The present study was undertaken to evaluate the protective effect of pterostilbene against acetaminophen-induced hepatotoxicity. Silymarin was used as a standard hepatoprotective agent. A single dose of acetaminophen (800 mg/kg i.p.), injected to male rats, caused significant increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, total cholesterol, triglycerides, tumor necrosis factor alpha, and hepatic contents of malondialdehyde, nitric oxide, caspase-3, hydroxyproline, with significant decreases in serum HDL-cholesterol, total proteins, albumin, and hepatic activities of reduced glutathione, superoxide dismutase and catalase as compared with the control group. On the other hand, administration of each of pterostilbene (50 mg/kg, p.o.) and silymarin (100 mg/kg, p.o.) for 15 days before acetaminophen ameliorated liver function and oxidative stress parameters. Histopathological evidence confirmed the protection offered by pterostilbene from the tissue damage caused by acetaminophen. In conclusion, pterostilbene possesses multimechanistic hepatoprotective activity that can be attributed to its antioxidant, anti-inflammatory, and antiapoptotic actions.

Interferometric devices have drawn great interest in all-optical signal processing for their high-speed photonic activity. Quantum-dot semiconductor optical amplifier (QD-SOA)-based gate has added a new momentum in this field to perform all-optical logic and algebraic operations. In this paper, for the first time, a new scheme for all-optical full adder using fife QD-SOA based Mach-Zehnder interferometers is theoretically investigated and demonstrated. The proposed scheme is driven by three input data streams; two operands and a bit carried in from the next less significant stage. The proposed scheme consists of two XOR, two AND, and one OR gate. The impact of the peak data power as well as of the QD-SOAs current density, maximum modal gain, and QD-SOAs length on the ER and Q-factor of the switching outcome are explored and assessed by means of numerical simulation. The operation of the system is demonstrated with 160 Gbit/s.

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