Protective effect of sulfated polysaccharides from a Celluclast-assisted extract of Hizikia fusiforme against ultraviolet B-induced photoaging in vitro in human keratinocytes and in vivo in zebrafish

Wang, Lei; Oh, Jae Young; Yang, Hye-Won; Kim, Hyun Soo; Jeon, You‐Jin

doi:10.1007/s42995-019-00006-1

Cited by 21 publications

(18 citation statements)

References 20 publications

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“…UVB, a subtype of UV, is thought to cause more stress to the skin than other subtypes of UV. Previous reports suggested that UVB causes both epidermic and dermic damage by stimulating intracellular ROS generation [15,28]. The above data indicated that EMC possesses potent ROS scavenging effect and suggests the photoprotective potential of EMC.…”

Section: Protective Effect Of Emc Against Uvb-induced Photodamagesupporting

confidence: 53%

“…The zebrafish were maintained following the conditions described previously [14,15]. The experiment was approved by the Animal Care and Use Committee of the Jeju National University (Approval No.…”

Section: Maintenance Of Cell Lines and Zebrafishmentioning

confidence: 99%

“…EMC-treated HaCaT cells were irradiated with UVB (30 mJ/cm 2 ) in PBS solution (1×). The intracellular ROS level and the viability of UVB-irradiated HaCaT cells were investigated with the DCF-DA and the MTT assay, respectively [15,34]. In addition, the apoptosis body formation in UVB-irradiated HaCaT cells was detected with the Hoechst staining assay according to the protocol described by Wang et al [15].…”

Section: Determination Of the Effect Of Emc On α-Msh-stimulated Melanmentioning

confidence: 99%

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The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

et al. 2020

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Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from Ecklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries.

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Section: Protective Effect Of Emc Against Uvb-induced Photodamagesupporting

confidence: 53%

Section: Maintenance Of Cell Lines and Zebrafishmentioning

confidence: 99%

Section: Determination Of the Effect Of Emc On α-Msh-stimulated Melanmentioning

confidence: 99%

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The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

et al. 2020

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“…and found the carrageenan effectively reduced the intracellular ROS level in UVB-irradiated HaCaT cells and increased the viability of the cells [ 36 ]. In our previous study, we investigated the UVB protective effect of the crude sulfated polysaccharides isolated from H. fusiforme (HFPS) and found that HFPS effectively protected HaCaT cells against UVB-induced photoaging [ 39 ]. However, the photoprotective effect of the purified fucoidan and its potential mechanism of action have not been investigated so far.…”

Section: Resultsmentioning

confidence: 99%

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Wang

Kim

et al. 2020

Marine Drugs

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Previous studies suggested that fucoidan with a molecular weight of 102.67 kDa, isolated from Hizikia fusiforme, possesses strong antioxidant activity. To explore the cosmeceutical potential of fucoidan, its anti-photoaging and anti-melanogenesis effects were evaluated in the present study. The anti-photoaging effect was investigated in ultraviolet (UV) B-irradiated human keratinocytes (HaCaT cells), where fucoidan effectively reduced the intracellular reactive oxygen species level and improved the viability of the UVB-irradiated cells without any cytotoxic effects. Moreover, fucoidan significantly decreased UVB-induced apoptosis in HaCaT cells by regulating the protein expression of Bax, Bcl-xL, PARP, and Caspase-3 in HaCaT cells in a concentration-dependent manner. The anti-melanogenesis effect of fucoidan was evaluated in B16F10 melanoma cells that had been stimulated with alpha-melanocyte-stimulating hormone (α-MSH), and fucoidan treatment remarkably inhibited melanin synthesis in α-MSH-stimulated B16F10 cells. Further studies indicated that fucoidan significantly suppressed the expression of tyrosinase and tyrosinase-related protein-1 and -2 (TRP-1 and-2) in B16F10 cells by down-regulating microphthalmia-associated transcription factor (MITF) through regulation of the ERK–MAPK (extracellular signal regulated kinase-mitogen activated protein kinase) pathway. Taken together, these results suggest that fucoidan isolated from H. fusiforme possesses strong anti-photoaging and anti-melanogenesis activities and can be used as an ingredient in the pharmaceutical and cosmeceutical industries.

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“…Marine algae are rich in compounds that possess various bioactivities including UV protection. In our ninth paper, Wang et al (2019) evaluate the antioxidant activities and UV-protective effect of sulfated polysaccharides, derived from the celluclast-assisted extract of a brown alga Hizikia fusiforme. They indicate that these polysaccharides significantly reduce UVB-induced photo-damage in in vitro and in vivo models and can be used as a potential natural cosmeceutical ingredient.…”

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confidence: 99%

Marine life science and technology (MLST): a new journal highlighting all aspects of marine biology and biotechnology research

Zhang

2019

Mar Life Sci Technol

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The majestic nature of the oceans and their charismatic flora and fauna clearly justify the study of marine life, especially to the general public. Consequently, the exploration of marine biota has provided both insights and highlighted challenges, leading to the appreciation that marine biology and its supporting technology must be at the forefront of 21st century science. Still, this field is not progressing as fast or in as much detail as might be expected, or needed. Possibly the most notable gap is the lack of academic journals that cover cross-disciplinary topics.Marine sciences are facing a growing number of complex challenges that researchers are currently unable to solve through studies in any single discipline. We suggest that the solution is to foster synergies arising from crossdisciplinary studies. For example, many marine drugs and lead compounds have been discovered, directly or indirectly, through studies on the exploitation of marine bioresources that employ genetic techniques and evaluate chemical ecology. Likewise, studies on the community structure of marine plankton and their ecological functions have facilitated our understanding of marine environmental sciences. Our new journal provides a venue for such high-impact, cross-disciplinary studies.Specifically, Marine Science and Technology (MLST) now offers a platform that introduces discoveries and theories associated with marine organisms, fisheries science, marine drugs, bioproducts, and bioresources, with an emphasis, but not exclusively, on biological technology and biological oceanography. It is co-sponsored by two leading institutions in marine science studies-the Ocean University of China and the Pilot National Laboratory for Marine Science and Technology, China-and is published by Springer-Nature Press. The sponsors will cover all fees including those supporting Open-Access for articles published before 2022. To ensure the success of this comprehensive journal we have involved more than 80 editors, all of whom are active researchers (nearly two-thirds are from outside of mainland China) and three full-time professional editors.To illustrate our scope, the first issue features eight review articles and two research articles that have been contributed by our editors; below, we introduce these.Epigenetic research focuses on heritable changes beyond DNA, a phenomenon that will influence all marine life. The model microbial eukaryote Tetrahymena has facilitated numerous studies and benefited many fields. In our first paper, Cheng et al. (2019) summarize their progress in understanding epigenetic mechanisms using Tetrahymena. This review reports their efforts to generate a high-resolution DNA N 6 -methyladenine (6 mA) map, evaluate the determinants for nucleosome distribution, demonstrate the roles of RNAi-dependent Polycomb repression pathways on transposable elements, and discover the functions of histone methylation in replication elongation. Admittedly, Tetrahymena is a freshwater species, but we recognize that epigenetics studies in non...

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Protective effect of sulfated polysaccharides from a Celluclast-assisted extract of Hizikia fusiforme against ultraviolet B-induced photoaging in vitro in human keratinocytes and in vivo in zebrafish

Cited by 21 publications

References 20 publications

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Marine life science and technology (MLST): a new journal highlighting all aspects of marine biology and biotechnology research

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