Protective effect of Schisandra chinensis bee pollen extract on liver and kidney injury induced by cisplatin in rats

Huang, Haibo; Shen, Zhenjiang; Geng, Qian; Wu, Zujian; Shi, Peiying; Miao, Xiaoqing

doi:10.1016/j.biopha.2017.09.083

Cited by 50 publications

(47 citation statements)

References 60 publications

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“…Malondialdehyde is a product of lipid peroxidation, and it is widely used as an indicator of lipid peroxidation. 3 As Table 3 shows, the GSH content in the UTRP, BTRP, and STRP groups showed a significant increase of approximately 214.87%, 215.05% and 219.89% respectively compared to those in the model group but there were no significant differences in the GSH content in the UTRP, BTRP, and STRP groups. Furthermore, the model group had significantly higher values of MDA than the UTRP and control groups.…”

Section: Effect On Glutathione (Gsh) and Malondialdehyde (Mda) In Agimentioning

confidence: 88%

“…This was in agreement with previous studies on bee pollen. 3 The ultrasonic treatment and the ball-milling treatment also improved GSH content and prevented the generation of MDA.…”

Section: Effect On Glutathione (Gsh) and Malondialdehyde (Mda) In Agimentioning

confidence: 95%

“…Water dispersant and shading rates from 5% to 10% were used. The mean particle size was characterized by the surface area weighted mean diameters of equivalent sphere, D [3,2].…”

Section: Ultrasonic Treatmentmentioning

confidence: 99%

“…Hence, the liver and kidney can reflect antioxidant activity of bee pollen. 3 The thymus and spleen are the main immune organs, which can reflect oxidative damage level related to the aging process. 28 Thus, the organ indexes were measured to evaluate the effects of rose bee pollen under different wall-breaking treatments on the aging mice.…”

Section: Effect Of Ultrasonic and Ball-milling Treatment On Antioxidamentioning

confidence: 99%

“…Thus it has various therapeutic properties including anti-cancer, antioxidant, and antibacterial activity, and organ protection. 3,4 The compounds and biological effects vary depending on the origins of the pollen. 5 Bee pollen has therefore been used widely as a traditional medicine and for human nutrition.…”

Section: Introductionmentioning

confidence: 99%

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Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components

et al. 2019

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BACKGROUND: Bee pollen has been regarded as a complete nutritional human dietary supplement but its nutrient absorption and biological effects may be restricted by the complex pollen wall. The aim of this study was to explore the effects of ultrasonic and ball-milling treatment on the release of nutritional components and on in vitro and in vivo antioxidant effects of rose (Rosa rugosa) bee pollen. RESULTS: Bee pollen walls were broken to varying degrees, nutrients were released, and in vitro and in vivo antioxidant effects of bee pollen were improved. The scavenging effects of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2 ′ -azinobis(3-ethylbenzothiazolone-6-sulfonic acid) (ABTS) radicals, and oxygen radical absorbance capacity (ORAC) were improved. In aging mice, wall-breaking treatment led to better organ recovery, enhanced superoxide dismutase (SOD) and catalase (CAT) effects, and malondialdehyde (MDA) reduction. Eight compounds of rose bee pollen ethanol extract, including isorhamnetin 3-O-diglucoside and N ′ , N ′′ , N ′′′ -dicaffeoyl p-coumaroyl spermidine were identified by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-QTOF-MS/MS) assay.CONCLUSION: This study showed that ultrasonic treatment had greater wall-disruption effects of bee pollen on nutrient release and antioxidant effect promotion. In conclusion, rose bee pollen, with wall-breaking treatments, may have potential value as an ingredient in functional food processing.

