Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins and antioxidants

Pimple, Bhushan; Kadam, Prasad V.; Patil, M. J.

doi:10.1016/s1995-7645(12)60126-6

Cited by 21 publications

(10 citation statements)

References 17 publications

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“…No autonomic or behavioral changes were detected during first 24 h. At the end of study no mortality was reported in animals even after 14 days of observation (Pimple et al, 2012). …”

Section: Toxicity Studiesmentioning

confidence: 90%

“…In a study performed by Pimple et al (2012), methanolic and aqueous extracts were safe in Swiss albino mice up to the dose of 2,000 mg/kg p.o. No autonomic or behavioral changes were detected during first 24 h. At the end of study no mortality was reported in animals even after 14 days of observation (Pimple et al, 2012).…”

Section: Toxicity Studiesmentioning

confidence: 99%

“…The aqueous extract was less effective than methanolic extract in altering delayed healing of gastric ulcer in diabetic rats. In addition, methanolic extract exhibited dose-dependent glucose lowering and mucosal defensive action (Pimple et al, 2012). …”

Section: Pharmacological Activity Of Luffa Acutangulamentioning

confidence: 99%

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Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Shendge

Belemkar

2018

Front. Pharmacol.

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Luffa acutangula (Cucurbitaceae), a perennial plant grows mainly in India, Southeast Asia, China, Japan, Egypt, and other parts of Africa, it is widely used in the traditional Indian medicinal system to treat various health conditions. The plant has been used in jaundice, diabetes, hemorrhoids, dysentery, headache, ringworm infection, and leprosy. More than 50 chemical compounds have been isolated from a plant which mainly comprises flavonoids, anthraquinones, proteins, fatty acids, saponin triterpene, volatile components, and other phytoconstituents. Crude extract of plant and its isolated compounds possess broad pharmacological activities such as antidiabetic, hepatoprotective, antiulcer, anticancer, immunomodulatory, antihyperlipidemic, antioxidant, antimicrobial, CNS depressant, analgesic, and anti-inflammatory. The toxicological evaluation in preclinical studies reported safety of the plant for human consumption, but comprehensive evaluation in clinical studies is required. However, further investigation is necessary for transformation of experience based treatment of plant into evidence based information. Evaluation of pharmacological activity with indicative biomarkers will help to reveal the mechanism of action of chemical constituents of plant extract. The data from preclinical studies recommends clinical evaluation of safety and efficacy of the plant. The current paper summarizes up-to-date information about a review of the traditional uses, phytochemistry, pharmacological activities, and toxicology to highlight the future prospects of the plant.

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“…No autonomic or behavioral changes were detected during first 24 h. At the end of study no mortality was reported in animals even after 14 days of observation (Pimple et al, 2012). …”

Section: Toxicity Studiesmentioning

confidence: 90%

Section: Toxicity Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Shendge

Belemkar

2018

Front. Pharmacol.

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“…Furthermore, edible natural ingredients also prevent the development of gastric ulcer in rats with diabetes, which is a risk factor for gastric ulcer (Masuda et al, 1976;Duggan et al, 1992). Pimple et al showed that co-administrations of methanolic extract of Luffa acutangula fruits and aspirin could significantly lowered ulcer index in diabetes rats in comparison with aspirin alone (Pimple et al, 2012). Not all edible, natural ingredients display the preventive efficacy in a dose-dependent manner.…”

Section: Efficacymentioning

confidence: 99%

Anti-Ulcerogenic Efficacy and Mechanisms of Edible and Natural Ingredients in Nsaid-Induced Animal Models

Man

2017

Afr J Tradit Complement Altern Med

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models. Methods: A systematic literature search was conducted on PubMed, using the terms "herbal medicines" and "gastric ulcer", "herbal medicines" and "peptic ulcer", "food" and "peptic ulcer", "food" and "gastric ulcer", "natural ingredient" and "peptic ulcer", "natural ingredient" and "gastric ulcer", "alternative medicine" and "peptic ulcer", "alternative medicine" and "gastric ulcer", "complementary medicine" and "peptic ulcer", "complementary medicine" and "gastric ulcer" in papers published in English between January 1, 1960 and January 31, 2016, resulting in a total of 6146 articles containing these terms. After exclusion of studies not related prevention, not in NSAID model or using non-edible natural ingredients, 54 articles were included in this review.Results: Numerous studies have demonstrated that edible natural ingredients exhibit antiulcerogenic benefit in NSAIDinduced animal models. The mechanisms by which edible, ingredient-induced anti-ulcerogenic effects include stimulation of mucous cell proliferation, antioxidation, inhibition of gastric acid secretion, as well as inhibition of H(+), K(+)-ATPase activities. Utilization of edible, natural ingredients could be a safe, valuable alternative to prevent the development of NSAID-induced gastric ulcer, particularly for the subjects who are long-term users of NSAIDs.

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“…Dietary nutritional components have capacity to modulate mucosal immunity, neuroendocrine functions, serotonergic metabolism, hypothalamic-pituitary-adrenal-axis and inflammatory cytokines [7]. Anti-inflammatory flavonoids and other polyphenols have been reported to be greatly beneficial in improving enteric and systemic milieu [8,9]. Pharmacological effects of triterpenoids have also been reported in several studies which modulate immune system.…”

Section: Introductionmentioning

confidence: 99%

Nutraceuticals as Chemopreventive and Therapeutic agents in Gut Associated Pathogenesis

Ahmad¹,

Nasiruddin²,

Khan³

et al. 2016

Biochem Anal Biochem

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Nutraceuticals have gained great insights in recent years due to their therapeutic implications. Secondary metabolites like glutamate, flavonoids, polyphenols and terpenoids are widespread in nature and are part of human diet. Polysaccharides of prebiotic nature are used both as therapeutic and prophylactic agents. These nutraceuticals in recent times have been reported to posses great potential to reduce antigenic and oxidative pressure in the human gut. Antioxidant rich diet is a potential therapeutic agent against reactive oxygen species induced pathogenesis. Epegenetic compounds present in antioxidant and prebiotics rich nutraceuticals mitigate and remove the causative factors associated with pathogenesis. Flavonoids and polyphenols exhibit antioxidant properties and have been recognized as potential gastroprotective agents and epigenetic modulators as well. Triterpenoids such as cucurbitacin is reported to posses anticancer activities. Glutamate is an enteric neurotransmitter that is used in improving neonatal gut function. This review comprehensively summarizes the current knowledge of gut modulating nutraceuticals which ultimately can play its role from prophylaxis of gut to its therapeutics by employing various macro and micro molecular pathways.

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Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins and antioxidants

Abstract: Thus, LAM is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.

Cited by 21 publications

References 17 publications

Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Anti-Ulcerogenic Efficacy and Mechanisms of Edible and Natural Ingredients in Nsaid-Induced Animal Models

Nutraceuticals as Chemopreventive and Therapeutic agents in Gut Associated Pathogenesis

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