-separation system, was developed for the production of lignophenols (LPs) from native lignin [3]. Although LPs have been reported to possess highly phenolic functions, high stability and antioxidative properties in vitro [4], their medicinal properties have remained unclear. Recently, an LPs from bamboo has been reported to prevent hydrogen peroxideinduced cell death in vitro [5]. We have also reported the protective effect of LPs from Beech (Fagus crenata Blume) on copper-and zinc-mediated cell death in rat pheochromocytoma (PC12) cells [6]. However, to the best of our knowledge, no previous study has examined the physiological effects of LPs on lipid metabolism.Several antioxidative polyphenols such as epigallocatechin gallate [7], quercetin [8] and curcumin [9] have been reported to moderately decrease apo-B secretion. Since LPs have also been reported to possess high phenolic function and antioxidant properties in vitro [4], we invest...

show abstract

Protective Effect of Lignophenol Derivative from Beech (Fagus crenata Blume) on Copper‐ and Zinc‐Mediated Cell Death in PC12 Cells

Cited by 14 publications

References 37 publications

Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation

Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation

A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects

Lignophenols Decrease Oleate‐Induced Apolipoprotein‐B Secretion in HepG2 Cells

Contact Info

Product

Resources

About