Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes

John, Susan; Kale, Manisha; Rathore, Nisha; Bhatnagar, Deepak

doi:10.1016/s0955-2863(01)00160-7

Cited by 273 publications

(158 citation statements)

References 16 publications

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“…It was shown that vitamin E may protect cells and tissues from oxidative damage and prevent the formation of toxic oxidation products such as those formed from unsaturated fatty acids [4,37]. Vitamin E was effective in scavenging lipid radicals with the particular function of preventing lipid peroxidation in membranes and lipoproteins [38][39][40].…”

Section: Groupsmentioning

confidence: 99%

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

Abdel-Hamid

2014

Folia Histochem Cytobiol.

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Kidney is one of the most affected organs by aluminium toxicity. This study aimed to investigate the effect of aluminium chloride on the kidney of pregnant rats and to assess the efficiency of vitamin E and selenium in ameliorating this effect. Forty virgin albino rats were randomly divided into two main groups. Control rats were further divided into negative control group (C1, n = 10) which received distilled water and positive control group (C2, n = 10) that received vitamin E (VE, 150 mg/kg/day) and selenium (NaSe 150 µg/kg/day) for 3 months through intra-gastric tube. The experimental group was divided into an E1 subgroup in which rats received aluminium chloride (AlCl 3 , 150 mg/kg/day, n = 10) and E2 subgroup (n = 10) in which animals received the same dose of AlCl 3 plus VE and selenium at the same doses as C2 group for 3 months through intra-gastric tube. Conception of rats was allowed. AlCl 3 , VE and NaSe were given through intragastric tube during the whole length of the pregnancy, at the same doses as before pregnancy. At the 20th day of gestation dams were sacrificed, kidneys were dissected and processed for routine histological and immunohistochemical staining for identification of T-lymphocytes and macrophages. Integrated optical density of both cell types was assessed. AlCl3 administration induced histopathological changes in the kidney of pregnant rats and increased the density of CD3 and CD68 immunoreactive cells, suggestive of the associated aluminium-induced inflammatory process. Vitamin E and selenium minimized these harmful effects. The results suggest that diets rich in vitamin E and selenium and their supplements are advised particularly during pregnancy to alleviate the effects of possible excessive aluminium exposure.

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Section: Groupsmentioning

confidence: 99%

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

Abdel-Hamid

2014

Folia Histochem Cytobiol.

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“…Residual amount of Organophosphate pesticides (OPS) have been detected in the soil, water bodies, vegetables, grains and other food production (John et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

The impact of the organophosphate insecticide "Malathion" on rat and the possible ameliorating role of "Thymoquinone"

Hafez¹,

El-Atrash²,

Massoud³

et al. 2017

Egypt. J. Exp. Biol. (Zoo.)

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E za r Ha z a a H a m e d H a f e z A f a f Mo k h t a r E l -A t ra s h A h me d A b d e l -N a i m M a s s o u d M o h a m m e d Fa ra g A b d u l -A zi z A h m e d A t t i aThe impact of the organophosphate insecticide "Malathion" on rat and the possible ameliorating role of "Thymoquinone" ABSTRACT:Hepatotoxicity and nephrotoxicity are two of the most common healthy problems in the world. Extensive research was carried out to document the powerful properties of Nigella sativa (N. sativa) as an anti-tumour, bactericide, anti-cestode, antinematode, antiinflammatory, analgesic, anti -diabetic and diuretic with many other uses. Little is known about the Nigella sativa anti-toxic property in liver and kidney, thus our current study was designed to investigate the protective effects of Thymoquinone (TQ) "the main bioactive constituent of the volatile oil of Nigella sativa seeds" on the toxicity that induced by Malathion after short term (3 week) in male albino rats. Forty male adult albino rats were randomly divided into four groups (10 rats each group): 1 st group served as the control group received olive oil daily by oral stomach tube, 2 nd one is the treated group, received Malathion as a spray (570 mg/kg) in closed place for 1 hr. every day for a period of 3 weeks. 3 rd group received Malathion (with the same technique) after treated with Thymoquinone in a dose of 20 mg/kg/day orally, while the 4 t h one received Malathion (with the same technique) after treated with Thymoquinone in a dose of 40 mg/kg/day orally.Administration of Malathion significantly inc reased the concentration of liver function tests: "ALT, AST, and ALP", and Kidney function tests: "urea and creatinine". Also, it causes various histopathological changes in liver and kidney tissues. But in the groups, that treated with Thymoquinone plus Malathion: the liver function and kidney function parameters improved as a result of tissues improvement. Overall, the results of present study supported the traditional use of N. sativa and its derived products as a therapeutic agent for many diseases.

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“…Lipid peroxidation continues up to the formation of MDA which can modify the proteins and together with membrane lipids, cause membrane damage. Protecting activity of antioxidant defense system may preserve MDA at low level (20)(21)(22). Studies in stored whole blood components play an important role to understand the alteration of oxidative stress during storage (23).…”

Section: Discussionmentioning

confidence: 99%

In Stored Human Blood, The Inhibitor Effect of Tannic Acid and Caffeic Acid on Lipid Peroxidation and Oxidative DNA Damage

Huyut¹,

Şekeroğlu²,

Balahoroğlu³

et al. 2016

Eastern J Med

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Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes

Cited by 273 publications

References 16 publications

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

The impact of the organophosphate insecticide "Malathion" on rat and the possible ameliorating role of "Thymoquinone"

In Stored Human Blood, The Inhibitor Effect of Tannic Acid and Caffeic Acid on Lipid Peroxidation and Oxidative DNA Damage

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