Abstract:The extract of periplaneta americana had protective effect on intestinal mucosal barrier and could improve the condition and prognosis in patients with sepsis.
“…Extracts of the American cockroach have been shown to protect against intestinal mucosal barrier dysfunction . Such extracts have been shown to not only inhibit the release of inflammatory mediators, as confirmed herein, but also to suppress immune responses .…”
Section: Resultssupporting
confidence: 61%
“…Extracts of the American cockroach have been shown to protect against intestinal mucosal barrier dysfunction [15,16]. Such extracts have been shown to not only inhibit the release of inflammatory mediators, as confirmed herein, but also to suppress immune responses [16]. We thus speculate that, in addition to its ability to protect against the epithelial cell damages caused by toxin A, Peri-4 may also inhibit the mucosal immune cells responsible for the gut inflammation caused by this toxin A.…”
Section: Peri-4 Reduces Toxin A-induced Mucosal Damage and Inflammatisupporting
“…Extracts of the American cockroach have been shown to protect against intestinal mucosal barrier dysfunction . Such extracts have been shown to not only inhibit the release of inflammatory mediators, as confirmed herein, but also to suppress immune responses .…”
Section: Resultssupporting
confidence: 61%
“…Extracts of the American cockroach have been shown to protect against intestinal mucosal barrier dysfunction [15,16]. Such extracts have been shown to not only inhibit the release of inflammatory mediators, as confirmed herein, but also to suppress immune responses [16]. We thus speculate that, in addition to its ability to protect against the epithelial cell damages caused by toxin A, Peri-4 may also inhibit the mucosal immune cells responsible for the gut inflammation caused by this toxin A.…”
Section: Peri-4 Reduces Toxin A-induced Mucosal Damage and Inflammatisupporting
“…[14] The protective effect of Periplaneta americana extract on the function of the gastrointestinal mucosal barrier could be induced through the above-mentioned mechanism. A recent study [4] found that Periplaneta americana extract could reduce the level of endotoxin, thus protecting the function of the gastrointestinal mucosal barrier.…”
Section: Discussionmentioning
confidence: 99%
“…Effective medicine is expected to protect gastrointestinal mucosal barrier and reduce gastrointestinal complications. Studies [4,5] have shown that periplaneta americana extract has a positive effect on the gastrointestinal mucosa. Since periplaneta americana extract has been used in early enteral nutrition patients with SIRS in our hospitals, the present study was to determine whether it is effective in improving immune function, nutrition status and gastrointestinal complications.…”
BACKGROUND: Periplaneta americana extract is recognized to have a positive effect on gastrointestinal mucosa. This study aimed to investigate the effects of periplaneta americana extract on immune function, nutrition status and gastrointestinal complications of early enteral nutrition patients with systemic infl ammatory response syndrome (SIRS).
METHODS:Patients with SIRS were randomly divided into two groups: treatment and control groups. All patients in the two groups received conventional therapy including enteral nutrition, but periplaneta americana extract, an additional Chinese medicine, was given to the patients in the treatment group. At the beginning of treatment (0 day) and 1, 3, and 7 days after treatment, the levels of immunoglobulin (IgA), total lymphocyte count (TLC), total protein (TP) and prealbumin (PA) were respectively tested in patients' venous blood. The incidences of bloating, diarrhea, aspiration pneumonia and high blood sugar at 7 days after treatment were recorded. The mortality of the patients in 28 days was recorded.
RESULTS:At 3 and 7 days after treatment, the levels of IgA and TLC in the treatment group were higher than those in the control group (P<0.05). At 7 days after treatment, the levels of TP and PA in the treatment group were higher than those in the control group (P<0.05). The incidences of bloating and diarrhea in the treatment group were lower than those in the control group, the differences were signifi cant (P<0.05). The mortality of treatment group was lower than that of the control group (P>0.05).CONCLUSION: Periplaneta americana extract could reduce gastrointestinal complications and improve immune function and nutritional status in patients with systemic infl ammatory response syndrome.
“…The compounds were tested against various cancer cell lines and compounds 72 -- 74 showed significant cytotoxic activities against human liver (HepG2) and breast cancer (MCF-7) cells. In a small scale clinical study, sixty septic patients were treated with P. americana extract which successfully improved the condition and prognosis in patients with sepsis 129 .Figure 12Structures of isocoumarins periplatins isolated from Periplaneta americana .…”
Section: Blattodea (Cockroaches and Termites)mentioning
Nature has been the source of life-changing and -saving medications for centuries. Aspirin, penicillin and morphine are prime examples of Nature׳s gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs, moths and more. Biological activities of these natural products from insects include antimicrobial, antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects.
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