Protective effects of vitamins and selenium compounds in yeast

Bronzetti, G.; Cini, M.; Andreoli, Elisabetta; Caltavuturo, Leonardo; Panunzio, Michele F.; Croce, C. Della

doi:10.1016/s1383-5718(01)00213-3

Cited by 68 publications

(41 citation statements)

References 38 publications

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“…At low concentrations, antioxidants cannot penetrate the mitochondrial membrane and, thus, may retain antioxidant, rather than cytotoxic or prooxidant, activities. Low concentrations of retinol and tocopherol exhibit antioxidant and antimutagenic activities, whereas, at high concentration, they are genotoxic [39]. Therefore, both the concentration of the antioxidant and the integrity of the mitochondrial membrane are keys for the antioxidant and cytotoxic activities of the EOs.…”

Section: Study-based Conclusive Talksmentioning

confidence: 99%

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

Islam

Streck²,

Paz³

et al. 2016

Int Arch Med

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The study prepared a nanoemulsion with a diterpenoid isoprenoid alcohol called phytol (PYT) and subsequently tested it for antioxidant capacity. For this, PYT-loaded nanoemulsion was prepared by phase inversion method and both PYT-containing nanoemulsion (PNE) and PYT-free nanoemulsion (PFNE) (2-16 µM) were tested for antiradical activity (DPPH•: 1,1-dipheny-picrylhydrazyl radical; ABTS•+: azino-bisethylbenzthiazoline-sulfonic acid; •OH: hydroxyl radical scavenging; NO•: nitrite oxide radical), lipid peroxidation (LP), reduction potential (RP), and inhibition of hemolysis (HL) in rat erythrocytes in comparison with an α-tocopherol analogue (Trolox -TRO -positive control). In addition, an in vivo test was performed with wildtype and deficient Saccharomyces cerevisiae strains using hydrogen peroxide (H 2 O 2 ) as a stressor. Results suggest that PNE exhibited higher antioxidant than the PFNE. Increasing doses reveled antioxidant capacity in a dose-dependent manner. In the S. cerevisiae study, both PFNEand PNE-treated groups exhibited decreased rates of survival with the highest doses, whichever in the presence of stressor increased the survival rates, which indicates antioxidative defense capacity of PYT. In this occasion, PNE exhibited prominent antioxidative defense in the presence of stressor rather than PFNE. In conclusion, PYT exhibited potential antioxidant activity but at high concentration it was toxic to the yeast cells. The production of PYT-nanoemulsions may be relevant to the pharmaceutical sciences.

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Section: Study-based Conclusive Talksmentioning

confidence: 99%

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

Islam

Streck²,

Paz³

et al. 2016

Int Arch Med

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“…Fan and Lou [16] described that some polyphenols were good antioxidants at low concentration but, at higher concentration, they induced cellular DNA damage. Nevertheless, retinol and tocopherol have antioxidant and antimutagenic activities at low concentration but, at high concentration, they become genotoxic [17]. Thus, the cytotoxic activity has been evaluated with the antioxidant activity of essential oils to better understand its biological activity.…”

Section: Introductionmentioning

confidence: 99%

“…In this paper, we describe the isolation and identification of a new compound from T. riparia essential oil, and corresponding in vitro antioxidant and cytotoxic activities. 16,17,18,19,20), suggested the presence of an abietane skeleton ( Figure 1). The presence of two oxygen-bearing quaternary carbons (δC 87.9 and δC 90.8) in Table 2.…”

Section: Introductionmentioning

confidence: 99%

New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities

et al. 2014

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Tetradenia riparia (Hochstetter) Codd belongs to the Lamiaceae family and it was introduced in Brazil as an exotic ornamental plant. A previous study showed its antimicrobial, acaricidal and analgesic activities. Two compounds were isolated from essential oil of T. riparia leaves and identified as 9β,13β-epoxy-7-abietene (1), a new one, OPEN ACCESSMolecules 2014, 19 515 and 6,7-dehydroroyleanone (2), already reported for another plant. The structure of these compounds was determined by spectroscopic analysis and by comparison with literature data. The cytotoxic activities of the essential oil and compounds 1 and 2 were determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and by tumor cells MDA-MB-435 (human breast carcinoma), HCT-8 (human colon), SF-295 (human nervous system) and HL-60 (human promyelocytic leukemia). The essential oil and compound 1 showed high cytotoxic potential of the cell lines SF-295 (78.06% and 94.80%, respectively), HCT-8 (85.00% and 86.54%, respectively) and MDA-MB-435 (59.48% and 45.43%, respectively). Compound 2 had no cytotoxic activity. The antioxidant activity was determined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH), β-carotene-linoleic acid system and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The inhibitory concentration (IC 50 in µg mL −1 ) for essential oil and compound 2 was, respectively 15.63 and 0.01 for DPPH; 130.1 and 109.6 for β-carotenelinoleic acid and 1524 and 1024 for ABTS. Compound 1 had no antioxidant activity. By fractioning the oil, it was possible to identify two unpublished compounds: 1 with high cytotoxic potential and 2 with high antioxidant potential.

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“…Selenium is closely involved in metabolic pathways of glutathione, being an essential element in the selenoprotein glutathione peroxidase (GPX). Because selenium is a component part of glutathione peroxidase, it is possible that selenium neutralizaties free radicals present in cell following the hydrogen peroxide treatment that induces DNA damage (Bronzetti et al, 2001). …”

Section: Resultsmentioning

confidence: 99%

Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

Uysal

Ağar

2005

Braz. arch. biol. technol.

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Protective effects of vitamins and selenium compounds in yeast

Cited by 68 publications

References 38 publications

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities

Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

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