Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney

Hermenean, Anca; Ardelean, Aurel; Stan, Miruna Silvia; Herman, Hildegard; Mihali, Ciprian-Valentin; Costache, Marieta; Dinischiotu, Anca

doi:10.1016/j.cbi.2013.06.016

Cited by 84 publications

(61 citation statements)

References 61 publications

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“…CCl4 intoxicated group also showed significantly increased serum urea and creatinine level with severe necrotic degeneration of both glomeruli and tubules ( Figure 2 to Figure 6). The results of CCl4 were similar to Sakrand and Lamfon 23 , Andriţoiu et al, 24 , Mohamed et al, 25 and Hermenean et al, 26 .…”

Section: Discussionsupporting

confidence: 77%

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Saxena¹,

Shahani²

2017

Int. Res. J. Pharm.

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Antidepressants induced metabolic syndrome is a major public health problem in the treatment of psychiatric disorders which leads to an increased risk of cardiovascular disease, non-alcoholic hepatic steatosis and renal dysfunction. Psychiatric disorder is a mental illness that includes depression, schizophrenia, and anxiety disorder that affect millions of people around the world. The purpose of present study was to investigate the protective role of broccoli powder against continuous ingestion of antidepressant drug induced nephrotoxicity in Swiss albino mice. In present study mice were continuously treated with escitalopram antidepressant drug (20 mg/kg/b.w. orally) for 4, 8 and 12 weeks. The escitalopram drug intoxicated group showed elevation in serum urea and creatinine level. Escitalopram drug intoxicated group also showed degeneration of glomerulus and renal tubule that are comparable with carbon tetrachloride (33 mg/kg) group considered as positive control. Group that received both broccoli powder and escitalopram drug (200 mg/kg + 20 mg/kg) significantly reduced elevated level of serum urea and creatinine with mild degeneration of glomerulus and renal tubule as compared to antidepressant drug intoxicated group.

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Section: Discussionsupporting

confidence: 77%

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Saxena¹,

Shahani²

2017

Int. Res. J. Pharm.

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“…26 The release of these cytokines plays a central role in the recruitment and activation of inflammatory cells, leading to skin damage after UVB exposure. 6,13,15,42,43 Moreover, the inhibition of these cytokines is considered a therapeutic approach to control skin cancer progression and metastasis, psoriasis, contact dermatitis, and other diseases.…”

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confidence: 99%

Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice

et al. 2015

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Ultraviolet B (UVB) irradiation may cause inflammation- and oxidative-stress-dependent skin cancer and premature aging. Naringenin (1) has been reported to have anti-inflammatory and antioxidant properties, but its effects and mechanisms on UVB irradiation-induced inflammation and oxidative stress are still not known. Thus, the present study aimed to investigate the potential of naringenin to mitigate UVB irradiation-induced inflammation and oxidative damage in the skin of hairless mice. Skin edema, myeloperoxidase (neutrophil marker) and matrix metalloproteinase-9 (MMP-9) activity, and cytokine production were measured after UVB irradiation. Oxidative stress was evaluated by 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS) scavenging ability, ferric reducing antioxidant power (FRAP), reduced glutathione levels, catalase activity, lipid peroxidation products, superoxide anion production, and gp91phox (NADPH oxidase subunit) mRNA expression by quantitative PCR. The intraperitoneal treatment with naringenin reduced skin inflammation by inhibiting skin edema, neutrophil recruitment, MMP-9 activity, and pro-inflammatory (TNF-α, IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-12, IL-13, IL-17, IL-22, and IL-23) and anti-inflammatory (TGF-β and IL-10) cytokines. Naringenin also inhibited oxidative stress by reducing superoxide anion production and the mRNA expression of gp91phox. Therefore, naringenin inhibits UVB irradiation-induced skin damage and may be a promising therapeutic approach to control skin disease.

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“…Similarly, Cavia-Saiz et al (23) showed than naringenin was able to inhibit lipid peroxidation in rat liver tissue induced by potent oxidants, hydroxyl radical and peroxyl radical. In carbon tetrachloride-induced nephrotoxicity, naringenin has also shown the ability for nephroprotection, as demonstrated by several assays, including the measurement of MDA in kidney tissue (24). The antioxidant activity of flavonoids and their metabolites depends on their structural features, like the arrangement of functional hydroxyl groups, O-methylation, differences in the main nuclear structure, such as the presence or absence of an unsaturated 2-3 bond and/or a 4-carbonyl group, degree of polymerisation and other (25).…”

Section: Resultsmentioning

confidence: 99%

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

Sirovina

Oršolić

Gregorović

et al. 2016

Archives of Industrial Hygiene and Toxicology

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The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg -1 , i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg -1 per day) for seven days. Naringenin's impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected wih oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.

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Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney

Cited by 84 publications

References 61 publications

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

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