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Section: Effect On Glutathione (Gsh) and Malondialdehyde (Mda) In Agimentioning

confidence: 88%

“…This was in agreement with previous studies on bee pollen. 3 The ultrasonic treatment and the ball-milling treatment also improved GSH content and prevented the generation of MDA.…”

Section: Effect On Glutathione (Gsh) and Malondialdehyde (Mda) In Agimentioning

confidence: 95%

“…Water dispersant and shading rates from 5% to 10% were used. The mean particle size was characterized by the surface area weighted mean diameters of equivalent sphere, D [3,2].…”

Section: Ultrasonic Treatmentmentioning

confidence: 99%

Section: Effect Of Ultrasonic and Ball-milling Treatment On Antioxidamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components

et al. 2019

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Anti‐apoptotic effect of vinpocetine on cisplatin‐induced hepatotoxicity in mice: The role of Annexin‐V, Caspase‐3, and Bax

Habib

Abdelrahman

Rahim

et al. 2020

J Biochem & Molecular Tox

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Hepatic damage is one of the most common complications related to cisplatin (Cis) use. Recently, liver protection lines are being discovered to avoid hepatic cell death as a result of oxidative, inflammatory, and apoptotic disturbance. Limited data reported the hepatoprotective effect of vinpocetine (Vin) in acute liver injury models. This study was designed to determine the potential protective effect of Vin (10-30 mg/kg, orally) against Cis-induced liver injury (10 mg/kg, IP) in mice. Vin administration for 1 week before Cis injection until the end of the experiment. On the 6th day after Cis injection, mice were anesthetized, blood and tissue samples were collected. Hepatic function, histological changes, oxidative stress, inflammation, and apoptotic markers were investigated. Vin administration ameliorated liver injury as indicated by decreased liver injury parameters; serum aminotransferases, ALK-P, GGT, and bilirubin, restored the anti-oxidant status by decrease MDA and NO x , and increased GSH and SOD, inhibited inflammation (IL-6, TNF-α, NFκB-p65, and iNOS) and apoptosis (Annexin-V, Bax, and Caspase-3) parameters. Vin confers dose-dependent protection against Cis-induced liver injury. The hepatoprotective effect of Vin involved anti-oxidative, anti-inflammatory, and anti-apoptotic activities.

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Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin‐induced nephrotoxicity in Spraque–Dawley rats

Kumaş

Gepdíremen

Karataş

et al. 2023

J Biochem & Molecular Tox

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Cis‐diamminedichloroplatinum (II) (cisplatin, Cis) is widely employed to treat several types of cancer. It has many important toxic side effects; one of the most important of which is nephrotoxicity. Clemizole hydrochloride (Clem) as the most potent inhibitor of TRPC5 channels was tested in an animal model of Cis‐induced nephrotoxicity. Rats were divided into the following groups: control; Cis (8 mg/kg); Cis + 1 mg/kg Clem; Cis + 5 mg/kg Clem; Cis + 10 mg/kg Clem. Kidney injury was detected by histopathological and biochemical analysis. Urine urea nitrogen (UUN), creatinine, urine neutrophil gelatinase‐associated lipocalin (NGAL), serum catalase (CAT), and malondialdehyde (MDA) levels were determined by enzyme‐linked immunosorbent assay. Total antioxidant status (TAS) and total oxidant status (TOS) were studied using a colorimetric assay. Nephrin, synaptopodin, and Rac family small GTPase 1 (RAC1) expressions were detected by Western blot analysis. Cis was found to induce histopathological alterations, including tubular degeneration, congestion, hemorrhage, hyaline casts, glomerular collapse, and apoptotic cell death. Clem at a dose of 1 and 5 mg/kg attenuated histopathological alterations. UUN, creatinine, and NGAL levels increased in the Cis‐administered group, while all doses of Clem decreased in those. CAT and TAS levels decreased, while TOS and oxidative stress index levels increased in the Cis‐treated group. A dose of 1 and 5 mg Clem showed antioxidant effects against oxidative stress. Cis induced lipid peroxidation by increasing MDA levels. All doses of Clem reduced MDA levels. Nephrin and synaptopodin expressions were decreased by Cis, and all doses of Clem increased that. All doses of Clem successfully depressed RAC1 expression. Clem showed a highly ameliorating effect on toxicity caused by Cis by blocking TRPC5 calcium channels.

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Protective effect of Schisandra chinensis bee pollen extract on liver and kidney injury induced by cisplatin in rats

Cited by 50 publications

References 60 publications

Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components

Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components

Anti‐apoptotic effect of vinpocetine on cisplatin‐induced hepatotoxicity in mice: The role of Annexin‐V, Caspase‐3, and Bax

Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin‐induced nephrotoxicity in Spraque–Dawley rats

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