Protective Effects of Pterostilbene against Acetaminophen‐Induced Hepatotoxicity in Rats

El-Sayed, El-Sayed M.; Mansour, Ahmed M.; Nady, M.

doi:10.1002/jbt.21604

Cited by 45 publications

(34 citation statements)

References 49 publications

(51 reference statements)

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“…In addition, it shows efficacy against multiple diseases including ischemia-reperfusion damage, inflammation, and tumors. In vivo studies showed the effect of pterostilbene in reducing xanthine oxidase expression and improving ischemic injury of renal, testicular, muscular, ovarian, spinal cord, and brain tissues (Chen et al, 2015;El-Sayed et al, 2015). Hence, the results of this study were consistent with previous studies.…”

Section: Discussionsupporting

confidence: 90%

Pterostilbene as treatment for severe acute pancreatitis

et al. 2016

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ABSTRACT. Acute pancreatitis (AP) has a fast onset and progression, which lead to an unfavorable prognosis. Therefore, the development of novel drugs for its treatment is critical. As a homologous derivative of resveratrol, pterostilbene exerts a variety of effects including anti-inflammatory, antioxidant, and antitumor effects. This study investigated the potential of pterostilbene for treatment of severe AP (SAP) and related mechanisms. Effects of pterostilbene were evaluated in a Wistar rat model of AP. Serum levels of amylase (AMY), creatinine (Cr), and alanine aminotransferase (ALT) were quantified. Furthermore, serum levels of tumor necrosis factor (TNF)-a and interleukin (IL)-1b were quantified using enzyme-linked immunosorbent assay. Nuclear factor (NF)-kB expression in pancreatic tissues was quantified by realtime PCR and western blotting. The production of reactive oxygen species (ROS) was determined using a spectrometer, while superoxide dismutase (SOD) activity was assayed. In the AP rat model, the expression of inflammatory markers TNF-a and IL-1b, expression of NF-kB, and serum indices (AMY, Cr, and ALT) increased compared to the corresponding levels in the control group (P < 0.05). Pterostilbene reduced serum levels of TNF-a and IL-1b; decreased NF-kB gene expression, serum indices, and ROS generation; and increased SOD activity in a dose-dependent manner. In conclusion, pterostilbene can alleviate SAP-induced tissue damage by decreasing the inflammatory response and by promoting antioxidation leading to the protection of pancreatic tissues.

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Section: Discussionsupporting

confidence: 90%

Pterostilbene as treatment for severe acute pancreatitis

et al. 2016

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“…NO is a well-established marker of inflammation, and inhibition of its production can be a useful therapeutic strategy in inflammatory diseases [10, 34, 35]. Additionally, other inflammatory mediators, such as TNF- α , IL-1 β , and IL-6, are associated with the severity of hepatic injury [8, 36, 37].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Citral on Acetaminophen‐Induced Liver Toxicity in Mice

Uchida

Silva-Filho

Cardia

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis. The effect of citral on leukocyte migration and antioxidant activity was evaluated in vitro. Citral pretreatment decreased significantly the levels of ALT, AST, ALP, and γGT, MPO activity, and NO production. The histopathological analysis showed an improvement of hepatic lesions in mice after citral pretreatment. Citral inhibited neutrophil migration and exhibited antioxidant activity. Our results suggest that citral protects the liver against liver toxicity induced by APAP.

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“…The elevated levels of liver enzymes such as aspartate and ALT, AST, ALP, and total serum bilirubin found in CCl 4 induced liver injuries are reduced significantly by its use of silymarin both in animal and clinical studies. 24 Administration of aqueous extracts of E. alba showed significant hepatoprotective activity at 250 mg/kg and 500 mg/kg, which were comparable to the standard control silymarin at 50 mg/kg. The hepatoprotective effects were more pronounced with a higher dose of 500 mg/kg of aqueous extract of E. alba.…”

Section: Discussionmentioning

confidence: 85%