Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats

Abstract

ObjectiveThis study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms.MethodsFifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected, and the myocardial B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X (Bax) protein expressions were determined.ResultsCompared with the model group, in the high-dose baicalin group the ST segment height and LVEDP were significantly decreased (P<0.05), the LVSP was significantly increased (P<0.05), the serum LDH, CK-MB and TXA2 levels were significantly decreased (P<0.05), the PGI2 level was significantly increased (P<0.05), the myocardial SOD level was significantly increased (P<0.05), and the myocardial MDA level was significantly decreased (P<0.05); the myocardial Bcl-2 protein level was significantly increased, and the Bax protein level was significantly decreased (P<0.05).ConclusionBaicalin has protective effects on myocardial infarction in rats. The possible mechanisms may be related to its resistance to oxidative stress, and up-regulation of Bcl-2 protein expression and down-regulation of Bax protein expression in myocardial tissue.

Chemoprotective effect of baicalin against cyclophosphamide induced ovarian toxicity in mice via inhibition of TGF-β

“…Subcutaneous administration of CP (200 mg/kg) was used for the induction of ovary toxicity [ 24 ]. The tested drug given to the mice orally in the form of suspension [ 25 ]. Oral suspension was prepared using the 1 % CMC suspension.…”

“…The mice were divided into different groups as follow and each group contains the 12 mice in each groups. Group I: normal control; Group II: cyclophosphamide (CP) control; Group III-IV: CP control treated with baicalin (1.25, 5 and 10 mg/kg) [ 25 ], respectively. The body weight and tumor volume of the experimental rodents were estimated at regular time intervals.…”