Protective Effect of Salvianolic Acid B in Acetic Acid-Induced Experimental Colitis in a Mouse Model

Abstract

In its prominent experimental studies salvianolic acid B (Sal B) is novel because of its well-defined, common physiological effects, which include anti-inflammatory, anti-depressant, cardioprotective, DNA protective, neuroprotective and hepatoprotective activity in experimental animals. Initially, Sal B was studied for its anti-inflammatory properties, used as a remedy for a wide range of disease conditions, but its specific efficacy on inflammatory bowel disease is still unclear. The aim of this current study was to understand the therapeutic potential of Sal B in an acetic acid (AA)—triggered experimental mouse colitis model. Colitis was triggered by intrarectal injection of 5% AA, and then laboratory animals were given Sal B (10, 20 and 40 μg/kg) for seven days. The ulcerated colonic mucosa was assessed by clinical experiment, macroscopical, biological and histopathological analysis. The results showed depleted SOD, CAT, GSH levels and consequential elevated MPO and MDA levels and aberrant crypt foci and mast cells were seen in the AA-induced colonic mucosa of experimental animals. The data obtained from this study demonstrate that a dose of 40 µg/kg showed an efficacious anti-ulcer effect against AA-induced experimental colitis. Based on its antioxidant efficacy, Sal B may therefore be useful as a therapeutic approach for ulcerative colitis.

Salvianolic Acid B Reduces Oxidative Stress to Promote Hair-Growth in Mice, Human Hair Follicles and Dermal Papilla Cells

“…This observation is in line with findings from Govindarasu et al, where reduced SOD activity was noted in SABtreated colon tissues. 21 Consequently, SAB-induced down-regulation of SOD may spare β-catenin levels, thereby preserving hair growth. However, further research is required to elucidate SAB's direct impact on β-catenin expression.…”

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

“…Additionally, high doses of salvianolic acid A (17) increased colon length and improved colonic tissue structure and colonic tight junction injury [ 130 ]. In addition, salvianolic acid B ( 19 ) could increase the levels of SOD, catalase (CAT), and glutathione (GSH) in the colonic mucosa and decrease the levels of peroxidase myeloperoxidase (MPO) and MDA, which can improve free radical scavenging and antioxidant capacity, decrease lipid peroxidation, and attenuate colonic ulceration, thus improving UC [ 131 ]. Moreover, another study showed that rosmarinic acid ( 13 ) significantly ameliorated DSS-induced colonic inflammation in mice by inhibiting the expression of pro-inflammatory cytokines and inflammatory mediators through the dual inhibition of NF-κB and STAT3 activation [ 132 ].…”

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

“…Despite the anti-ulcer efficacy of this chemically synthetic drug (omeprazole), it has some downsides, with risk factors for asymptomatic hypomagnesemia, hypocalcemia, and hypernatremia [16]. Therefore, researchers are racing against the time to find a natural compound or medicinal herb to be a substitute for those chemically synthetic PPIs [17][18][19].…”