Protective effects of silymarin and curcumin on cyclophosphamide-induced cardiotoxicity

Avcı, Hamdi; Epikmen, Erkmen Tuğrul; İpek, Emrah; Tunca, Recai; Birincioğlu, S. Serap; Akşit, Hasan; Sekkin, Selim; Akkoç, Ayşe Nur; Boyacıoğlu, Murat

doi:10.1016/j.etp.2017.02.002

Cited by 56 publications

(40 citation statements)

References 44 publications

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“…In biological tests, CP caused a significant reduction (p < 0.05) in both SOD and CAT activity of liver tissue.In addition, we observed a decrease in the GSH for all tissues, as described by [34] and [35]. This occurs because during the metabolism of CP ROS is generated that lead to the depletion of antioxidant enzymes in different tissues [36][37][38][39]. In his studies [37] found that acrolein induces [38].…”

Section: Discussionsupporting

confidence: 65%

Antioxidant potential of Carica papaya Linn (Caricaceae) leaf extract in mice with cyclophosphamide induced oxidative stress

Luiz

Cunha

Aguiar

et al. 2020

Sci Med

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AIMS: This study aimed to investigate the effects of crude extract of Carica papaya leaves on oxidative stress in mice induced by cyclophosphamide, as well as phytochemical profile characterization of this extract.METHODS: The male Swiss mice received 15 days of treatment with the extract (500 mg kg-1, via gavage) and intraperitoneal injection of cyclophosphamide (75 mg kg-1) or saline (0.9%) on the 15th day. After 24 h the last treatment, the animals were anesthetized for blood withdrawal, sacrificed and removal of the organs for analyses (liver, kidney and heart). In the biochemical tests were determined: hematological parameters in blood, aminotransferases, alkaline phosphatase, glucose and total cholesterol dosages in plasma, enzymatic and non-enzymatic antioxidants and lipid damage marker were evaluated in different tissues, besides genotoxic and histopathological analyzes.RESULTS: In the extract of Carica papaya leaves, the flavonoids quercetin-3β-D-glucoside and rutin were identified, besides present positive results for alkaloids, saponins and tannins. This extract increased the activity of glutathione-S-transferase and catalase enzymes in the liver and reduced the levels of reduced glutathione in the kidneys and hematocrit levels, red cell count, and hemoglobin. It promoted the decrease of the reactive species of thiobarbituric acid (TBARS) in the kidneys and the activity of enzyme aspartate aminotransferase in the plasma and was antimutagenic in the micronucleus test.CONCLUSIONS: The study showed that extract of Carica papaya was beneficial against oxidative events and prevented DNA damage. The extract also showed hepatotoxicity, therefore prolonged infusion of papaya leaves is not advisable.

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Section: Discussionsupporting

confidence: 65%

Antioxidant potential of Carica papaya Linn (Caricaceae) leaf extract in mice with cyclophosphamide induced oxidative stress

Luiz

Cunha

Aguiar

et al. 2020

Sci Med

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“…Avci et al [61] Female Wistar albino rats Animals were treated with 100 mg/kg/day silymarin (SLY) by oral gavage for 14 days and 30 mg/kg/day CP intraperitoneally starting from the seventh day and 100 mg/kg/day curcumin (CUR) by gavage for 14 days plus 30 mg/kg/day CP intraperitoneally starting from the seventh day.…”

Section: Future Hopes and Hurdles Associated With Cardioprotective Anmentioning

confidence: 99%

The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Ayza

Zewdie

Tesfaye

et al. 2020

Oxidative Medicine and Cellular Longevity

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The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously been shown to induce complications within the setting of bone marrow transplantation. More recently, cardiotoxicity has been shown to be a dose-limiting factor during cyclophosphamide therapy, and cardiooncology is getting wider attention. Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress. As such, this review focuses on antioxidants and their role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity. It will give special emphasis to the cardioprotective effects of natural, plant-derived antioxidants that have garnered significant interest in recent times.

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“…e pathologist (A. M. Abdel-Moneim) performing the evaluation was blinded to the treatment assignments of various study groups. e criteria of myocardial lesions included myocardial disorganization, necrotic injury, leukocyte in ltration, and nuclear pyknosis [39,40]. e severity of every pathological alteration was graded semi quantitatively as previously described [41].…”

Section: Histopathological Studiesmentioning

confidence: 99%

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Abdel‐Moneim

Alzahrani

Ali

et al. 2019

BioMed Research International

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Acrylamide (AA) is a well-known potent carcinogen and neurotoxin that has been recently linked to atherosclerotic pathogenesis. The present study is aimed at investigating the protective effect of silymarin (SIL) as an antioxidant against AA-induced hyperlipidemic cardiomyopathy in male rats. The obtained results showed that animals exposed to AA exhibited a significant increase in the levels of cardiac serum markers, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol with a significant decrease in high-density lipoprotein cholesterol. Furthermore, AA intoxication significantly increased the malondialdehyde level (a hallmark of lipid peroxidation) and reduced antioxidant enzyme activities (i.e., superoxide dismutase, catalase, and glutathione peroxidase). SIL administration significantly attenuated all these biochemical perturbations in AA-treated rats, except for the decreased high-density lipoprotein cholesterol. Our results were confirmed by histopathological assessment of the myocardium. In conclusion, this study demonstrated a beneficial effect of SIL therapy in the prevention of AA-induced cardiotoxicity by reversing the redox stress and dyslipidemia in experimental animals.

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Protective effects of silymarin and curcumin on cyclophosphamide-induced cardiotoxicity

Cited by 56 publications

References 44 publications

Antioxidant potential of Carica papaya Linn (Caricaceae) leaf extract in mice with cyclophosphamide induced oxidative stress

Antioxidant potential of Carica papaya Linn (Caricaceae) leaf extract in mice with cyclophosphamide induced oxidative stress

The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

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